Aging-Research/Biochemistry Lab.
Home Professor Lab. members Publications Lectures Aging/Anti-aging

Publications

  • International J.


    415. Kim, S.M., Lee, B., An, H.J., Kim, D.H., Park, K.C., Noh, S.G., Chung, K.W., Lee, E.K., Kim, K.M., Kim, D.H., Kim, S.J., Chun, P., Lee, H.J., Moon, H.R., Chung, H.Y.: Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. Oncotarget,(2017, in press).


    414. Chung, K.W., Kim, K.M., Choi, Y.J., An, H.J., Lee, B., Kim, D.H., Lee, E.K., Im, E., Lee, J., Im, D.S., Yu, B.P., Chung, H.Y.: The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis, Autophagy,(2017, in press).


    413. Son, J.C., Jeong, H.O., Park, D., No, S.G., Lee, E.K., Lee, J., Chung, H.Y.: miR-10a and miR-204 as a Potential Prognostic Indicator in Low-Grade Gliomas. Cancer Inform, 16, 1-6(2017).


    412. Hwang, S.Y., Kang, Y.J., Sung, B., Jang, J.Y., Hwang, N.L., Oh, H.J., Ahn, Y.R., Kim, H.J., Shin, J., Yoo, M.A., Kim, C.M., Chung, H.Y., Kim, N.D.: Folic Acid is Necessary for Proliferation and Differentiation of C2C12 Myoblasts. J Cell Physiol,(2017, in press).


    411. Kim, D.H., Kim, S.M., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., An, H.J., Kim, K.M,. Yu, B.P., Chung, H.Y.: Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. J Nutr Biochem, 45,104-114(2017).


    410. Park, C.H., Shin, S.H., Lee, E.K., Kim, D.H., Kim, M.J., Roh, S.S., Yokozawa, T., Chung, H.Y.: Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res, 31(5),721-728 (2017).


    409. Lee, K.P., Park, S.J., Kang, S., Koh, J.M., Sato, K., Chung, H.Y., Okajima, F., Im, D.S.: Omega-3 polyunsaturated fatty acids accelerate airway repair by activating FFA4 in club cells. Am J Physiol Lung Cell Mol Physiol,(2017, in press).


    408. Lee, Y., Heo, G., Lee, K.M., Kim, A.H., Chung, K.W., Im, E., Chung, H.Y., Lee, J.: Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson's disease. Brain Res, 1663,184-193 (2017)


    407. Kim, Y.R., Lee, E.K., Kim, D.H., Kim, K.M., Lee, B., An, H.J., Park, J.W., Moon, K.M., Park, M.H., Chung, K.W., Park, J.Y., Kim, S.J., Yun, H.Y., Son, S., Chun, P., Moon, H.R., Chung, H.Y.: PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol, 92,87-95 (2017).


    406. An, H. J., Lee, B., Kim, D.H., Lee, E.K., Chung, K.W., Park, M.H., Jeong, H.O., Kim, S.M., Moon, K.M., Kim, Y.R., Kim, S.J., Yun, H.Y., Chun, P., Yu, B.P., Moon, H.R., Chung, H.Y.: Physiological characterization of a novel PPAR pan agonist, 2-(4-(5,6-methylenedioxybenzo[d] thiazol-2-yl)-2-methylphenoxy)-2-methylpropanoic acid (MHY2013). Oncotarget, 8(10):16912-16924(2017).


    405 Chung, K.W., Jeong, H.O., Lee, B., Park, D., Kim, D.H., Choi, Y.J., Lee, E.K., Kim, K.M., Park, J.W., Yu, B.P., Chung, H.Y.: Involvement of NF-κBIZ and related cytokines in age-associated renal fibros. Oncotarget, 8(5), 7315-7327(2017).


    404. Kim, D.H., Kim, M.J., Sung, B., Suh, H., Jung, J.H., Chung, H.Y., Kim, N.D. : Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep, 37(1), 281-288 (2017).


    403. Sung, B., Chung, H.Y., Kim, N.D. : Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy. J Cancer Prev, 21(4), 216-226(2016).


    402. Al-Amin, M., Cao, J., Naeem, M., Banna, H., Kim, M.S., Jung, Y., Chung, H.Y., Moon, H.R., Yoo, J.W. : Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation. Drug Des Devel Ther, 10, 3947-3957(2016).


    401. Bae, H.R., Kim, D.H., Park, M.H., Lee, B., Kim, M.J., Lee, E.K., Chung, K.W., Kim, S.M., Im, D.S., Chung, H.Y.: β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation. Oncotarget, 7(41), 66444-66454 (2016)


    400. Park, J.W., Ha, Y.M., Kim, D.H., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., Kim, K.M., Park, Y.J., Kim, D.H., Yun, H.Y., Chun, P., Moon, H.R., Chung, H.Y.: 4-(6,7-Dihydro-5H-indeno[5,6-d] thiazol-2-yl)benzene-1,3-diol prevents UV-induced melanogenesis and wrinkle formation in HRM-2 hairless mice. J Dermatol Sci, 84(2),213-216(2016).


    399. Kim, D.H., Lee, B., Kim, M.J., Park, M.H., An, H.J., Lee, E.K., Chung, K.W., Park, J.W., Yu, B.P., Choi, J.S., Chung, H.Y.: Molecular Mechanism of Betaine on Hepatic Lipid Metabolism: Inhibition of Forkhead Box O1 (FoxO1) Binding to Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). J Agric Food Chem, 64(36), 6819-6825(2016).


    398. Lee, Y., Jo, J., Chung, H.Y., Pothoulakis, C., Im, E. : in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol, 311(4),G655-G666(2016).


    397. Kim, C. H., Lee E. K., Choi Y. J., An H. J., Chung H. O., Park D.E., Ghim B. C., Yu B. P., Back J., Chung H. Y.:Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation. Aging Cell (2016,inpress)


    396. Eom, S.H., Liu, S., Su, M., Noh, T.H., Hong, J., Kim, N.D., Chung, H.Y., Yang, M.H., Jung, J.H. : Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands. Mar Drugs, 14(6). pii: E112(2016)


    395. Jang, E.J., Kim, D.H., Lee, B., Lee, E.K., Chung, K.W., Moon, K.M., Kim, M.J., An, H.J., Jeong, J.W., Kim, Y.R., Yu, B.P., Chung, H.Y.: Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys. Oncotarget, 7(32),50864-50874 (2016).


    394. Choi, Y.J., Moon, K.M., Chung, K.W., Jeong, J.W., Park, D., Kim, D.H., Yu, B.P., Chung, H.Y.: The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging. Oncotarget, 7(33), 52685-52694 (2016).


    393. Jegal, J., Park, S.A., Chung, K., Chung, H.Y., Lee, J., Jeong, E.J., Kim, K.H., Yang, M.H. : Tyrosinase inhibitory flavonoid from Juniperus communis fruits. Biosci Biotechnol Biochem, 80(12):2311-2317 (2016).


    392. Lee, B., Moon, K.M., Kim, S.J., Kim, S.H., Kim, D.H., An, H.J., Jeong, J.W., Kim, Y.R., Son, S., Kim, M.J., Chung, K.W., Lee, E.K., Chun, P., Ha, Y.M., Kim, M.S., Mo, S.H., Moon, H.R., Chung, H.Y.:(Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice. Oxid Med Cell Longev, doi: 10.1155/2016/2761463(2016).


    391. Park, C.H., Lee, J.Y., Kim, M.Y., Shin, S.H., Roh, S.S., Choi, J.S., Chung, H.Y., Song, Y.O., Shin, Y.S., Yokozawa, T.: Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Food Funct, 7(7):3056-63(2016)


    390. Jung, H.A., Ali, M.Y., Jung, H.J., Jeong, H.O., Chung, H.Y., Choi, J.S. : Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. J Ethnopharmacol, 191,152-160 (2016).


    389. Park, D., Kim, B.C., Kim, C.H., Choi, Y.J., Jeong, H.O., Kim, M.E., Lee, J.S., Park, M.H., Chung, K.W., Kim, D.H., Lee, J., Im, D.S., Yoon, S., Lee, S., Yu, B.P., Bhak, J., Chung, H.Y. : RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney. Oncotarget, 7(21),30037-30048 (2016).


    388. Ali, M.Y., Jannat, S., Jung, H.A., Jeong, H.O., Chung, H.Y., Choi, J.S.: Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B, Chem Biol Interact, 252,93-101 (2016)


    387. Na, H.S., Song, Y.R., Kim, S., Heo, J.Y., Chung, H.Y., Chung J.: Aloin Inhibits IL-1β-Stimulated IL-8 Production in KB Cells. J Periodontol, 87(6),e108-115(2016).


    386. Chung, S., Lee, T.J., Reader, B.F., Kim, J.Y., Lee, Y.G., Park, G.Y., Karpurapu, M., Ballinger, M.N., Qian, F., Rusu, L., Chung, H.Y., Unterman, T.G., Croce, C.M., Christman, J.W.: FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget, 7(14),17532-46 (2016).


    385. Park, M.H., Kim, D.H., Kim, M.J., Lee, E.K., An, H.J., Jeong, J.W., Kim, H.R., Kim, S.J., Yu, B.P., Moon, H.R., Chung, H.Y.: Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci,71(3),300-309 (2016).


    384. Jung, H.A., Ali, M.Y., Choi, R.J., Jeong, H.O., Chung, H.Y., Choi, J.S. : Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera. Food Chem Toxicol, 89, 104-111(2016).


    383. Moon, K.M., Jeong, J.W., Lee, B.G., Kim, D.H., Kim, H.R., Woo, Y.W., Lee, E.K., An, H.J., Kim, M.J., Choi, Y.J., Son, S.J., Chun, P.S., Moon, H.R., Chung, H.Y. : Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signaling. Exp Dermatol, 25(8),652-654 (2016).


    382. Bak, J., Je, N.K., Chung, H.Y., Yokozawa, T., Yoon, S., Moon, J.O. : Oligonol Ameliorates CCl 4 -Induced Liver Injury in Rats via the NF-Kappa B and MAPK Signaling Pathways. Oxid Med Cell Longev, 3935841. doi: 10.1155/2016/3935841(2016).


    381. Cheong, K.O., Shin, D.S., Bak, J., Lee, C., Kim, K.W., Je, N.K., Chung, H.Y., Yoon, S., Moon, J.O. : Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. Arch Pharm Res,39(2),279-291(2016).


    380. Lee, B., Kwon, M., Choi, J.S., Jeong, H.O., Chung, H.Y., Kim, H.R. : Kaempferol Isolated from Nelumbo nucifera Inhibits Lipid Accumulation and Increases Fatty Acid Oxidation Signaling in Adipocytes. J Med Food,18(12),1363-1370(2015).


    379. Kim, D.H., Park, M.H., Chung, K.W., Kim, M.J., Park, D., Lee, B., Lee, E.K., Choi, Y.J., Kim, N.D., Yu, B.P., Chung, H,Y.: Suppression of FoxO6 by lipopolysaccharide in aged rat liver. Oncotarget, 6(33),34143-34157(2015).


    378. Jang, E.J., Jeong, H.O., Park, D., Kim, D.H., Choi. Y.H., Chung. K.W., Park. M.H., Yu. B.P.,Chung, H.Y.: Src tyrosine kinase activation by 4-Hydroxynonenal upregulates p38, ERK/AP-1 signaling and COX-2 expression in YPEN-1 cells. Plos one,10(10),e0129244 (2015).


    377. Lim, H.S., Kang, Y.J., Sung, B., Kim, S.H., Kim, M.J., Kim, H.R., Kim, S.J., Choi, Y.H., Moon, H.R., Chung, H.Y., Kim, N.D.: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces cell cycle arrest and apoptosis via the downregulation of Akt in human lung cancer cells. Oncol Rep, 34(5),2431-2138(2015).


    376. Hwang, S.Y., Kang, Y.J., Sung, B., Kim, M., Kim, D.H., Lee, Y., Yoo, M.A., Kim, C.M., Chung H.Y., Kim, N.D.: Folic acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway. Int J Mol Med,36(4),1073-1080(2015).


    375. Jung, Y.R., Lee, E.K., Kim, D.H., Park, C.H., Park, M.H., Jeong, H.O., Yokozawa, T., Tanaka, T., Im, D.S., Kim, N.D., Yu, B.P., Mo, S.H., Chung, H.Y.: Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza. J Nat Prod,78(8),2110-2115(2015).


    374. Lee, K.P., Kang, S., Park, S.J., Kim, J.M., Lee, J.M., Lee, A.Y., Chung H.Y., Choi, Y.W., Lee, Y.G., Im, D.S.: Anti-allergic effect of α-cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments. J Ethnopharmacol,173,361-369(2015).


    373. Sung B., Hwang S.Y., Kim M.J., Kim M., Jeong J.W., Kim C.M., Chung H.Y., Kim N.D.: Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats. Int J Mol Med,36(3),792-800(2015).


    372. Lee, B., Moon, K.M., Son, S., Yun, H.Y., Han, Y.K., Ha, Y. M., Kim, D.H., Chung, K.W., Lee, E. K., Ullah, S., Chun, P., Moon, H. R., Chung H.Y.: (2R/S,4R)-2-(2,4-Dihydroxyphenyl)thiazolidine-4-carboxylic acid prevents UV-induced wrinkle formation through inhibiting ROS and NF-κB signaling. J Dermatol Sci, 79(3),313-316(2015).


    371. Kang, H.K., Lee, B., Son, S., Yun, H.Y., Moon, K.M., Jeong, H.O., Kim, D.H., Lee, E.K., Choi, Y. J., Kim, D.H., Chun, P., Moon, H.R., Chung, H.Y.: (Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one derivatives as novel tyrosinase inhibitors. Biol Pharm Bull, 38(8), 1227-1233 (2015).


    370. Noh, K.K., Chung, K.W., Sung, B., Kim, M.J., Park, C.H., Yoon, C., Choi, J.S., Kim, M.K, Kim, C.M., Kim, N.D., Chung, H.Y. : Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats. Mol Med Rep, 12(3), 3607-3614(2015).


    369. Chung, K.W., Lee, E.K., Kim, D.H., An, H.J., Kim, N.D., Im, D.S., Lee, J.W., Yu, B.P., Chung H.Y.: Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/1L-1 for steatohepatitis. Aging Cell, 14(4), 524-533(2015).


    368. Chung, K.W., Choi, Y.J., Park, M.H., Jang, E. J., Kim, D.H., Park, B.H., Yu, B.P., Chung, H.Y.: Molecular Insights into SIRT1 Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation. J Gerontol A Biol Sci Med Sci, 70(8), 959-968 (2015 ).


    367. Kim, J.M., Lee, K.P., Park, S.J., Kang, S., Huang, J., Lee, J.M., Sato, K., Chung, H.Y., Okajima, F., Im, D.S. : Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4. Acta Pharmacol Sin, 36(7), 813-820(2015).


    366. Kim, S.H., Kang, Y.J., Sung, B., Kim, D.H., Lim, H.S., Kim, H.R., Kim, S.J., Yoon, J.H., Moon, H.R., Chung, H.Y., Kim, N.D. : MHY-449, a novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, mediates oxidative stress-induced apoptosis in AGS human gastric cancer cells. Oncology Reports, 34, 288-294(2015).


    365. Choi, P.R., Kang, Y.J., Sung, B., Kim, J.H., Moon, H.R., Chung, H.Y., Kim, S.E., Park, M.I., Park, S.J., Kim, N.D. : MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells. Int J Oncol, 47, 563-572 (2015).


    364. Yee, S.B., Choi, H.J., Chung, S.W., Park, D.H., Sung, B., Chung, H.Y., Kim, N.D.: Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. Int J Oncol, 47, 747-765 (2015).


    363. Kang, J.S., Han, M.H., Kim, G.Y., Kim, C.M., Chung, H.Y., Hwang, H.J., Kim, B.W., Choi, Y.H.: Schisandrae semen essential oil attenuates oxidative stress-induced cell damage in C2C12 murine skeletal muscle cells through Nrf2?mediated upregulation of HO?1. Int J Mol Med, 35(2), 453-459(2015).


    362. Jeong, J.W., Kim, J.W., Ku, S.K., Kim, S.G., Kim, K.Y., Kim, G.Y., Hwang, H.J., Kim, B.W., Chung, H.Y., Kim, C.M., Choi, Y.H. : Essential oils purified from Schisandrae semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells. BMC Complement Altern Med, 15(7), 1-13 (2015).


    361. Kim, E.L., Wang, H., Park, J.H., Hong, J., Choi, J.S., Im, D.S., Chung, H.Y., Jung, J.H.: Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp. Bioorg Med Chem Lett, 25, 2096-2099(2015).


    360. Jeon, H.J., Kim, Y.S., Park, J.S., Pyo, J.H., Na, H.J., Kim, I.J., Kim, C.M., Chung, H.Y., Kim, N.D., Arking, R., Yoo, M.A.: Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity. Biogerontology, 16(4), 503-516(2015).


    359. Park, M.H., Kim, S.J., Jeong, H.O., Moon, K.M., Son, S., Kim, D.H., Kim, H.R., Kim, M.J., Yun, H.Y., Chun, P., Je, N.K., Yokozawa, T., Moon, H.R., Chung, H.Y.: Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch Pharm Res, 38(4), 505-511(2014).


    358. Kim, B.C., Jeong, H.O., Park, D. Kim, C.H., Lee, E.K., Kim, D.H., Im, E.K., Kim, N.D., Lee, S.H., Yu, B.P., Bhak, J., Chung, H.Y.: Profiling age-related epigenetic markers of stomach adenocarcinoma in young and old subjects. Cancer Informatics, 14,47-54(2015).


    357. Sung, B.K., Chung, H.S., Kim, M.J., Kang, Y.J., Kim, D.H. Hwang, S.Y., Kim, M.J., Kim, C.M., Chung, H.Y., Kim, N.D.: Cytotoxic effects of ethanol extract from Salvia miltiorrhiza BUNGE on human cancer cell lines. Exp Ther Med, 9(4),1421-1428 (2015).


    356. Lee, K.P., Kang, S., Noh, M.S., Park, S.J., Kim, J.M., Chung, H.Y., Je, N.K., Lee, Y.G., Choi, Y.W., Im, D.S. : Therapeutic effects of s-petasin on disease models of asthma and peritonitis, Biomol Ther (Seoul), 23(1), 45-52(2015).


    355. Kim, M., Sung, B., Kang, Y.J., Kim, D.H., Lee, Y., Hwang, S.Y., Yoon, J., Yoo, M., Kim, C.M., Chung, H.Y., Kim, N.D.: The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway. Int J Mol Med, 35(3),755-762(2015).


    354. Jung, K.J., Lee, E.K., Kim, S.J., Song, C.W., Maruyama, N., Ishigami, A., Kim, N.D., Im, D.S., Yu, B.P., Chung, H.Y.: Anti-inflammatory activity of SMP30 modulates NF-κB throughprotein tyrosine Q1 kinase/phosphatase balance. J Mol Med, 93(3),343-356 (2015).


    353. Sung, B., Park, S., Ha, Y.M., Kim, D.H., Park, C.H., Jung, K.J., Kim, M.S., Kim, Y.J., Kim, M.K., Moon, J.O., Yokozawa, T., Kim, N.D., Yu, B.P., Chung, H.Y.: Salicylideneamino-2-thiophenol modulates nuclear factor-κB through redox regulation during the aging process. Geriatr Gerontol Int, 15(2), 211-219 (2015).


    352. Kim, D.H., Park, M.H., Lee, E.K., Choi, Y.J., Chung, K.W., Moon, K.M., Kim, M.J., An, H.J., Park, J.W., Kim, N.D., Yu, B.P., Chung, H.Y.: The roles of FoxOs in modulation of aging by calorie restriction. Biogerontology, 16(1), 1-14(2015).


    351. Park, C.H., Noh, J.S., Fujii, H., Roh, S.S., Song, Y.O., Choi, J.S., Chung, H.Y., Yokozawa, T.: Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice. Drug Discov Ther, 9(1),13-22(2015).


    350. Kim, H.R., Lee, H.J., Choi, Y. J., Park, Y.J., Woo, Y.W., Kim, S.J., Park, M.H., Lee, H.W., Chun, P., Chung, H.Y., Moon, H. R.: Benzylidene-linked thiohydantoin derivatives as inhibitors of tyrosinase and melanogenesis: importance of the β-phenyl-α,β-unsaturated carbonyl functionality. Med Chem Comm, 5(9), 1410-1417(2014).


    349. Park, J.H., Chung, H.Y., Kim, M., Lee, J.H., Jung, M., Ha, H. : Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice. Aginc Cell, 13(4), 709-718(2014).


    348. Kim, D.H., Sung, B., Chung, H.Y., Kim, N.D.: Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine. J Cancer Prev, 19(3),153-160(2014).


    347. Park, M.H., Kim, D.H., Lee, E.K., Kim, N.D., Im, D.S., Lee, J., Yu, B.P., Chung, H.Y.: Age-related inflammation and insulin resistance: a review of their intricate interdependency. Arch Pharm Res, 37(12), 1507-1514(2014).


    346. Xiao, B., Su, M., Kim, E.L., Hong, J., Chung, H.Y., Kim, H.S., Yin, J., Jung, J.H.: Synthesis of PPAR-γ activators inspired by the marine natural product, paecilocin A. Mar Drugs, 12(2),926-939(2014).


    345. Lee, Y., Sung, B., Kang, Y.J., Kim, D.H., Jang, J.Y., Hwang, S.Y., Kim, M., Lim, H.S., Yoon, J.H., Chung, H.Y., Kim, N.D.: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. Int J Oncol, 44(5),1599-1606(2014).


    344. Chiba, T., Tamashiro, Y., Park, D., Kusudo, T., Fujie, R., Komatsu, T., Kim, S.E., Park, S., Hayashi, H., Mori, R., Yamashita, H., Chung, H.Y., Shimokawa, I.: A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Sci Rep, 4,4517(2014).


    343. Jeon, Y.K., Kim, W.J., Shin, M.J., Chung, H.Y., Kim, S.S., Kim, B.H., Kim, S.J., Kim, Y.K., Kim, I.J.: Short-term caloric restriction does not reduce bone mineral density in rats with early type 2 diabetes. Endocrinol Metab (Seoul),29(1),70-76(2014).


    342. Kim, D.H., Sung, B., Kang, Y.J., Jang, J.Y., Hwang, S.Y., Lee, Y., Kim, M., Im, E., Yoon, J.H., Kim, C.M., Chung, H.Y., Kim, N.D.: Anti-inflammatory effects of betaine on AOM/DSS?induced colon tumorigenesis in ICR male mice. Int J Oncol, 45(3),1250-1266(2014).


    341.Kim, D.H., Park, M.H., Chung, K.W., Bae, H.R., Jung, Y.R., Jang, E.J., Park, D., Lee, J.S., Yu, B.P., Chung, H.Y.: The essential role of FoxO6 phosphorylation in aging and calorie restriction. Age, 36(4), 9679 (2014).


    340.Jung, Y.R., Kim, D.H., Kim, S.R., Choi, Y.J., Lee, K.E., Park, J.H., Tanaka, T., Kim, N.D., Yokozawa, T., Park, J.N., Chung, H.Y.: Anti-wrinkle effect of Magnesium lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-κB signaling. Plos One, 9(8), e102689 (2014).


    339.Park, C.H., Kim, D.H., Park, M.H., Kim, M.K., Kim, N.D., Tanaka, T., Yokozawa, T., Chung, H.Y. Moon, H.R.: Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix Improve Age-Related Oxidative Stress and Inflammatory Response Through the PI3K/Akt or MAPK Pathways. American Journal of Chinese Medicine, 42(4),987-1005(2014).


    338.Noh, K.K., Chung, K.W., Choi, Y.J., Park, M.H., Jang, E.J., Park, C.H., Yoon, C.S., Kim, N.D., Chung, H.Y.:β-Hydroxy β-methylbutyrate improves dexamethasone-induced muscle atrophy by modulating the muscle degradation pathway in SD rat. Plos One, 9(7),e102947 (2014).


    337.Choi, Y.J.. Uehara, Y., Park, J.Y., Kim, S.J., Kim, S.R., Lee, H.W., Moon, H.R., Chung, H.Y.:MHY884,a newly synthesized tyrosinase inhibitor,suppresses UVB-induced activation of NF-κB signaling pathway through the down regulation of oxidative stress. Bioorg Med Chem Lett, 24(5), 1344-1348(2014).


    336. Choi, Y.J., Kim, H.S., Lee, J., Chung, J., Lee, J.S., Choi, J.S., Yoon, T.R., Kim, H.K.,Chung, H.Y.: Down-regulation of oxidative stress and COX-2 and iNOS expressions by dimethyl lithospermate in aged rat kidney. Arch Pharm Res, 37(8), 1032-1088(2014).


    335. Sung, B., Kang, Y.J., Kim,D.H., Hwang, S.Y., Lee, Y., Kim, M., Yoon, J.H., Kim, C.M., Chung, H.Y., Kim, N.D.: Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Oncol, 33(4),943-949 (2014).


    334. Park, S.J., Lee, K.P., Kang, S., Lee, J., Sato, K., Chung, H.Y., Okajima, F., Im, D.S. : Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. Cellular Signalling, 26(10), 2249-2258 (2014).


    333. Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P.,: Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System. Pharmacol Rev, 66(3),815-868(2014)


    332. Lee, S.H., Kang, Y.J., Sung, B., Kim, D.H., Lim, H.S., Kim, H.R., Kim, S.J., Yoon, J.H., Moon, H.R., Chung, H.Y., Kim, N.D.: MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells. Int J Oncol. 44(3),905-911(2014).


    331. Lee, S.H., Kang, Y.J., Kim, D.H., Sung, B., Kang, J.A., Chun, P., Yoon, J.H., Moon, H.R., Kim, H.S., Chung, H.Y., Kim, N.D.: A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells. Int J Oncol. 44(3),943-949(2014).


    330. Kim, J.A, Kim, D.H., Hossain, M.A., Kim, M.Y., Sung, B., Yoon, J.H., Suh, H., Jeong, T.C., Chung, H.Y., Kim, N.D.: HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells. Int J Oncol. 44(2),473-480(2014).


    329. Kim, M.K, Kang, Y.J., Kim, D.H., Hossain, M.A., Jang, J.Y., Lee, S.H., Yoon, J.H., Chun, P., Moon, H.R., Kim, H.S., Chung, H.Y., Kim, N.D.: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells. Int J Oncol. 44(1),256-264(2014).


    328. Kim, T.H., Shin, Y.J., Won, A.J., Lee, B.M., Choi, W.S., Jung, J.H., Chung, H.Y., Kim, H.S.: Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin. Biochim Biophys Acta-General subjects 1840(1),615-625 (2014).


    327. Kim, D.H., Park, C.H., Park, D., Choi, Y.J., Park, M.H., Chung, K.W., Kim, S.R., Lee, J.S., Chung, H.Y.: Ginsenoside RC modulated Akt/FoxO1 pathways and suppresses oxidative stess. Arch Pharm Res, 37(6),813-820 (2014).


    326. Kim, D. H., Hossain, M.A., Kang, Y.J., Jang, J.Y., Lee, Y.J., Im, E., Yoon, J.H., Kim, H.S., Chung, H.Y., Kim, N.D.: Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cellls and prevents AOM/DSS-induced colon cancer in mice. Int J Oncol, 43(5),1652-1658(2013).


    325. Park, M.H., Park, J.Y., Lee, H.J., Kim, D.H., Park, D., Jeong, H.O., Park, C.H., Chun, P., Moon, H.R., Chung, H.Y.: Potent Anti-Diabetic Effects of MHY908, a Newly Synthesized PPAR α/γ Dual Agonist in db/db Mice. Plos One, 8(11), e78815(2013).


    324. Park, M.H., Park, J.Y., Lee, H.J., Kim, D.H., Chung, K.W., Park, D., Jeong, H.O., Kim, H.R., Park, C.H., Kim, S.R., Chun, P., Byun, Y., Moon, H.R., Chung, H.Y.: The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity. Plos One, 8(10),e76820(2013).


    323. Kim, D.H., Hossain, M.A., Kim, M.Y., Kim, J.A., Yoon, J.H., Suh, H.S., Choi, Y.H., Chung, H.Y., Kim, N.D.: A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells. Int J Oncol, 43(6), 1915-1924 (2013).


    322. Kim, S.R., Jung, Y.R., An, H.J., Kim, D.H., Jang, E.J., Choi, Y.J., Moon, K.M., Park, M.H., Park, C.H., Chung, K.W., Bae, H.R., Choi, Y.W., Kim, N.D., Chung, H.Y. : Anti-Wrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF-κB Signaling. Plos One, 8(9),e73877 (2013).


    321. Kim, M. E., Kim, H. K., Park, H. Y., Kim, D. H., Chung, H. Y., Lee, J. S.: Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation. J Pharmacol Sci, 121(2), 148-156(2013).


    320. Shin, D. S., Kim, K. W., Chung, H. Y., Yoon, S., Moon, J. O. : Effect of sinapic acid against carbon tetrachloride-induced acute. Arch Pharm Res, 36(5), 626-633(2013).


    319. Park, S. J., Lee, K. P., Kang, S., Chung, H. Y., Bae, Y. S., Okajima, F., Im, D. S.: Lysophosphatidylethanolamine utilizes LPA1 and CD97 in 2 MDA-MB-231 breast cancer cells. Cell Signal, 25(11), 2147-2154(2013).


    318. Chung, K. W., Jeong, H. O., Jang, E. J., Choi, Y. J., Kim, D. H., Kim, S. R., Lee, K. J., Lee, H. J., Chun P., Byun Y., Moon, H. R., Chung, H. Y.: Characterization of a small molecule inhibitor of melanogenesis that inhibits tyrosinase activity and scavenges nitric oxide (NO). Biochim Biophys Acta, 1830(10), 4752-4761(2013).


    317. Jung, K. J., Kim, D. H., Lee, E. K., Song, C. W., Yu, B. P., Chung, H.Y. : Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-κB in aged rat kidney. Free Radic Biol Med, 61, 206-217(2013).


    316. Kim, Y. M., Byun, H. O., Jee, B. A., Cho, H., Seo, Y. H., Kim, Y. S., Park, M. H., Chung, H. Y., Woo H. G., Yoon G.: Implications of time-series gene expression profiles of replicative senescence. Aging Cell, 12,662-634(2013).


    315. Park, J. W., Ha, Y. M., Moon, K. M., Kim, S. R., Jeong, H. O., Park, Y. J., Lee, H. J., Park J. Y., Song, Y. M., Chun P., Byun Y., Moon, H. R., Chung, H. Y.: De novo tyrosinase inhibitor : 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556). Bioorg Med Chem Lett, 23(14), 4172-4176(2013).


    314. Kim, S. H., Ha, Y. M., Moon, K. M., Choi, Y. J., Park, Y. J., Jeong, H. O., Chung, K. W., Lee, H. J., Chun P., Moon, H. R., Chung, H. Y. : Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor. Arch Pharm Res, 36(10), 1189-1197(2013).


    313. Wang, W., Park, D., Ji, S., Yin, S. j., Qian, G. Y., Chung, H. Y., Yang, J. M., Lee, J., Park, Y. D.: Computational prediction for the protein interactions of tyrosinase: Protein experimental interactome MAP. Process Biochemistry, 48(4), 638-648(2013).


    312. Kim, S. R., Jung, Y. R., Kim, D. H., An, H. J., Kim, M. K., Kim, N. D., Chung, H. Y. : Caffeic acid regulates LPS-induced NF-κB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells. Arch Pharm Res, 37(4), 539-547(2014).


    311. Lee, E. K., Jang, E. J., Jung, K. J. , Kim, D. H., Yu, B. P., Chung, H. Y. : Betaine attenuates lysophosphatidylcholine-mediated adhesion molecules in aged rat aorta: modulation of the nuclear factor-κB pathway. Exp Gerontol, 48(5), 517-524(2013).


    310. Kim, S. H., Choi, Y. J., Moon, K. M., Lee, H. J., Woo, Y., Chung, K. W., Jung, Y., Kim, S., Chun P., Byun Y., Ha, Y. M., Moon, H. R., Chung, H. Y.: The inhibitory effect of a synthetic compound, (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione. Bioorg Med Chem Lett, 23(15), 4332-4335(2013).


    309. Kim, D. H.,Park, M.H., Choi, Y.J., Chung, K.W., Park, C.H., Jang, E.J., An, H.J.,Yu, B.P., Chung, H.Y.: Molecualr study of dietary hepatadecane for the anti-inflammatory modulation of NF-kB in the aged kidney. Plos One, 8(3),e59316(2013).


    308. Park, S.J., Seong, B.K.,Jang, E.J., Kim, D.H.,Park, C.H., Choi, Y.J., Ha, Y.M., Kim, M.K., Kim, N.D., Yu, B.P., Chung, H.Y.: Inhibitory Action of Salicylideneamino-z-thiophenol on NF-kB Signaling Cascade and Cyclooxygenase-2. Arch Pharm Res,36(7),880-889(2013).


    307. Park D, Lee, E.K., Jang, E.J., Jeong, H.O., Kim, B.C., Ha, Y.M., Hong, S.E., Yu, B.P., Chung ,H.Y.: Identification of the dichotomous role of age-related LCKin calorie restriction revealed by integrative analysis of cDNA microarray and interactome. AGE, 35(4),1045-1060(2013).


    306. Kim, H.J., Lee, E.K., Park, M.H., Ha, Y.M., Jung, K.J., Kim, M.S., Kim, M.K., Yu, B.P., Chung, H.Y.:Ferulate Protects the Epithelial Barrier byMaintaining Tight Junction Protein Expressionand Preventing Apoptosis in Tert-ButylHydroperoxide-Induced Caco-2 Cells. Phytotherapy Res, 27(3), 362-367(2013).


    305. Kim D. H., Chung J.H., Yoon J. S., Ha Y. M., Bae S., Lee E. K., Jung K. J., Kim M. S., Kim Y. J., Kim M. K., Chung H.Y.: Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressingNF-kB in LPS-stimulated RAW264.7 cells and mouse liver. J Ginseng Res, 37(1), 54-63(2013).


    304. Ha, Y.M., Lee, H.J., Park,D., Jeong, H.O., Park, J.Y., Park, Y.J.,Lee, K.J.,Lee, J.Y.,Moon, H.R.,Chung, H.Y.: Molecular docking studies of (1E,3E,5E)-1, 6-bis(substituted pheny1)hexa-1,3,5triene and 1,4-bis(substituted trans-styry1) benezene analogs as novel tyrosinase inhibitors. Biol Pharm Bull, 36(1), 55-65 (2013).


    303. Bae, S. J., Ha, Y. M., Kim, J.A., Park J.Y., Ha T. K., Park D., Chun, P.S.,Park, N.H., H. R., Moon H.R.,Chung H.Y.: A Novel Synthesized Tyrosinase Inhibitor : (E)-2((2,4-Dihydroxyphenyl)diazenyl)phenyl)phenyl 4-Methylbenzenesulfonate as an Azo-Resveratrol Analong. Biosci Biotechnol Biocheml, 77(1), 65-72(2013).


    302. Chung, K.W., Kim, D.H., Park, M.H., Choi, Y.J., Kim, N.D., Lee, J., Yu, B.P., Chung, H.Y.: Recent advances in calorie restriction research on aging.Exp Gerontol, 48(10),1049-1053(2013).


    301. Bae, S.J., Ha, Y.M., Park, Y.J., Park, J.Y., Song, Y.M., Ha, T.K., Chun, P., Moon, H.R., Chung, H.Y.: Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors. Eur J Med Chem, 57, 383-390(2012).


    300. Li, J.L., Xiao, B., Park, M., Yoo, E.S., Shin, S., Hong, J., Chung, H.Y., Kim, H.S., Jung, J.H..: PPAR-γ Agonistic Metabolites from the Ascidian Herdmania momus. J Nat Prod, 75(12), 2082-2087 (2012).


    299. Ha, Y.M., Uehara, Y., Park, D., Jeong, H.O., Park, J.Y., Park, Y.J., Lee, J.Y., Lee, H.J., Song, Y.M., Moon, H.R., Chung, H.Y.: Synthesis and Preliminary In Vitro Biological Evaluation of 5-Chloro-2-(Substituted Phenyl)Benzo[d]Thiazole Derivatives Designed As Novel Antimelanogenesis Agents. Appl Biochem Biotechnol, 168(6), 1416-1433(2012).


    298. Song, Y.M., Ha, Y.M., Kim, J.A., Chung, K.W., Uehara, Y., Lee, K.J., Chun, P., Byun, Y., Chung, H.Y., Moon, H.R.: Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors. Bioorg Med Chem Left, 22(24),7451-7455(2012).


    297. Hwang, H.J., Hwang, H.J., Kang, Y.J., Hossain, M.A., Kim, D.H., Jang, J.Y., Lee, S.H., Yoon, J.H., Moon, H.R., Kim, H.S., Chung, H.Y., Kim N.D.: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. Int J Oncol, 41(6), 2057-2064(2012).


    296. Li, H.L., Zhou, S.M., Park, D., Jeong, H.O., Chung, H.Y.,Yang, J.M., Meng, F.G., Hu, W.J.: Deceleration of Arginine Kinase Refolding by Induced Hedical Structures. Protein J, 31(4),267-274(2012).


    295. Choi, Y.J., Uehara, Y., Park, J.Y, Chung, K.W., Ha, Y.M., Kim, J.M., Song, Y.M., Chun, P., Park ,J.W., Moon, H.R., Chung, H.Y.: Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide/protein kinase G signaling pathway in murine skin. J Dermatological Sci, 68(3),164-171(2012).


    294. Choi, Y.J., Park, Y.J., Park, J.Y., Jeong, H.O., Kim, D.H., Ha, Y.M., Kim, J.M., Song, Y.M., Heo, H.S., Yu, B.P., Chun, P., Moon, H.R., Chung, H.Y.: Inhibitory Effect of mTOR Activator MHY1485 onAutophagy: Suppression of Lysosomal Fusion. Plos One, 7(8), (2012).


    293.Xiao, B., Yin, J., Park, M., Liu, J., Li, J.L., Kim, E.L., Hong, J., Chung, H.Y., Jung, J.H.: Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists. BioorgMed Chem, 20(16), 4954?4961(2012).


    292. Ahn, M.Y., Kang, D.O., Na, Y.J., Yoon, S., Choi, W.S., Kang, K.W., Chung, H.Y., Jung, J.H., Min,D. S., Kim, H.S.: Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing. Cancer Letters, 325(2),189-199(2012).


    291. Si, Y.X., Wang, Z.J., Park, D., Jeong, H.O., Ye, S., Chung, H.Y., Yang, J.M., Yin, S.J., Qian ,G.Y. : Effects of isorhamnetin on tyrosinase: Inhibition kinetics and computational simulation. Biosci Biotechno Biochem, 76(6), 1091-1097(2012).


    290. Chung, K.W., Park, Y.J., Choi, Y.J., Park, M.H., Ha, Y.M., Uehara, Y., Yoon, J.H., Chun, P., Moon, H.R., Chung, H.Y.: Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor(E)-3-(2,4dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP). Biochimt BiophysActa, 1820(7),962-969 (2012).


    289. Yin, S.J., Lu, Z.R., Park, D., Chung, H.Y., Yang, J.M., Zhou, H.M., Qian, G.Y., Park, Y.D. : Trifluoroethanol-induced changes in activity and conformation of manganese-containing superoxide dismutase. Appl Biochem Biotechnol , 166(2), 276-288 (2012).


    288. Si, Y.X., Wang, Z. J., Park, D., Chung, H. Y., Wang, S. F., Yan, L., Yang, J. M., Qian, G. Y., Yin. S. J., Park. Y. D.: Effect of hesperetin on tyrosinase: Inhibition kinetics intergrated computational simulation study. Int J Biolo Macromol. 50(1), (257-262)(2012).


    287. Hu, W.J., Yan, L., Park, D., Jeong, H.O., Chung, H. Y., Yang, J.M., Ye, Z.M., Qian, GY.: Kinetic, structural and molecular docking studies on the inhibition of tyrosinase induced by arabinose. Int J Biol Macromol, 50(3),694-700(2012).


    286. Son, N., Hur H.J., Sung M.J., Kim M.S., Hwang J.T., Park J.H., Yang H.J., Kwon D.Y., Yoon S.H., Chung H.Y., Kim H.J.: Liquid Chromatography-Mass Spectrometry-based Metabolomic Analysis of Livers from Aged Rats. J Proteome Res,11(4), 2551-2558(2012).


    285. Ha, Y.M., Park Y.J., Kim J.A., Park D., Park J.Y., Lee H.J., Lee J.Y., Moon H.R., Chung H.Y.: Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors. Eur J Med Chem, 49, 245-252 (2012).


    284. Lee, S.H., Park J.S., Kim Y.S., Chung H.Y., Yoo M.A.: Requirement of matrix metalloproteinase-1 for intestinal homeostasis in the adult Drosophila midgut. Exp Cell Res, 670-681 (2012).


    283. Han,Y. K., Park, Y.J., Ha Y. M., Park D., Lee J.Y., Lee N.,Yoon J.H., Moon H.R., Chung H.Y. : Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl) thiazolidine-4-carboxylic acid (MHY384). BBA ? Gen. Subjects, 1820(1), 542-549 (2012).


    282. Hossain, M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in nude mice xenograft model. Int J Oncol, 40(4),1298-1304(2012).


    281. Hossain, M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol, 40(5), 1636-1642 (2012).


    280. Park, J.H., Ahn, M.Y., Kim, T.H., Yoon, S., Kang, K.W., Lee, J., Moon, H.R., Jung, J.H., Chung, H.Y., Kim, H.S.: A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. Invest New Drug, 30(5), 1887-1898(2012).


    279. Lim, H.A., Lee, E.K., Kim, J.M., Park, M.H., Kim, D.H., Choi, Y.J., Ha, Y.M., Yoon, J.H., Choi, J.S., Yu, B.P., Chung, H.Y.: PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney. Biogerontology, 13(2), 133-145(2012) .


    278. Kim, D.H., Kim, J.M., Lee, E.K., Choi, Y.J., Kim, C.H., Choi, J.S., Kim N.D., Yu, B.P., Chung, H.Y.: Modulation of FoxO1 phosphorylation/acetylation by baicalin during aging. J Nutr Biochem, 23(10), 1277-1284(2012) .


    277. Choi, Y.J., Kim, D.H., Lee, E.K., Kim, J.M., Ha, Y.M., Kim, N.D., Jung, J.H., Choi, J.S., Yu, B.P., Chung, H.Y.: Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate. AGE,34, 317-327 (2012) .


    276. Kim, J.M., Heo, H.S., Ha, Y.M., Ye, B.H., Lee, E.K., Choi, Y.J., Yu, B.P., Chung, H.Y.: Mechanism of Ang II involvement in activation of NF-κB through phosphorylation of p65 during aging. AGE, 34(1), 11-25 (2012) .


    275. Kim, H.S., Je J.H., Son T.G., Park H.R., Ji S.T., Pokharel Y.R., Jeon H.M., Kang K.W., Kang H.S., Chang S.C., Kim H.S., Chung, H.Y., Lee J.: The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Free Radical Res. 46(1), 21-29 (2012).


    274. Ha, Y.M., Park, Y.J., Lee, J.Y., Choi, Y.J., Lee, E.K., Kim, J.M., Kim, J.A., Park, J.Y., Lee, H.J., Moon,H.R., Chung, H.Y.: Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. Biochimie, 94, 533-540 (2012) .


    273. Kim, M.S., Park, H.R., Chung, H.Y., Kim, H.S., Yu, B.P., Yang, H.S., Lee, J.: Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem Biol Interact,194, 139-147 (2011).


    272. Yan, L., Yin, S.J., Park, D., Xi, Y., Wang, Z., Chung, H.Y., Yang, J.M., Qian, G., Park, Y.D.: Computational simulations integrating inhibition kinetics of tyrosinase by oxalic acid. Int Res J Pharm Pharmacol, 1(6), 126-135 (2011) .


    271. Li, C., Sun, S., Park, D., Jeong, H.O., Chung, H.Y., Liu, X., Zhou, H.: Hydrogen peroxide targets the cysteine at the active site and irreversibly inactivates creatine kinase. Int J Biol Macromol., 49(5), 910-916 (2011).


    270. Lee, J.E., Heo, J.I., Park, S.H., Kim, J.H., Kho, Y.J., Kang, H.J., Chung, H.Y., Yoon, J.L., Lee, J.Y.: Calorie restriction (CR) reduces age-dependent decline of non-homologous end joining (NHEJ) activity in rat tissues. Exp Gerontol, 46(11), 891-896, (2011).


    269. Kim, J.M., Uehara, Y., Choi, Y.J., Ha, Y.M., Ye, B.H., Yu, B.P., Chung, H.Y.: Mechanism of attenuation of pro-inflammatory Ang II-induced NF-κB activation by genistein in the kidneys of male rats during aging. Biogerontology, 12, 537-550, (2011).


    268. Liu, J., Li, F., Kim, E.L., Li, J.L., Hong, J., Bae, K.S., Chung, H.Y., Kim, H.S., Jung, J.H.: Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii. J Nat Prod, 74(8), 1826-1829, (2011).


    267. Gong, E.J., Park, H.R., Kim, M.E., Piao, S., Lee, E., Jo, D.G., Chung, H.Y., Ha, N.C., Mattson, M.P., Lee, J.: Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiol Dis , 44(2), 223-230, (2011) .


    266. Ha,Y. M., Kim, J.A., Park, Y.J., Park, A., Choi, Y.J., Kim, J.M., Chung, K.W., Han, Y. K., Park, J.Y., Lee, J.Y., Moon,H.R., and Chung, H.Y.: Synthesis and biological activity of hydroxybenzylidenyl pyrrolidine-2,5-dione derivatives as new potent inhibitors of tyrosinase. Med Chem Comm ,2(6), 542-549, (2011) .


    265. Yang,J.L., Yin,S.J., Si,Y.X., L¨u,Z.R., Shao,X., Park,D., Chung, H.Y.,Zhou,H.M., Qian,G.Y., and Zhang, Z.P.: Towards Al3+-InducedManganese-ContainingSuperoxide Dismutase Inactivation and Conformational Changes:An Integrating Study with Docking Simulations. Enzyme Res, 2011, 307464~ , (2011) .


    264. Pack, D., Jeong, H.O.,Kim, B.C., Ha, Y.M., Chung, H.Y.: Computational Approach to Identify Enzymes That Are Potential Therapeutic Candidiates for Psoriasis. Enzyme Res,2011, 826784~ (2011) .


    263. Chung, H.Y., Lee, E.K., Choi, Y.J., Kim, J.M., Kim, D.H., Zou, Y., Kim, C.H., Lee, J, Kim, H.S., Kim, N.D., Jung, J.H., Yu, B.P.: Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases. J Dent Res, 90(7), 830-840 (2011) .


    262. Shi, L., Xia, Y., Zhang, M., Yin, S.J., Si, Y.X., Qian, G.Y., Lu, Z.R., Zhou, H.M., Park, D., Chung, H.Y., Zou, F., Park, Y.D.: Trifluoroethanol-Induced Activity and Structural Changes in Bos Taurus Copper- and Zinc-Containing Superoxide Dismutase. Protein Peptide Lett, 18(7),726-732(2011) .


    261. Ha, Y.M., Park, J.Y., Park, Y.J., Park, D., Choi, Y.J., Kim, J.M., Lee, E.K., Han, Y.K., Kim, J.A., Lee, J.Y., Moon, H.R., Chung, H.Y.: Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells. Bioorg Med Chem Lett, 21(8), 2445-2449 (2011) .


    260. Ha, Y.M., Kim, J.A., Park, Y.J., Park, D., Kim, J.M., Chung, K.W., Lee, E.K., Park, J.Y., Lee, J.Y., Lee, H.J., Yoon, J.H., Moon, H.R.,Chung, H. Y.: Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation. BBA-GEN SUBJECTS, 1810(6), 612-619 (2011).


    259. Si, Y.X., Yin, S.J., Park, D., Chung, H.Y., Yan, L., Lu, Z.R., Zhou, H.M., Yang, J.M., Qian ,G.Y., Park, Y.D.: Tyrosinase inhibition by isophthalic acid: Kinetics and computational simulation. Int J Biol Macromol, 48(4), 700-704 (2011) .


    258. Patra, N., De, U., Kang, J.A., Kim, J.M., Ahn, M.Y., Lee, J., Jung, J.H., Chung, H.Y., Moon, H.R., Kim, H.S.: A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells. Eur J Pharmacol,658(2-3) , 98-107 (2011) .


    257. Kim, J.M., Heo, H.S., Choi, Y.J., Ye, B.H., Seo, A.Y., Yu, B.P., Leeuwenburgh, C., Chung, H.Y., and Carter, C.S.: Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists inaged rat kidney. Exp Gerontol, 6(7), 542-548(2011) .


    256. Carter, C.S., Giovaninni, S., Seo, D.O., Dupree, J., Morgan, D., Chung, H.Y., Lees, H., Daniels, M., Hubbard, G.B., Lee, S., Ikeno, Y., Foster, T.C., Buford, T.W., Marzetti, E.: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age, 33(2), 167-183 (2011) .


    255. Choi. J., Kwon, S.,Park,K.,Yu,B.P.,Kim,N.D.,Jung,J.H., and Chung, H.Y.: The Anti-Inflammatory Action of Fermented Soybean Productsin Kidney of High-Fat-Fed Rats. J Med Food, 14 (3), 232?239 (2011) .


    254. Hayashida, T., Komatsu, T., Henmi, Y., Yanagihara-Ota, K., Kim, A.R., Chiba, T., Goto, S., Chung, H.Y., Shimokawa, I.: Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction. Geriatr Gerontol Int, 11(4), 496-503 (2011).


    253. Dang, H.T., Kang, G.J., Yoo, E.S, Hong, J., Choi, J.S., Kim, H.S., Chung, H.Y., Jung, J.H..: Evaluation of endogenous fatty acid amides and their synthetic analoguesas potential anti-inflammatory leads. Bioorgan Med Chem, 19(4), 1520-1527 (2011) .


    252. Lee, E.K., Kim, J.M., Choi, J., Jung, K.J., Kim, D.H., Chung, S.W., Ha, Y.M., Yu, B.P., Chung, H.Y.: Modulation of NF-κB and FOXOs by baicalein attenuates theradiation-induced inflammatory process in mouse kidney. Free Radical Res, 45(5), 507-517 (2011).


    251. Hong, I.H., Ji, H., Hwa, S.Y., Jeong ,W.Il., Jeong , D.H., Do, S.H., Kim, J.M., Ki, M.R., Park,J.K., Goo, M.J., Hwang, O.K.,Hong, K.S., Youn, H.J., Chung, H.Y., Jeong, K.S.: The Protective Effect of ENA Actimineral ResourceA on CCl4-Induced Liver Injury in Rats. Mar Biotechnol,13, 462-473 (2011).


    250. Kang, S., Park, E.J., JoFe, Y., Seo, E., Park, M.K., Seo, S.Y., Chung, H.Y., Yoo, Y.H., Kim, D.K., Lee, H.J.:Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice. Endocrinology, 151(12), 5638?5646(2010) .


    249. Kim, Y.M.,Shin, H.T,Seo, Y.H.,Byun, H.O.,Yoon, S.H.,Lee, I.K.,Hyun, D.H.,Chung, H.Y.,Yoon, G.:Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence. J Biol Chem,285(38), 29069?29077(2010).


    248. Kwon, J., Lee, B., Chung, H.Y.: Gerontome: a web-based database server for aging-related genes and analysis pipelines. BMC Genomics, 11(suppl 4), S20 (2010).


    247. Park, H.R., Park, M., Choi, J., Park, K.Y.,Chung, H.Y., Lee,J.: A high-fat diet impairs neurogensis: Involvement of lipid peroxidation andbrain-derived neurotrophic factor. Neurosci Lett, 482(3), 235?239 (2010).


    246. Park S-J., Chung, H.Y. and Lee J-H.: Rapid in vivo screening system for anti-oxidant activityusing bacterial redox sensor strains. J Appl Microbiol, 108, 1217-1225 (2010).


    245. Lee,E.K., Jung,K.J., Choi, J., Kim,H.J., Han, Y.K., Jeong,K.S.,Ji,A.R., Park, J.K., Yu, B.P., Chung, H.Y.: Molecular basis for age-related changes in ileum: Involvement ofBax/caspase-dependent mitochondrial apoptotic signaling. Exp Gerontol, 45(12). 970-976 (2010).


    244. Heo,H.S., Lee, S., Kim, J.M., Choi, Y.J.,Chung, H.Y., Oh, S.J.: tsORFdb: Theoretical Small Open Reading Frames (ORFs) database andmassProphet: Peptide Mass Fingerprinting (PMF) tool for unknown small functional ORFs. Biochem Biophys Res Commun, 397(1), 120-126 (2010) .


    243. Choi, J., Bae, S.J., Ha, Y.M., No,J. K., Lee, E.K., Lee, J. S., Song, S., Lee, H., Suh, H., Yu, B.P.,Chung, H.Y.: A newly synthesized, potent tyrosinase inhibitor:5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol. Bioorg Med Chem Lett, 20(16), 4882-4884 (2010) .


    242. Park,J.K., Ki, M.R., Lee, H.R., Hong, I.H., Ji, A.R., Ishigami, A., Park, I.S., Kim, J.M., Chung, H.Y., Yoo, S.E., and Jeong, K.S.:Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology, 51(5), 1766-1777 (2010).


    241. Heo, H.S., Oh,S.J., Kim,H.S., Chung,H.Y.: TREP DB: Transcriptional Regulatory Elements Pattern Database. Biochem Biophys Res Commun,394, 309-316(2010).


    240. Chung, S.W., Kim, J.M., Kim, D.H., Kim, J.Y., Go, E.K.,Anton, S., Jeong, K.S., Lee, J., Yu, B.P., and Chung, H.Y.:Molecular delineation of g-ray-induced NF-kB activation and pro-inflammatory genes in SMP30 Knockout mice. Radiat Res,173(5), 629-634.(2010).


    239. Ahn, M.Y., Chung, H.Y., Choi, W.S., Lee, B.M., Yoon, S and Kim, H.S.: Anti-tumor effect of apicidin on Ishikawa humanendometrial cancer cells both in vitro and in vivoby blocking histone deacetylase 3 and 4. Int J Oncol, 36, 125-131(2010).


    238. Bae, S.J., Lee, J.S.,Kim, J.M., Lee, E.K., Han, Y.K., Kim, H.J., Choi, J., Ha Y.M., No, J.K., Kim, Y.H., Yu, B.P., and Chung, H.Y.: 5-Hydroxytrytophan Inhibits tertButylhydroperoxide(t-BHP)-Induced Oxidative Damage via the Suppressionof Reactive Species (RS) and Nuclear Factor-KB (NF-KB)Activation on Human Fibroblast. J Agr Food Chem, 58(10), 6387-6394 (2010).


    237. Kim, M.K., Chung, S.W., Kim, J.M., Lee, E.K., Kim, D.H., Kim, J.Y., Choi, J.S., Yu, B.P., Kim, Y.J and Chung, H.Y.:Modulation of age-related NF-kB activation by dietary zingerone via MAPK pathway. Exp Gerontol, 45(6), 419-426 (2010).


    236. Bae, S.J., Lee, J.S., Lee, E.K., Kim, J.M., Choi, J.,Heo,H.S., Yu, B.P., and Chung, H.Y.: The anti-apoptotic action of 5-hydroxyindole: Protection of mitochondrial integrity. Biol Pharm Bull, 33(4) 550-555 (2010).


    235. Kim, J.M., Lee, E.K., Patk, G., Kim, M.K., Yokozawa, T., Yu, B.P., and Chung, H.Y.: Morin modulates stress-induced NF-kB pathway through its anti-oxidant activity. Free Radical Res, 44(4), 1-8 (2010).


    234. Kim, J.M., Lee, E.K., Kim,D.H., Yu,B.P., and Chung, H.Y.: Kaempferol modulates pro-


    inflammatory NF-kB activation by suppressing advanced glycation endproducts-induced


    NADPH oxidase. AGE, 32(2), 197-208 (2010).


    233. Ha, Y.M., Chung, S.W., Kim, J.M., Kim, D.H., Kim, J.Y., Lee, E.K., Lee, J., Kim, Y.K., Yoo, M.A., Jeong, K.S., Chung, H.Y.:Molecular activation of NF-κB, pro-inflammatory mediators, and signal pathways in γ-irradiated mice. Biotechnol Lett, 32(2), 373-378(2010).


    232. Hong, S.E., Heo, H.S., Kim, D.H., Kim, M.S., Kim, C.H., Lee, J., Yoo, M.A., Yu, B.P., Leeuwenburgh, C.,Chung, H.Y.: Revealing System-level Correlations between Aging and Calorie Restriction using a Mouse Transcriptome. AGE, 32(1), 15-30 (2010).


    231. Sacket, S.J., Chung, H.Y., Okajima, F.,Im, D.S.: Increase in sphingolipid catabolic enzyme activityduring aging. Acta Pharmacol Sin, 30,1454?1461(2009).


    230. Lee, S.J., Jung, Y.S., Lee, S.H., Chung, H.Y.,Park, B.J.:Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. Int J Oncol, 34(6),1637-1643(2009).


    229. Choi, Y.W., Kim, H.J., Park, S.S., Chung, J. H., Lee, H.W., Oh, S.o., Kim, B.S., Kim, J.B.,Chung, H.Y.., Yu, B.P., Kim, C.D., Yoon,S.: Inhibition of endothelial cell adhesion by the new anti-inflammatoryagent α-iso-cubebene. Vasc. Pharmacol,51(4), 215-224(2009).


    228. Son, T.G., Park, H.R., Kim, S.J., Kim, K., Kim, M.S., Ishigami, A., Handa, S., Maruyama, N., Chung, H.Y., Lee, J.: Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. J Neurosci Res, 87(13), 2890-2897(2009).


    227. Jung, K.J., Lee, E.K., Yu, B.P., Chung, H.Y.: Significance of protein tyrosine kinase/protein tyrosine phosphatase balance on the regulation of NF-κBsinaling in the inflammatory process and aging. Free Radical Biol Med,47(7), 983-991 (2009).


    226. Kim, M.S., Park, H.R., Park, M., Kim, S.J., Kwon, M., Yu, B.P., Chung, H.Y., Kim, H.S., Kwack, S.J., Kang, T.S., Kim, S.H., Lee, J.: Neurotoxic effect of 2,5-hexanedione on neural progenitor cells andhippocampal neurogenesis.Toxicology,260(1-3), 97-103 (2009).


    225. Kim, J.Y., Kim, D.H., Choi, J.K., Park, K.S., Jeong, C.L., Yu, B.P., Chung, H.Y.: Changes in lipid distribution during aging and its modulation by calorie restriction. AGE, 31(2), 127-142(2009).


    224. Lee, E.K., Chung, S.W., Kim, J.Y., Kim, J.M., Heo, H.S., ,Lim H.A., Kim, M.K., Anton, S.,Yokozawa, T., Chung, H.Y.: Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-kappaB Signaling in C57/BL6 Mouse Kidney. J Med Food, 12 (3),542-551(2009).


    223. Zou, Y., Kim, D.H., Jung, K.J., Yu, B. P., and Chung, H.Y.:Lysophosphatidylcholine Enhances Oxidative Stress Via the 5-Lipoxygenase Pathway in Rat Aorta During Aging. Rejuv Res,12(1), 15-24 (2009).


    222. Park, M. J.,Go, E.K., Kim, M.S., Sung, B., Lee, J., Anton, S., Choi, S., Yu, B.P.,and Chung, H.Y.:The Anti-Inflammatory Effect of Kaempferol in Aged Kidney Tissues:The Involvement of Nuclear Factor-κB via Nuclear Factor-InducingKinase/IκB Kinase and Mitogen-Activated Protein Kinase Pathways. J Med Food, 12(2), 351-358(2009).


    221. Chung, S.W., Kim, M.K., Chung, J.H., Kim, D.H., Choi, J.S., Anton, S., Seo, A., Park, K.Y., Yokozawa, T., Rhee, S.H., Yu, B.P., and Chung, H.Y.:Peroxisome Proliferator-Activated Receptor Activation by a Short-term feeding of Zingerone in aged Rats. J Med Food, 12(2), 345-350 (2009).


    220. Jung, K.J., Go, E.K., Kim, J.Y., Yu, B.P., Chung, H.Y.:Suppression of age-related renal changes in NF-κB and its target gene expression by dietary ferulate. J Nutr Biochem, 20(5), 378-388 (2009).


    219. Jung, K.J., Lee, E.K., Kim, J.Y., Zou, Y., Sung, B., Yu, B.P., Chung, H.Y.: Effect of short term calorie restriction on pro-inflammatory NF-κB and AP-1 in aged rat kidney. Inflamm Res, 58(3) 143-150 (2009).


    218. Park, S.E., Park, Cheol, Kim, S.H., Hossain, N. Kim, M.Y., Chung, H.Y., Son, W.S., Kim, K.Y., Choi, Y.H., Kim, N.D.: Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol, 121(2), 304-312 (2009).


    217. Chung, H.Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A.Y., Carter, C., Yu, B.P., Leeuwenburgh, C.: Molecular Inflammation: Underpinnings of Aging and Age-related Diseases. AgeingRes Rev, 8(1), 18-30(2009).


    216. Hyun, S.K., Lee, H., Kang, S.S., Chung, H.Y.andChoi, J. S.: Inhibitory Activities of Cassia tora and Its Anthraquinone Constituents on Angiotensin-Converting Enzyme. Phytother Res, 23(2), 178-184(2009).


    215. Chung, S.W., Ha,Y. M., Kim, Y.J., Song, S., Lee, H., Suh, H., and Chung, H.Y.:Inhibitory effects of 6-(3-Hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis. Arch Pharm Res, 32(2),289-294(2009).


    214. Yoon, N.Y., Kim, H.R., Chung, H.Y., and Choi, J.S.: Anti-hyperlipidemic Effect of an Edible Brown Algae, Ecklonia stolonifera, and its Constituents on Poloxamer 407-Induced Hyperlipidemic and Cholesterol-fed Rats. Arch Pharm Res, 31(12), 1564-1571 (2008).


    213. Son, T.G., Kim, S.J., Kim, K., Kim, M.S., Chung, H.Y., Lee, J.:Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxidative stress. Arch Pharm Res,21(7), 872-877 (2008).


    212. Seo, Y.K., Jung, H.J., Shin, H.T., Kim, Y.M., Yim, H., Chung, H.Y., Lim, I.K.,Yoon, G.: Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell, 7(6), 894-907 (2008).


    211. Chung, J., Lee, H.S., Chung, H.Y., Yoon, T.R., Kim, H.K.: Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages. Biotechnol Lett, 30(9), 1553-1558 (2008).


    210. Marzetti, E., Wohlgemuth, S.E., Lees, H. A., Chung, H. Y., Giovannini, S., Leeuwenburgh, C.: Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mech Ageing Dev, 129(9), 542-549 (2008).


    209. Seo, A. Y., Xu, J., Servais, S., Hofer, T., Marzetti, E., Wohlgemuth, S. E., Knutson, M. D., Chung, H.Y., Leeuwenburgh, C.: Mitochondrial iron accumulation with age and functional consequences. AgingCell, 7(5), 706-716(2008).


    208. Jung, H.A., Jeong, D.M., Chung, H.Y., Lim, H.A., Kim, J.Y., Yoon, N.Y., Choi, J.S.:Re-evaluation of the Antioxidant Prenylated Flavonoids from the Roots of Sophora flavescens. Biol Pharm Bull, 31(5), 908-915 (2008).


    207. Yoon, N.Y., Chung, H.Y., Kim, H.R., Choi, J.S.:Acetyl-and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera. Fisheries Sci, 74, 200-207 (2008).


    206. Kim, S.J., Son, T.G., Park, H.R.,Park, M., Kim, M.S., Kim, H.S., Chung, H.Y., Mattson, M., Lee, J.: Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus. J Biol Chem, 283(21),14497-14505 (2008).


    205. Kim, J.Y., Kim, H.S., Kang, H.S., Choi, J.S., Yokozawa, T., Chung, H.Y.:Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza (red sage) against peroxymitrite. J Med Food, 11(1), 21-28 (2008).


    204. Chung, J.H., Seo, A.Y., Chung, S.W., Leeuwenburgh, C., Yu, B.P., Chung, H.Y.: Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res Rev, 7(2), 126-136 (2008).


    203. Chung, S.W., Toriba, A., Chung,H.Y., Yu, B.P., Kameda, T., Tang, N., Kizu, R., Hayakawa, K.:Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Toxicol Sci,101(1), 152-158 (2008).


    202. Radak, Z., Chung, H.Y., Goto, S.: Systemic adaptation to oxidative challenge induced by regular exercise. Free Radical Biol Med, 44(2), 153-159 (2008)


    201. Kim, D.H., Kim, J.Y., Yu, B.P., Chung, H.Y.: The activation of NF- κB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology, 9(1), 33-47 (2008).


    200. Radak, Z., Chung, H.Y., Koltai, E., Taylor, A.W., Goto, S. : Exercise, oxidative stress and Hormesis. Ageing Res Rev,7(1),34-42 (2008).


    199. Kim, M.S., Kim, M.K., Kim, K.S., Chung, J.H., Kim, S.J., Kim, J.H., Kim, J.R., Lee, J., Yu, B.P., Chung, H.Y.:Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.Toxicol, 243(1-2), 216-223(2008).


    198. Lee, J.S., Jung, I.D., Jeong, Y.I., Lee, C.M., Shin, Y.K., Lee, S.Y., Suh, D.S., Yoon, M.S.,Lee, K.S., Choi, Y.H., Chung, H.Y., Park, Y.M.: D-pinitol inhibits Th1 polarization via thesuppression of dendritic cells. Int Immunopharmacol, 7, 791?804 (2007).


    197. Kim, K.S., Kim, M.S., Seu, Y.B., Chung, H.Y., Kim, J.H., Kim, J.R. : Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells.Aging Cell, 4,535-545 (2007).


    196. Kim, M.K., Kim, K.S., Chung, J.H., Kim, J.H., Kim, J.R., Chung, H.Y., Kim, M.S.:Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells.J. Toxicol Environ Health A, 70(15-16), 1336-1343(2007).


    195. Kim, H.J., Lee, J.S., Chung, H.Y., Song, S.H., Suh, H., Noh, J.S., Song, Y.O.:3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, an active principle of kimchi, inhibits development of atherosclerosis in rabbits. J Agric Food Chem, 55(25), 10486-10492 (2007).


    194. Goto, S., Naito, H., Kaneko, T., Chung, H.Y., Radak, Z.:Hormetic effects of regular exercise in aging: correlation with oxidative stress. Appl Physiol Nutr Metab, 32(5),948-953 (2007).


    193. Kwon, S.H., Ahn, I.S., Kim, S.O., Kong, C.S., Chung, H.Y., Do, M.S., Park, K.Y.:Anti-obesity and hypolipidemic effects of black soybean anthocyanins. J Med Food, 10(3), 552-556(2007).


    192. Ha, Y.M., Chung, S.W., Song, S., Lee, H., Suh, H., Chung, H.Y.:4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: A Potent, New Tyrosinase Inhibitor. Biol Pharm Bull, 30(9), 1711-1715 (2007).


    191. Choi, S.Y., Chung, J.H., Kim, D.H., Chung, S.W., Kim, J.Y., Yu, B.P., Chung, H.Y.:Peroxisome proliferator-activated receptor gamma agonist action of 3-methyl-1,2-cyclopentanedione.Biochim Biophys Acta,1770(12), 1612-1619 (2007).


    190. Go, E.K., Jung, K.J., Kim, M.S., Lim, H., Lim, H.K.,Yu, B.P., Chung, H.Y.: Betaine modulates age-related NF-kB by thionl-enhancing action. Biol Pharm Bull, 30(12), 2244-2249 (2007).


    189.Chung, J.H., Choi, S.Y., Kim, J.Y., Kim, D.H., Lee, J.W., Choi, J.S., Chung, H.Y.: 3-Methyl-1,2-cyclopentanedione Down-Regulates Age-Related NF-kappaB Signaling Cascade. J Agric Food Chem, 55(16), 6787-6792 (2007).


    188. Lee, J.S., Lee , J.C., Lee, C.M., Jung, I.D.,Jeong, Y.I., Seong, E.Y., Chung, H.Y., Park, Y.M.: Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T cells toward a Th1 polarizing phenotype through the activation of dendritic cells. Biochem Pharmacol, 74(1), 86-97(2007).


    187. Kim, Y.J., Chung, H.Y.: Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. J Med Food, 10(2), 225-231(2007).


    186. Kim, D.H., Kim, C.H., Kim, M.S., Kim, J.Y., Jung, K.J., Chung, J.H., An, W.G., Lee, J.W., Yu, B.P., Chung, H.Y.: Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology, 8(5), 545-554 (2007).


    185. Yu, B.P., and Chung, H.Y.:The inflammatory process in aging. Rev. Clin Gerontol, 16(3), 1-9 (2007).


    184. Zou, Y., Kim, CH, Chung, J.H., Kim, J.Y., Chung, S.W., Kim, M.K., Im, D.S., Lee, J., Yu, B.P., Chung, H.Y. :Upregulation of endothelial adhesion molecules by lysophosphatidyl- choline. Involvement of G protein-coupled receptor GPR4. FEBS J, 274(10),2573-2584(2007).


    183. Kim, H.K., Park, H.R., Lee, J.S., Chung, T.S., Chung, H.Y., Chung, J.: Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues. Biogerontology, 8(3), 399-408 (2007).


    182. Lee, J.S., Kim, S.G., Kim, H.K., Lee, T.H., Jeong, Y.I., Lee, C.M., Yoon, M.S., Na, Y.J., Suh, D.S., Park, N.C., Choi, I.H., Kim, G.Y., Choi, Y.H., Chung, H.Y., Park, Y.M.: Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J Cell Physiol, 210(2),385-397 (2007).


    181. Lee, J.S., Lee, C.M., Jeong, Y.I., Jung, I.D., Kim, B.H., Seong, E.Y., Kim, J.I., Choi, I.W., Chung, H.Y., Park, Y.M.: D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett, 581(1), 57-64(2007).


    180. Chung, S.W., Chung, H.Y., Toriba, A., Kameda, T., Tang, N., Kizu, R., Hayakawa, K.: An Environmental Quinoid Polycyclic Aromatic Hydrocarbon, Acenaphthenequinone (AcQ), Modulates COX-2 Expression Through ROS Generation and NF-{kappa}B Activation in A549 Cells. Toxicol Sci, 95(2), 348-355(2007).


    179. Song, S., Lee, H., Jin, Y., Ha, Y.M., Bae, S., Chung, H.Y., Suh, H.: Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett,17(2),461-464(2007).


    178. Lee, J.H., Park, S.E., Hossain, M., Kim, M.Y., Kim, M.N., Chung, H.Y., Choi, J.S., Yoo, Y.H., Kim, N.D.:2,3,6-tribromo-4,5-dihydroxybenzyl Methyl ether Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells. Arch Pharm Res, 30(9), 1132-1137(2007).


    177. Hyun, S.K., Jung, H.A., Chung, H.Y., Choi, J.S.: In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves. Arch Pharm Res, 29(12), 1074-9(2006).


    176. Hyun, S.K., Jung, Y.J., Chung, H.Y., Jung, H.A., and Choi, J.S.: Isorhamnetin Glycosides with Free Radical and ONOO- Scavenging Activities from the Stamens of Nelumbo nucifera. Arch Pharm Res, 29(4), 287-292(2006).


    175. Yoon, Y.S., Yoon, D.S., Lim, I.K., Yoon, S.H., Chung, H.Y., Rojo, M., Malka, F., Jou, M.J., Martinou, J.C., Yoon, G.:Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol, 209(2),468-480(2006).


    174. Yoon, M.S., Lee, J.S., Choi, B.M., Jeong, Y.I., Lee, C.M., Park, J.H., Moon, Y., Sung, S.C., Lee, S.K., Chang, Y.H., Chung, H.Y., Park, Y.M.: Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant. Mol Pharmacol, 70(3), 1033-1044(2006).


    173. Jo, Y., Kim, M., Shin, M.H., Chung, H.Y., Jung, J.H., Im, K.S.: Antioxidative phenolics from the fresh leaves of Ternstroemia japonica. J Nat Prod, 69(10),1399-1403 (2006).


    172. Yu, B.P. and Chung, H.Y.:Adaptive mechanisms to oxidative stress during aging. Mech Ageing Dev, 127(5), 436-443 (2006).


    171. Kim D.H., Kim, H.K., Park, S., Kim, J.Y., Zou, Y., Cho, K.H., Kim, Y.S., Kim, D.H., Yu, B.P., Choi, J.S., Chung, H.Y.: Short-term feeding of baicalin inhibits age-associated NF-κB activation. Mech Ageing Dev, 127(9), 719-725 (2006).


    170. Im, Y.J., Lee, Y.K., Chung, H.Y., Im, D.S.: Multiple actions of lysophosphatidylcholine in human Jurkat T cells. Acta Pharmacol.Sin, 27(6), 700-707 (2006).


    169. Sung, B., Park, S., Yu, B.P., Chung, H.Y.: Amelioration of age-related inflammation and oxidative stress by PPARγ activator: Suppression NF-κB by 2,4-thiazolidinedione. Exp Gerontol, 41(6),590-599(2006).


    168. Choi, H.J., Yee, S.B., Park, S.E., Im, E., Jung, J.H., Chung, H.Y., Choi, Y.H., Kim, N.D.:Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases. Cancer Lett, 232(2), 214-225 (2006).


    167. Seo, A., Hofer, T., Sung, B., Judge, S., Chung, H.Y., Leeuwenburgh, C.: Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid Redox Signal, 8(3-4), 529-538(2006).


    166. Zou, Y., Yoon, S., Jung, K.J., Kim, C. H., Son, T.G., Kim, M.S., Kim, Y.J., Lee, J., Yu, B.P., Chung, H.Y.: Up-regulation of Aortic Adhesion Molecules during Aging. J Gerontol Ser A-Biol Sci Med Sci, 61(3),232-244 (2006) .


    165. Kim, C.H., Zou, Y., Kim, D.H., Kim, N.D.,Yu, B.P., Chung, H.Y.: Proteomic analysis of nitrated and 4-hydroxy-2-nonenal-modified serum proteins during aging. J Gerontol, Ser. A-Biol. Sci. Med. Sci. 61(4),332-338 (2006).


    164. Jung, K.J., Maruyama, N., Ishigami, A., Yu, B.P., Chung, H.Y. : The Redox-sensitive DNA binding sites responsible for the age-related down-regulation of SMP30 by the ERK pathway and its reversal by calorie restriction. Antioxid Redox Signal, 8(3-4), 671-680 (2006).


    163. Kim, Y.J., No, J.K., Lee, J.S., Chung, H.Y.: Antimelanogenic activity of 3,4-dih ydoxyacetophenone: inhibition of Tyrosinase and MITF. Biosci Biotechnol Biochem,70(2), 532-534 (2006).


    162. Jung, K.J., Kim, J.Y., Zou, Y., Yu, B.P., Chung, H.Y.:Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-κB in aged rats. Mech Ageing Dev, 127(3), 223-230(2006).


    161. Chung, H.Y., Sung, B., Jung, K.J., Zou, Y., and Yu, B.P. :The Molecular Inflammatory Process in Aging. Antioxid Redox Signal, 8(3-4), 572-581 (2006).


    160. Kim, H.K., Park, H.R., Sul, K.H., Chung, H.Y., and Chung, J. : Induction of RANTES and CCR5 through NF?κBactivation via MAPK pathway in aged rat gingival tissues. Biotechnol Lett, 28(1),17-23(2006).


    159. No, J.K., Kim, Y.J., Lee, J.S., Chung, H.Y.: Inhibition of Melanogenic activity by 4,4-dihydroxybiphenyl in melanoma cells. Biol Pharm Bull, 29(1),14-16 (2006).


    158. Kim, Y.J.,Kim, H.J., No, J.K., Chung, H.Y., Fernandes, G: Anti-inflammatory action of dietary fish oil and calorie restriction. Life Sci, 78(21), 2523-2532(2006).


    157. Park, D.W., Heo, H.S., Kwon, H.C., and Chung, H.Y.: Protein Function Classification Based on Gene Ontology. Lect. Notes Comput Sci, 691-696(2005).


    156. Shin, S.G., Kim, J.Y., Chung, H.Y., and Jeong, J.C.: Zingerone as an Antioxidant against Peroxynitrite. J Agric Food Chem, 53(19), 7617-7622 (2005).


    155. Go, E.K., Jung. K.J., Kim, J. Y., Yu, B.P.,Chung, H.Y.: Betaine Suppresses Proinflammatory Signaling During Aging: The Involvement of Nuclear Factor-κB via Nuclear Factor-Inducing Kinase/IκB Kinase and Mitogen-activated Protein Kinases. J Gerontol A Biol Sci Med Sci, 60A (10),1252-1264 (2005).


    154. Kim, D. H., Cho, K.H., Moon, S.K., Kim, Y. S., Kim, D.H., Choi, J.S., and Chung, H.Y.: Cytoprotective mechanism of Baicalin against endothelial cell damage by peroxynitrite. J Pharm Phamacol, 57(12),1581-1590 (2005).


    153. Kim, Y.J., Yokozawa, T., Chung, H.Y.: Suppression of oxidative stress in aging NZB/NZW mice: Effect of fish oil feeding on hepatic antioxidant status and guanidine compounds. Free Radic Res, 39(10),1101-1110 (2005).


    152. Hyun, S.K., Kang, S.S., Son, K.H., Chung, H.Y., and Choi, J.S.: Biflavone Glucosides from Ginkgo biloba Yellow Leaves. Chem Pharm Bull, 53(9) 1200-1201(2005).


    151. Radak Z., Chung, H.Y., and Goto S.: Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology, 6(1), 71-75(2005).


    150. Toldy A., Stadler K., Sasvari. M., Jakus J., Jung, K.J., Chung, H.Y., Berkes I., Nyakas C., Radak. Z.: The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain. Brain Res Bull, 65(6), 487-493(2005).


    149. Sung, B., Jung, K.J., Song, H.S., Son, M.J., Yu, B.P., Chung, H.Y.: cDNA representational difference analysis used in the identification of genes related to the aging process in rat kidney. Mech Ageing Dev, 126(8), 882-891(2005).


    148. Kim, A.R., Cho, J.Y., Lee, J.Y., Choi, J.S., Chung, H.Y.: Hydroquinone modulates reactivity of peroxynitrite and nitric oxide production. J Pharm Phamacol, 57(4),475-481 (2005).


    147. Kim, Y.J., Yokozawa T., Chung, H.Y.: Effects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W mice. Br J Nutr, 93(6), 835-844 (2005).


    146. Kim, Y.J., No, J.K., Lee, J.H., Chung, H.Y.: 4,4´-Dihydroxybiphenyl as a New Potent Tyrosinase Inhibitor. Biol Pharm Bull, 28(2), 323-327 (2005).


    145. Kang, M.J., Kim, H.J., Kim, H.K., Lee, J.Y., Kim, D.H., Jung, K.J., Kim, K.W., Baik, H.S., Yoo, M.A., Yu, B.P. Chung, H.Y.: The effect of age and calorie restriction on HIF-1-responsive genes in aged liver. Biogerontology, 6(1), 27-37 (2005).


    144. Son, T. G., Zou, Y., Yu, B.P., Lee, J., Chung, H.Y. : Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction. Free Radic Res, 39(3), 283-289 (2005).


    143. Lee, J.Y., Yu, B.P., Chung, H. Y.: Activation mechanisms of endothelial NF-κB, IKK, and MAP kinase by tert-butyl hydroperoxide. Free Radic Res, 39(4), 399-409 (2005).


    142. Jung, H.A., Chung, H.Y., Kang, S.S., Hyun, S.K., Kang, H.S., and Choi, J.S.: A Phenolic Glucoside Isolated from Prunus serrulata var. spontanea and its Peroxynitrite Scavenging Activity. Arch Pharm Res, 28(10),1127-1130 (2005).


    141. Kim, A.R., Cho, J.Y., Zou,Y., Choi, J.S., and Chung, H.Y.: Flavonoids Differentially Modulate Nitric Oxide production Pathways in Lipopolysaccharide-Activated RAW264.7 Cells. Arch Pharm Res, 28(3), 297-304 (2005).


    140. Jung, H.A., Chung, H.Y., Takako Yokozawa, Kim, Y.C., Hyun, S.K. and Choi, J.S.: Alaternin and Emodin with Hydroxyl Radical Inhibitory and/or Scavenging Activities and Hepatoprotective Activity on Tacrine-Induced Cytotoxicity in HepG2 Cells. Arch Pharm Res, 27(9), 947-953 (2004).


    139. Kang, H.S., Chung, H.Y., Kim, J.Y., Son, B.W., Jung, H.A., and Choi, J.S. : Inhibitory Phlorotannins from the Edible Brown Alga Ecklonia stolonifera on Total Reactive Oxygen Species(ROS) Generation. Arch Pharm Res, 27(2), 194-198 (2004).


    138. Soung, D.Y., Choi, H.R., Kim, J.Y., No, J.K., Lee, J.H., Kim, M.S., Rhee, S.H., Park, J.S., Kim, M.J., Yang, R., Chung, H.Y.: Peroxynitrite Scavenging Activity of Indole derivatives: Interaction of Indoles with Peroxynitrite. J Med Food, 7(1), 84-89 (2004).


    137. Im, J. W., Kim, H. K., Kim, N. D., Choi, J. S., Yu, B,P., Yang, H.S., Chung, H.Y.


    :Activation of cyclooxygenases by H2O2 and t-butylhydroperoxide in aged rat lung. Biotechnol Lett, 26(21),1665-1669 (2004).


    136. Park, T.H., Kim, D.H., Kim, C,H., Jung, H.A., Choi, J.S., Lee J.W., Chung, H.Y. : Peroxynitrite scavenging mode of alaternin isolated from Cassia tora. J Pharm Pharmacol, 56(10), 1315-1321(2004).


    135. Kim, J.Y., Jung K.J., Choi, J.S., Chung, H.Y. : Hesperetin : A Potent Antioxidant Against Peroxynitrite. Free Radical Res, 38(7), 761-769 (2004).


    134. Sung, B., Park, S., Yu, B.P., Chung, H.Y.: Modulation of PPAR in aging, Inflammation, and Calorie Restriction. J Gerontol A Biol Sci Med Sci, 59A(10), 997-1006 (2004).


    133. Lee, J.H., Jung, K.J., Kim, J.W., Kim, H.J., Yu, B.P., Chung, H.Y.: Suppression of apoptosis by calorie restriction in aged kidney. Exp Gerontol, 39(9), 1361-1368 (2004).


    132. Park, S.E., Choi, H.J., Yee, S.B., Chung, H. Y., Suh, H. S., Choi, Y.H., Yoo, Y.H., Kim, N.D. : Synthetic Bile Acid Derivatives Inhibit Cell Proliferation and Induce Apoptosis in HT-29 Human Colon Cancer Cells. Int J Oncol, 25(1), 231-236 (2004).


    131. Je, J.H., Lee, J.Y., Jung, K. J., Sung, B., Go E.K., Yu, B.P., Chung, H.Y. : NF-kB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Lett, 566(1-3), 183-189 (2004).


    130. Jung, J.C., Park, G.T., Kim, K.H., Woo, J.H., An, J.M., Kim, K.C., Chung, H.Y., Bae, Y.S., Park, J.W., Kang, S.S., Lee, Y.S. : Differential Expression of Transforming Growth Factor-b in the Interstitial Tissue of Testis During Aging. J Cell Biochem, 92(1), 92-98 (2004).


    129. Kim, J.W., Zou, Y., Yoon, S., Lee, J.H., Kim, Y.K., Yu, B.P., Chung, H.Y. : Vascular Aging: Molecular Modulation of the Prostanoid Cascade by Calorie Restriction. J Gerontol A Biol Sci Med Sci, 59(9), 876-885 (2004).


    128. Jung, K.J., Ishigami, A., Maruyama, N., Takahashi, R., Goto, S., Yu, B.P., Chung, H.Y.: Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process. Exp Gerontol, 39(8), 1169-1177 (2004).


    127. Lee, J.Y., Je, J.H., Jung, K.J., Yu, B.P., Chung, H.Y. : Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kB activation. Free Radical Biol Med, 37(4), 539-548 (2004).


    126. Radak, Z., Chung, H.Y., Naito, H., Takahashi, R., Jung, K.J., Kim, H.J., and Goto, S. : Age-associated increase in oxidative stress and nuclear factor κB activation are attenuated in rat liver by regular exercise. FASEB J, 18(6), 749-750 (2004).


    125. Kim, C.H., Park, D.U., Chung, A.S., Zou, Y., Jung, K.J., Sung, B.K., Yu, B.P., and Chung, H.Y. : Proteomic analysis of post-mitochondrial fractions of young and old rat kidney. Exp Gerontol, 39(8), 1155-1168 (2004).


    124. Lee, J.Y., Je, J.H., Kim, D.H., Chung, S.W., Zou, Y., Kim, N.D., Yoo,M.A., Baik H.S.,Yu, B.P., Chung, H.Y. : Induction of endothelial apoptosis by 4-hydroxyhexenal. Eur J Biochem, 271(7), 1339-1347 (2004).


    123. Jung, H.A., Chung, H.Y., Jung, J.H., and Choi, J.S. : A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea. Chem Pharm Bull, 52(1), 157-159 (2004).


    122. Kim, A.R., Zou, Y., Park, T.H., Shim, K.H., Kim, M.S., Kim, N.D., Kim, J,D., Bae, S.J., Choi, J.S., and Chung, H.Y. : Active Components from Artemisia iwayomogi Displaying ONOO(-) Scavenging Activity. Phytother Res, 18(1), 1-7 (2004).


    121. Jang, J.H., Aruoma, O.I., Jen, L.S., Chung, H.Y., and Surh, Y.J. : Ergothioneine Rescues PC12 Cells from b-Amyloid-Induced Apoptotic Death. Free Rad Biol Med, 36(3), 288-299 (2004).


    120. No, J.K., Kim, M.S., Kim, Y.J., Bae, S.J., Choi, J.S., and Chung, H.Y. : Inhibition of Tyrosinase by Protocatechuic Aldehyde. Am J Chin Med, 32(1), 97-103 (2004).


    119. Zou, Y., Jung, K.J., Kim, J.W., Yu, B.P., and Chung, H.Y. : Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J, 18(2), 320-322 (2004).


    118. Park, D.U., Kim, C.H., Hong, S.E., Yu, B.P., Chung, H.Y.: A database for oxidative stress and calorie restriction in the study of aging. J Amer Aging Assoc, 26, 11-18 (2003).


    117. Chung, K.O., Kim, B.Y., Lee, M.H., Kim, Y.R., Chung, H.Y., Park, J.H., and Moon, J.O. : In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. J Pharm Pharmacol, 55(12), 1695-1700 (2003).


    116. Soung, D.Y., Rhee, S.H., Kim, J.S., Lee, J.Y., Yang, H.S., Choi, J.S., Yokozawa, T,, Han, Y.N., and Chung, H.Y. : Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza. J Pharm Pharmacol, 55(10), 1427-1432 (2003).


    115. Jung, M.J., Chung, H.Y., Choi, J.H., and Choi, J.S. : Antioxidant Principles from the Needles of Red Pine, Pinus densiflora.Phytother Res, 17(9), 1064-1068 (2003).


    114. Kim, H.Y., Yokozawa, T., Cho, E.J., Cheigh, H.S., Choi, J.S. and Chung, H.Y.: In Vitro and In Vivo Antioxidant Effects of Mustard Leaf (Brassica juncea). Phytother Res, 17(5), 465-471 (2003).


    113. Kang, H.S., Chung, H.Y., Jung, J.H., Son, B.W., Choi, J.S. : A New Phlorotannin from the Brown Alga Ecklonia stolonifera. Chem Pharm Bull, 51(8) 1012-1014 (2003).


    112. Cho, C.G., Kim, H.J., Chung, S.W., Jung, K.J., Shim, K.H., Yu. B.P., Yodoi, J., and Chung, H.Y. : Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process. Exp Gerontol, 38(5), 539-548 (2003).


    111. Chung, H.Y., Yonemochi, E., Saitoh, T., Terada, K., Tozuka, Y., Oguchi, T., Yamamoto, K., Chung, H.Y., and Choi, W.S. : Factors affecting the apparent solubility of ursodeoxycholic acid in the grinding process. Inter J Pharm, 255(1-2), 49-56 (2003).


    110. Kim, J.E., Kim, A.R., Chung, H.Y., Han, S.Y., Kim, B.S. and Choi, J.S. : In Vitro Peroxynitrite Scavenging Activity of Diarylheptanoids from Curcuma longa. Phytother Res, 17(5), 481-484 (2003).


    109. Jung, H.A., Jung, M.J., Kim, J.Y., Chung, H.Y., and Choi, J.S. : Inhibitory Activity of Flavonoids from Prunus davidiana and Other Flavonoids on Total ROS and Hydroxyl Radical Generation. Arch Pharm Res 26(10), 809-815 (2003).


    108. Jung, H.A., Kim, J.E., Chung, H.Y., and Choi, J.S. : Antioxidant Principles of Nelumbo nucifera Stamens. Arch Pharm Res, 26(4), 279-285 (2003).


    107. Yee, S.B., Lee, J.H., Chung, H.Y., Im, K.S., Bae, S.J., Choi, J.S., and Kim, N.D. ; Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. Arch Pharm Res, 26(2), 151-156 (2003).


    106. Jung, M. J., Chung, H. Y., Kang, S. S., Choi, J. H., Bae, K. S., and Choi, J. S. : Antioxidant Activity from the Stem Bark of Albizzia julibrissin. Arch Pharm Res, 26(6), 458-462 (2003).


    105. Kang, H.S., Chung, H.Y., Byun, D.S. and Choi, J.S. : Further Isolation of Antioxidative (+)-1-Hydroxypinoresinol-1-O-β-D-glucoside from the Rhizome of Salvia miltiorrhiza that Acts on Peroxynitrite, Total ROS and 1,1-Diphenyl-2-picrylhydrazyl Radical. Arch Pharm Res, 26(1), 24-27 (2003).


    104. Jung, H.A., Kim, A.R., Chung, H. Y. and Choi, J. S. : In vitro Antioxidant Activity of Some Selected Prunus Species in Korea. Arch Pharm Res, 25(6), 865-872 (2002).


    103. Kim, J.E., Jung, M.J., Jung, H.A., Woo, J.J., Cheigh, H.S., Chung, H.Y. and Choi, J.S. : A New Kaempferol 7-O-Triglucoside from the Leaves of Brassica Juncea L. Arch Pharm Res, 25(5), 621-624 (2002).


    102. Choi, J.S., Jung, M.J., Park, H.J., Chung, H.Y. and Kang S.S. : Further Isolation of Peroxynitrite and 1,1-Diphenyl-2-picrylhy-drazyl Radical Scavenging Isorhamnetin 7-Ο-glucoside from the Leaves of Brassica juncea L. Arch Pharm Res, 25(5), 625-627 (2002).


    101. Son, B.W., Choi, J.S., Kim, J.C., Nam, K.W., Kim, D.S., Chung, H.Y., Kang, J.S. and Choi, H.D.: Parasitenone, a New Epoxycyclohexenone Related to Gabosine from the Marine-Derived Fungus Aspergillus parasiticus. J Nat Prod, 65(5), 794-795 (2002).


    100. Yokozawa, T., Kim, H. Y., Cho, E. J., Choi, J. S. and Chung, H. Y. : Antioxidant Effects of Isorhamnetin 3,7-Di-O-b-D-glucopyranosid Isolated from Mustard Leaf (Brassica juncea) in Rats with Streptozotocin-Induced Diabetes. J Agric Food Chem, 50(19), 5490-5495 (2002).


    99. Chung, H.Y., Kim, H.J., Kim, K.W., Choi, J.S. and Yu, B.P. : Molecular Inflammation Hypothesis of Aging Based on the Anti-Aging Mechanism of Calorie Restriction. Microsc Res Tech, 59(4), 264-272 (2002).


    98. Kim, A.R., Zou, Y., Kim, H.S., Choi, J.S., Chang, G.Y., Kim, Y.J. and Chung, H.Y. : Selective Peroxyntrite Scavenging Activity of 3-methyl-1,2-cyclopentanedione from Coffee Extract. J Pharm Pharmacol, 54(10), 1385-1392 (2002).


    97. Zou, Y., Kim, A.R., Kim, J.E., Choi, J.S. and Chung, H.Y. : Peroxynitrite Scavenging Activity of Sinapic Acid (3,5-Dimethoxy-4-hydroxycinnamic Acid) Isolated from Brassica Juncea. J Agric Food Chem, 50(21), 5884-5890 (2002).


    96. Kim, H.J., Jung, K.J., Arnold Young Seo, Choi, J.S., Yu, B.P. and Chung, H.Y. : Calorie Restriction Modulates Redox-Sensitive Ap-1 during the Aging Process. J Amer Aging Assoc, (AGE), 25, 123-130 (2002).


    95. Kim, H.J., Jung, K.J., Yu, B.P., Cho, C.G., Choi, J.S., and Chung, H.Y. : Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev, 123(12), 1589-1595 (2002).


    94. Kim, H.J., Jung, K.J., Yu, B.P., Cho, C.G.., and Chung, H.Y. : Influence of aging and calorie restriction on MAPKs activity in rat kidney. Exp, Gerontol, 37(8-9), 1041-1053 (2002).


    93. Choi, J.S., Chung, H.Y., Kang, S.S., Jung, M.J., Kim, J.W., No, J.K. and Jung, H.A. : The Structure-Activity Relationship of Flavonoids as Scavengers of Peroxynitrite. Phytother Res, 16(3), 232-235 (2002).


    92. Son, B.W., Choi, J.S., Kim, J.C., Nam, K.W., Kim, D.S. Chung, H.Y., Kang, J.S. and Choi,H.D.: Parasitenone, a New Epoxycyclohexenone Related to Gabosinefrom the Marine-Derived Fungus Aspergillus parasiticus. J Nat Prod,65(5), 794-795 (2002).


    91. Yokozawa, T., Kashiwada, Y., Hattori, M., and Chung, H.Y. : Study on the components of luobuma with peroxynitrite-scavenging activity. Biol Pharm Bull, 25(6), 748-752 (2002).


    90. Han, S.I., Oh, S.Y., Jeon, W.J., Kim J.M., Lee, J.H., Chung, H.Y., Choi, Y.H., Yoo, M.A., Kim, H.D., Kang, H.S. : Mild heat shock induces cyclin D1 synthesis through multiple Ras signal pathways. FEBS lett,515(1-3), 141-145 (2002).


    89. Choi, H.R., Choi, J.S., Han, Y.N., Bae, S.J., and Chung, H.Y. : Peroxynitrite Scavenging Activity of Herb Extracts. Phytother Res, 16(4), 364-367 (2002).


    88. Kim, J.W., No, J.K., Ikeno, Y., Yu, B.P.,Choi, J.S., and Chung, H.Y. : Age-realated changes in redox status of rat serum. Arch Gerontol Geriatr, 34(1), 9-17 (2002).


    87. Kim, H.J., Yu, B.P., and Chung, H.Y. : Molecular exploration of age-related NF-κB/IKK downregulation by calorie restriction in rat kidney. Free Radical Biol Med, 32(10), 991-1005 (2002).


    86. Jung, M.J., Choi, J.H., Chung, H.Y., Jung, J.H. and Choi, J.S. : A new C-methylated flavonoid glycoside from Pinus densiflora. Fitoterapia, 72(8), 943-945 (2001).


    85. Kim, Y.S., Nam, H.J., Chung, H.Y., Kim, N.D., Ryu, J.H., Lee, W.J., Robert A. and Yoo, M .A. : Role of xanthine dehydrogenase and aging on the innate immune response ofDrosophila. J Amer Aging Assoc(AGE),24, 187-194 (2001).


    84. Kwon, H.J., Sung, B.K., Kim, J.W., Lee, J.H., Kim, N.D., Yoo, M.A., Kang, H.S., Baek, H.S., Bae, S.J., Choi, J.S., Ryoya, T., Goto, S., and Chung, H.Y. : The effect of lipopolysaccharide on enhanced inflammatory process with age : modulation of NF-kB. J Amer Aging Assoc(AGE), 24, 163-172 (2001).


    83. Baek, B.S., Kim, J.W., Lee, J.H., Kwon, H.J., Kim, N.D., Kang, H.S., Yoo, M.A., Yu, B.P. and Chung H.Y.: Age-related increase of brain cyclooxygenase activity anddietary modulation of oxidative status. J Gerontol A Biol Sci Med Sci, 56(10),B1-B6 (2001).


    82. Chung, H.Y., Choi, H.R., Park, H.J., Choi, J.S. and Choi, W.C. : Peroxynitrite Scavenging and Cytoprotective Activity of 2,3,6-Tribromo-4,5-dihydroxybenzyl Methyl Ether from the Marine Alga Symphyocladia latiuscula. J Agric Food Chem, 49(8), 3614-3621 (2001).


    81. Yu, B.P.,and Chung, H.Y.: Oxidative stress and vascular aging. Diabetes Res Clin Prac, 54(2), S73-S80 (2001).


    80. Lee. S.M., Ju. S.S., Chung,H.Y., Ha. C.S. and Cho, W.J. : Syntheses and antitumoractivitiesofpolymerscontaining2-acrylamido-2-methyl-1-propanesulfonic acid or 5-fluorouracil. Polymer Bulleti,46, 241-248 (2001).


    79. Kim. J.W., Baek. B.S., Kim. Y.K., Jeremiah T. Herlihy, Yuji Ikeno, Yu. B.P. and Chung, H.Y. : Gene expression of cyclooxygenase in the aging heart. J.Gerontol. : Biological Science, 56A(8), B350-B355 (2001).


    78. Lee, Y.M., Jeong, C.H., Koo, S.Y., Son, M.J., Song, H.S., Bae, S.K., Raleigh, J.A., Chung, H.Y., Yoo, M.A.and Kim, K.W. : Determination of Hypoxia Region by Hypoxic Marker in Developing Mouse Embryos In Vivo : A Possible Signal for Vessel Development. Dev Dyn, 220(2), 175-186 (2001).


    77. Kim, S.H., Han, S.I., Oh, S.Y., Chung, H.Y., Kim, H.D. and Kang, H.S. : Activation of Heat Shock Factor 1 by Pyrrolidine Dithiocarbamate Is Mediated by Its Activities as Pro-oxidant and Thiol Modulator. Biochem Biophys Res Commun, 281(2), 367-372 (2001).


    76. Kim, M.S., Kwon, H.J., Lee, Y.M., Baek, J.H., Jang, J.E., Lee, S.W., Moon, E.J., Kim, H.S., Lee, S.K., Chung, H.Y., Kim, C.W. and Kim, K.W. : Histone Deacetylases induce Angiogenesis by Negative Regulation of Tumor Suppressor Genes. Nature Med, 7(4), 437-443 (2001).


    75. Yu, B.P., and Chung, H.Y. : Stress resistance by caloric restriction for longevity. Ann N Y Acad Sci, 928, 39-47 (2001).


    74. Chung, H.Y., Kim, H.J.,Kim, J.W., and Yu. B.P. : The Inflammation Hypothesis of Aging Molecular Modulation by Calorie Restriction. Ann N Y Acad Sci, 928, 327-335 (2001).


    73. Choi, Y.H., Baek, J.H., Yoo, M.A., Chung, H.Y., Kim, N.D., and Kim, K.W.:Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. Int J Oncol,17(3),565-571(2000).


    72. Choi, J.S., Chung, H.Y., Jung, H.A., Park, H.J. and Yokozawa, T. : Comparative evaluation of antioxidant potential of alaternin (2-hydroxyemodin) and emodin. J Agric Food Chem, 48(12), 6347-6351 (2000).


    71. Chung, H.Y., and Yu, B.P. : Significance of hepatic xanthine oxidase and uric acid in aged and dietary restricted rats. AGE, 23, 123-128 (2000).


    70. Choi, S.H., Kang, H.K., Im, E.O., Kim, Y.J., Bae, Y.T., Choi, Y.H., Lee, K.H., Chung, H.Y., Chang, H.K. and Kim, N.D. : Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids. Int J Oncol, 17(5),971-976 (2000).


    69. Kim, D.K., Baek, J.H., Kang, C.M., Yoo, M.A., Sung, J.W., Kim, D.K., Chung, H.Y., Kim, N.D., Choi, Y.H., Lee, S.H. and Kim, K.W. : Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. Int J Cancer, 87(5), 629-636 (2000).


    68. Choi, J.S., Park, H.J., Jung, H.A., Chung, H.Y., Jung, J.H. and Choi, W.C.: A cyclohexanonyl bromophenol from the red alga symphyocladia latiuscula. J Nat Prod, 63(12), 1705-1706 (2000).


    67. Baek, J.H., Jang, J.E., Kang, C.M., Chung, H.Y., Kim, N.D.and Kim, K.W. : Hypoxia -induced VEGF enhances tumor survivability via suppression of serum deprivation -induced apoptosis. Oncogene, 19, 4621-4631 (2000).


    66. Chung, H.Y., Kim, H.J., Jung, K.J., Yoon, J.S., Yoo, M.A., Kim, K.W. and Yu, B.P. : The inflammatory process in aging. Rev Clin Gerontol, 10, 207-222 (2000).


    65. Yokazawa, T., Sekiya, M., Rhyu, D.Y., Hattori, M., and Chung, H.Y.: Radical-scavenging activity of Wen-Pi-Tang and its component crude drugs: with special reference to the effects on the nitric oxide, superoxide and peroxynitrite. J Trad Med, 17, 41-47 (2000).


    64. Kim, H.J., Kim, K.W., Yu, B.P., and Chung, H.Y. : The effect of age on cyclooxygenase -2 gene expression: NF-κB activation and IκBα degradation. Free Radical Biol Med, 28(5), 683-692 (2000).


    63. Chung, H.Y., Yokozawa, T., Kim, M.S., Lee, K.H., Kim, K.W., Yang, Y., Choi, J.H. : The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cell. Exp Toxic Pathol, 52(3), 227-233 (2000).


    62. Kim, N.M., Kim, J., Chung, H.Y. and Choi, J.S. : Isolation of Luteolin 7-O-rutinoside and Esculetin with Potential Antioxidant Activity from the Aerial parts of Artemisia montana. Arch Pharm Res, 23(2) 237-239 (2000).


    61. Jung, H.A., Park, J.C., Chung, H.Y., Kim, J., and Choi, J.S. : Antioxidant Flavonoids and Chlorogenic Acid from the Leaves of Eriobotrya japonica. Arch Pharm Res, 22(2), 213-218 (1999).


    60. Baek, B.S., Kwon, H.J., Lee. K.H., Yoo, M.A., Kim, K.W., Ikeno, Y., Yu, B.P., and Chung,H.Y. : Regional Difference of ROS Generation, lipid Peroxidation, and Antioxidant Enzyme Activity in Rat Brain and Their Dietary Modulation. Arch Pharm Res, 22(4), 361-366 (1999).


    59. Kang, H.K., Kim, M.S., Kim, N.D., Yoo, M.A., Kim, K.W., Kim, J., Ikeno, Y., Yu, B.P., and Chung, H.Y. : Downregulation of Telomerase in Rat during the Aging Process. Mol Cell, 9(3), 286-291 (1999).


    58. Oh, M.S., Choi, Y.H., Choi, S.H., Chung, H.Y., Kim, K.Y., Kim, S.I., Kim, D.K., and Kim, N.D. : Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int J Oncol, 14, 869-875 (1999).


    57. Chung, H.Y, Kim, H.J., Shim, K.H., and Kim, K.W. : Dietary modulation of prostanoid synthesis in the aging process: role of cyclooxygenase-2. Mech. Ageing Dev, 111, 97-106 (1999).


    56. No, J.K., Soung, D.Y., Kim, Y.J., Shim, K.H., Jun, Y.S., Rhee, S.H., Yokozawa, T., and Chung, H.Y. : Inhibition of tyrosinase by green tea components. Life Sciences, 65(21), PL241-246(1999).


    55. Chung, H.Y., Song, S.H., Kim, H.J., Ikeno, Y., Yu, B.P. : Modulation of Renal Xanthine Oxidoreductase in Aging: Gene Expression and Reactive Oxygen Species Generation. J. Nutr. Health. Aging, 3(1), 19-23 (1999).


    54. Yokozawa, T., Chung, H.Y., Kim, D.W. : Involvement of Superoxide and/or Nitric Oxide in renal Tissue Injury. Exp Toxi Pathol, 51, 517-521 (1999).


    53. Chen, C.P., Yokozawa, T., Chung, H.Y. : Inhibitory effect of caffeic acid analogues isolated from Salviae Miltiorrhizae Radix against 1,1-diphenyl-2-picrylhydrazyl radical. Exp Toxi Pathol, 51, 59-63 (1999).


    52. Soung, D.Y., Chung, H.Y., Yokozawa, T.: A Novel Action of 5-Hydroxytryptamine as a Peroxynitrite Scavenger. Pharm Pharmacol Commun, 4, 583-586 (1998).


    51. Chung, H.Y., Yokozawa, T., Soung, D.Y., Kye, I.S., No, J.K., Baek, B.S. : Peroxynitrite-scavenging Activity of Green Tea Tannin. J Agri Food Chem, 46(11), 4484-4486 (1998).


    50. Lee, Y.N., Lee, H.Y., Lee, Y.M., Chung, H.Y., Kim, S.I., Park, B.C., Lee, S.K., Kim, K.W. : Involvement of glucocorticoid receptor in the induction of differentiation by ginsenosides in F9 teratocarcinoma cells. J Steroid Biochem Mol Biol, 67(2), 105-111 (1998).


    49. Yokozawa, T., Dong, E., Nakagawa, T., Kashiwagi, H., Nakagawa, H., Takeuchi, S., Chung, H.Y. ; In Vitro and in vivo Studies on the Radical-Scavenging Activity of Tea. J Agric Food Chem, 46, 2143-2150 (1998).


    48. Cha, H.J., Park, M.T., Chung, H.Y., Kim, N.D., Hiroshi Sato, Motoharu Seiki, Kim, K.W., : Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene, 16, 771-778 (1998).


    47. Paik, K J., Jeon, S.S., Chung, H.Y., Lee, K.H., Kim, K.W., Chung, J.K., and Kim, N.D. : Induction of Differentiation of the Cultured Rat Mammary Epithelial Cells by Triterpene Acids. Arch Pharm Res, 21(4), 398-405 (1998).


    46. Ki, M.H., Paik, K.J., Lee, J.H., Chung, H.Y., Lee, K.H., Kim, K.W., and Kim, N.D. : All-trans Retinoic Acid Induced Differentiation of Rat Mammary Epithelial Cells Cultured in Serum-free Medium. Arch Pharm Res, 21(3), 298-304 (1998).


    45. Kang, H.S., Chung, H.Y., Jung, J.H., Kang, S.S., and Choi, J.S. : Antioxidant Effect of Salvia miltiorrhiza. Arch Pharm Res, 20(5), 496-500 (1997).


    44. Chung, H.Y., Shim, K.H., Song, S.H., Huh, J.I., Kim, Y.J., Kim, K.W., Im, K.S., Lee, K.H., and Yokozawa, T. : Action Mechanisms of ginseng against oxidative stress and aging. Prog Med, 17, 903-914 (1997).


    43. Yokozawa, T., Dong. E., Chung, H.Y., Oura, H. and Nishioka, I. : A protective action of magnesium lithospermate B on renal function after ischemia-reperfusion of rats and cultured proximal tubular cells. Natural Medicines, 51(4), 287-292 (1997).


    42. Chung, H.Y., Baek, B.S., Song, S.H., Huh, J.I., Shim, K.H., Kim, M.S., Lee, K.H., and Kim, K.W. : Xanthine dehydrogenase/xanthine oxidase and oxidative stress. Age, 20, 127-139 (1997).


    41. Yokozawa. T., Dong, E., Chung, H.Y., Oura, H. and Nakagawa, H. : Inhibitory effect of green tea on injury to a cultured renal epithelial cell line, LLC-PK1. Biosci Biotech Biochem, 61(1), 204-206 (1997).


    40. Kristal, B.S., Jackson, C.T., Chung, H.Y., Matsuda, M., Nguyen, H.D. and Yu, B.P. : Defects at center P underlie diabetes-associated mitochondrial dysfunction. Free Rad. Biol Med, 22(5), 823-833 (1997).


    39. Choi, J.H., Kim, J.I., Kim, D.W., Moon, Y.S., Chung, H.Y., and Yu, B.P. : Analysis of lipid composition and hydroxyl radicals in brain membranes of senescence -accelerated mice. Age, 19, 1-5 (1996).


    38. Chung, H.Y., Yokozawa, T., He, L.Q., and Oura, H. : Effectiveness of green tea tannin on rats with chronic renal failure. Biosci Biotech Biochem, 60 (6), 1000-1005 (1996).


    37. Remmen, H.V., Williams, M.D., Heydari, A.R., Takahashi, R., Chung, H.Y., Yu, B.P. and Richardson, A. : The expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes. J Cell Physiol, 166, 453-460 (1996).


    36. Kim, K.W., Lee, H.Y., Chung, H.Y., Kim, S.I., Lee, S.K., Park, B.C., and Lee, Y.N. : In vitro induction of differentiation by ginsenoside in F9 teratocarcinoma cells. Eur J Cancer, 32A (8), 1420-1428 (1996).


    35. Yokozawa, T., Chung, H.Y., Dong, E. and Oura, H. : Confirmation that magnesium lithospermate B has a hydroxyl radical-scavenging action. Exp Toxic Pathol, 47, 341-344 (1995).


    34. Young, H.S., Lee, C.K., Park, S.W., Park, K.Y., Kim, K.W., Yokozawa, T., Oura, H., and Chung, H.Y. : Antitumor effects of ursolic acid isolated from the leaves of Eribotrya japonica. Natural Medicines, 49(2), 190-192 (1995).


    33. Chung, H.Y., Kim, J.S., Yokozawa, T. and Oura, H. : The promoting action of magnesium lithospermate B on the kinin-prstaglandin E2 system in the kidney. Pharm Toxicol, 76, 240-244 (1995).


    32. Sohn, K.H., Lee, H.Y., Chung H.Y., Young, H.S., Yi, S.Y. and Kim, K.W. : Anti-angiogenic activity of triterpene acids. Can Lett, 94, 213-218 (1995).


    31. Yokozawa, T., Chung, H.Y., Oura, H., Nonaka, G.I. and Nishioka, I. : Antihypertensive effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats. Natural Medicines, 49(2), 164-167 (1995).


    30. Young, H.S., Chung, H.Y., Lee, C.K., Park, K.Y., Yokozawa, T. and Oura, H. : Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system. Biol Pharm Bull, 17(7), 990-992 (1994).


    29. Lee, H.Y., Chung, H.Y., Kim, K.H., Lee, J.J., and Kim, K.W. : Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J Cancer Res Clin Oncol, 120, 513-518 (1994).


    28. Lee, J.H., Lee, S.J., Chung, K.S., Chung H.Y., and Kim, K.W., : Characterization of genomic locus of yeast ASP3 gene. Mol Cells, 4, 510-513 (1994).


    27. Young, H.S., Kim, M.S., Park, J.H., Chung, H.Y., and Choi, J.S., : Phytochemical study on catalpa ovata. Arch Pharm Res, 15(4), 322-327 (1992).


    26. Kim, K.M., Hong, Y.S., Lee, S.J. and Chung, H.Y : Characterization of the asp mutation in asparaginase II-deficient yeast strains. Mol Cells, 2, 139-143 (1992).


    25. Park, H.J., Young, H.S., Park, K.Y., Rhee, S.H., Chung, H.Y. and Choi, J.S. : Flavonoids from the whole plants of Orostachys japonicus. Arch Pharm Res, 14(2), 167-171 (1991).


    24. Yokozawa, T., Chung, H.Y., Lee, T.W., Oura, H., Nonaka, G. and Nishioka, I. : Potentiating effect of converting enzyme inhibitor captopril to the renal responses of magnesium lithospermate B in rats with adenine-induced renal failure. Chem Pharm Bull, 39(3), 732-736 (1991).


    23. Yokozawa, T., Chung, H.Y., Lee, T.W., Oura, H., Nonaka, G. and Nishioka, I. : Magnesium lithospermate B improves renal function via the kallikrein-prostaglandin system in rats with renal failure. Jap J Nephrol, 32(8), 893-898 (1990).


    22. Yokozawa, T., Lee, T.W., Chung, H.Y., Oura, H., Nonaka, G. and Nishioka, I. : Renal responses to Magnesium Lithospermate B. J Pharm Pharmacol, 42, 712-715 (1990).


    21. Yokozawa, T., Lee, T.W., Chung, H.Y., Oura, H., Nonaka, G. and Nishioka, I. : Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal failure. J Nat Prod, 53(3), 662-665 (1990).


    20. Yokozawa, T., Chung, H.Y., Lee, T.W., Oura, H., Tanaka, T., Nonaka, G., and Nishioka, I. : Effect of Magnesium Lithospermate B on urinary excretion of arachidonate metabolites in rats with renal failure. Chem Pharm Bull, 37(10), 2766-2769 (1989).


    19. Yokozawa, T., Chung, H.Y., Oura, H., Nonaka, G., and Nishioka, I. : Isolation of a renal function-facilitating constituent from the Oriental drug, Salviae Miltiorrhizae Radix. Jap J Nephrol, 31(10), 1091-1098 (1989).


    18. Yokozawa, T., Chung, H.Y., Oura, H., Nonaka, G. and Nishioka, I.: Contribution of prostaglandins to the renal responses Magnesium Lithospermate B isolated from Salviae Miltiorrhizae Radix. Chem Pharm Bull, 37(6), 1568-1571 (1989).


    17. Yokozawa, T., Chung, H.Y., Lee, T.W. and Oura, H.: Renal function and urianry prostaglandins in rats given an adenine diet. Jap J Nephrol, 31(6), 671-675 (1989).


    16. Tanaka, T., Morimoto, S., Nonaka, G., Nishioka, I., Yokozawa, T., Chung, H.Y.,and Oura, H.: Magnesium and Ammonium-Potassium Lithospermates B, the active principles having a uremia-preventive effect from Salvia miltiorrhiza. Chem Pharm Bull, 37(2), 340-344 (1989).


    15. Yokozawa, T., Chung, H.Y., Oura, H., Nonaka, G. and Nishioka, I.: Effect of (dihydro) caffeic acid tetramer isolated from Salviae Miltiorrhizae Radix on the renal function. J Med Pharm Soc WAKAN-YUKU, 5(2), 163-166 (1988).


    14. Yokozawa, T., Orihashi, M., Chung, H.Y., Wu, X.Q. and Oura, H.: Effect of "Onpi-to" extract on renal function in rats with renal failure. J Med Pharm Soc WAKAN-YUK, 5(2), 98-103 (1988).


    13. Yokozawa, T., Chung, H.Y., Oura, H., Nonaka, G. and Nishioka, I.: Isolation of active component having uremia-preventive effect from Salviae Miltiorrhizae Radix extract. Chem Pharm Bull, 36(1), 316-320 (1988).


    12. Chung, H.Y., Yokozawa, T. and Oura, H.: Acute effect of extract from Salviae Miltiorrhizae Radix on renal function in renal failure rats. Chem Pharm Bull, 36(1), 274-278 (1988).


    11. Yokozawa, T., Chung, H.Y. and Oura, H.: Urinary constitutes and renal function in rats administered with adenine diet. Jap J Nephrol, 29, 1129-1135 (1987).


    10. Chung, H.Y., Yokozawa, T. and Oura, H.: Renal function-improving effect of SalviaeMiltiorrhizae Radix extract. J Med Pharm Soc WAKAN-YUKU, 4(1), 59-64 (1987).


    9. Chung, H.Y., Yokozawa, T. and Oura, H.: Renal effect of aqueous extract from Salviae Miltiorrhizae Radix in normal rats. Chem Pharm Bull, 35(6), 2465-2469 (1987).


    8. Yokozawa, T., Chung, H.Y. and Oura, H.: Chronic effect of Salviae Miltiorrhizae Radix on renal tissue blood flow and blood pressure in uremic rats. Chem Pharm Bull, 35(3), 1157-1161 (1987).


    7. Yokozawa, T., Zheng, P.D., Chung, H.Y., Fukumoto, J. and Oura, H.: Effect of red Ginseng powder in rats with chronic renal failure. J Med Pharm Soc WAKAN?YUK, 3(2), 136-142 (1986).


    6. Chung, H.Y., Yokozawa, T. and Oura, H.: Effect of extract from Salviae Miltiorrhizae Radix on uremic rats. Chem Pharm Bull, 34(9), 3818-3822 (1986).


    5. Yokozawa, T., Chung, H.Y. and Oura, H.: Effect of extract from Salviae Miltiorrhizae Radix on the urinary urea, creatinine and electrolyte excretion in uremic rats. J Med Pharm Soc WAKAN-YUKU, 3(1), 10-15 (1986).


    4. Yokozawa,T., Chung,H.Y. and Oura,H.: Uremia-improving effect of Salviae Miltiorrhizae Radix in rats. J Med Pharm Soc WAKAN-YAKU, 2(3), 446-451 (1985).


    3. Oura, H., Yokozawa, T. and Chung, H.Y.: Effect of crude drugs on serum constituents in rats with chronic renal failure. J Med Pharm Soc WAKAN-YAKU, 2(3), 434-438 (1985).


    2. Oura, H., Chung, H.Y., Zheng, P.D., Yokozawa,T., Wakaki,K., and Koizumi,F.: Effect of "Onpi-to" administered orally for a long term on rats with chronic renal failure. J Med Pharm Soc, WAKAN-YAKU.2, 365-371 (1985).


    1. Oura, H., Chung, H.Y. and Yokozawa, T.: Effect of each component crude drug of the traditional Chinese prescription "Onpi-to" on rats with chronic renal failure. J Med Pharm Soc WAKAN-YAKU, 2(2), 351-356 (1985).


  • Domestic J.


    85. 허형삼, 김지민, 최은규, 이재원, 김남득, 정해영 : 식이제한에의 한노화조절의 분자기전. Molecular and Cellular Biology News, 21(1), 19-28(2009).


    84. Lee, S. E., Ahn, T. J., Kim, G. S., Kim, Y. O., Han, H. S., Seo, J.S., Chung, H.Y., Park, C. B., Cha, S. W., Park, H. K., and Seong, N, S.: Antioxidant and Anti-fibrotic Properties of Root Extract of Lythrumsalicaria L. in CCL4-Induced Liver Fivrosis Rat Model . Korean J Medicianal Crop Sci, 17(4): 243-250(2009).


    83. Kang, D.Y., Lee, J.Y., Kim, M.S., Kim, C.H., Kim, H.K., Lee, S. M., Kwon, Y.M., Lee, J., Baik, H.S. Yu, B.P., Chung, H.Y.:4-Hydroxynonenal Induces Endothelial Apoptosis through Mitochondrial Depolarization. Kor. J Life Science, 18(11), 1513-1520 (2008).


    82. Song, H., Kim, J.Y., Yoo, M., Chung, H.Y., Kim, J.M., Kim, B.G.: Polyamine Induces Apoptosis Through the Calcium Signaling in Human Prostate Cancer Cells. Kor J Life Science, 16(3), 433-441(2006).


    81. Sung, B., Chung, H.Y.: Significances of Molecular Inflammation and Energy Metabolism during Aging. Journal of Korean Association of Cancer Prevention, 10 (1), 6-17 (2005).


    80. Soung, D.Y., Chung, H.Y., Rhee, S.H., and Park, K.: Age-Related Male Osteoporosis, and Soy, Its alternative Therapy. J. Food Science and Nutrition, 10(3), 298-309(2005).


    79. Ahn, S., Lee J.Y., Chung, H.Y., Yoo, M., Kim J.,Kim, B.G.: Cytoprotective Effects of Polyamines Against Oxidative Stress. Kor J Life Science, 15(4), 626-632 (2005).


    78. Lee, J.Y., No, J.K., Soung, D. Y., Kim, Y.J., Je, J.H., Kim, M.S., Lee, K.H., Chung, H.Y.: ROS/RNS Scavenging Activity of Rosmarinic Acid. Kor. J Gerontol, 15(2), 10-16 (2005).


    77. Kim, T.H., Park, S.Y., Chung, H.Y., Kim, B.G., Yoo, M.A. and Kim, Y.S. : Drosophila p53 Upregulates VDAC Gene Expression That Is Linked to Apoptosis. Kor J Genetics, 27(1), 89-96 (2005).


    76. Kim, Y., Chung, H.Y., Kim, B., and Yoo, M.A. : Effect of age on the Expression of Cell proliferation-Related PCNA and E2F Genes in Drosophila. Kor. J Gerontol, 14(2),18-23 (2004).


    75. Yang, D.J., Kim, Y.S., Park, J.H., Kang, H.S., Baek, H.S., Chung, H.Y., and Yoo, M.A. : STAT is Involved in Defense Response to Oxidative Stress. Kor J Gerontol, 14(1),20-26 (2004).


    74. Chung, H.Y., Sung, B., Jung, K. J., and Kim, C. H. : Molecular Inflammation Hypothesis of Aging. Kor J Gerontol, 14(1), 12-19 (2004).


    73. Yu, B. P., Lim, B. O., and Chung, H. Y. : Oxidative Stress and Calorie Restriction in Aging. Kor J Gerontol, 14(1), 1-11 (2004).


    72. Lee, J.Y., Soung, D.Y., No, J.K., Kim, Y.J., Je, J.H., Kim, M.S., Choi, J.S., Chung, H.Y., and Lee, K.H. : Peroxynitrite (ONOO-) Scavenging Activity of Caffeic Acid. Journal of Korean Association of Cancer Prevention, 8(3), 173-180 (2003).


    71. Kang, H. K., Yee, S.B., Yoo, M.A., Baik, H.S., Chung, H.Y., Kim, N.D.: Effects of Aging and Calorie Restriction on the Extracellular Matrix Proteins in the Rat Tissues. Kor J Gerontol, 13(1), 24-31 (2003).


    70. Chung, H.Y., Park, J.N., Kim, Y.J., Kye, I.S., Lee, J.Y., and Kim, K.W. : Molecular Mechanism of Vascular Development and Aging. Kor. J Gerontol, 12(2), 15-30 (2002).


    69. Kim, S.H., Chu, H.J., Kang, D.H., Song, G.A., Cho, M., Yang, U.S., Kim, H.J., and Chung, H.Y. : NF-κB Binding Activity and Cyclooxygenase-2 Expression in Persistent CCl4-Treated Rat Liver Injury. J Korean Med Sci,17(2), 193-200 (2002).


    68. Chung, H.Y., Lee, J.H., Kim, A.R., Park, T.H., Chung, H.Y., Kim, Y.J., Kwak, S.S., Kim, H.I. and Choi, W.S. : Hepatoprotective Effects of Amorphous and Nano-Particle Preparations of Ursodeoxycholic Acid in CCl4-Induced Mice : Effects of Three Types of Fine Grinding Mills. The Journal of Applied Pharmacology, 10(1), 1-6 (2002).


    67. Kim, J.K., Noh, J.H., Lee, S., Choi, J.S., Suh, H., Chung H.Y., Song, Y.S. and Choi, W.C. The First Total Synthesis of 2,3,6-Tribromo-4,5-dihydroxybenzyl Methyl Ether (TDB) and Its Antioxidant Activity. Bull. Kor Chem Soc, 23(5), 661-662 (2002).


    66. Jung, M.J., Chung, H.Y. and Choi, J.S. : Antioxidant Activity of Roasted Defatted Perilla Seed. Nat Prod Sci, 7(3), 72-75 (2001).


    65. Huh, J.I., Kim, H.J., Kim, J.W., Shim, K.H., Kim, Y.J., Lee, K.H., Yokozawa T., Yu, B.P. and Chung H.Y. : Influence of Aging and Dietary Restriction on Renal Nitric Oxide Synthase. Kor J Gerontol, 11(1), 28-33 (2001).


    64. Yang, Y.H., Kim, Y.J., and Chung, H.Y. : Peroxynitrite and Hydroxyl Radical Scavenging Activity of Dihydroxybenxaldehydes. Kor J Gerontol, 11(3), 24-28 (2001).


    63. Choi, N.H., Kim, Y.S., Hwang, M.S., Nam, H.J., Kim, N.D., Chung, H.Y. and Yoo, M.A. : Expression of Cell Proliferation-Related PCNA and E2F Genes in Drosophila Gut and Inhibitory Effect of Nitric Oxide. Korean J Biol Sci, 5, 59-64 (2001).


    62. Chung, H.Y., Soung, D.Y., Kim, A., Choi, H.R., Kim, H.J., Choi, J.S., Yang, R., Lee, K.H. and Yu, B.P. : Generation, Toxicity and Scavenging of ONOO-: Its Involvement in the Aging Process. Kor J Gerontol, 10(1), 46-59 (2000).


    61. Kwon, H.J., Kang, M.J., Kim, H.J., Choi, J.S., Paik, K.J. and Chung, H.Y. : Inhibition of NF-κB by Methyl Chlorogenate from Eriobotrya japonica. Mol Cells, 10(3), 241-246 (2000).


    60. Chung, H.Y., Choi, H.R., Park, H.J., Choi, J.S. and Choi, W.C. : Peroxynitrite Scavenging Activity of Phloroglucinol from Ecklonia stolonifera. Journal of Korean Association of Cancer Prevention, 5(1), 1-6 (2000).


    59. Choi, J.S., Lee, W.K., Cho, Y.J., Kim, D.S., Kim, A., Chung, H.Y., Jung, J.H., Im, K.S., Choi, W.C., Choi, H.D. and Son, B.W. : Bioactive Carotenoid, Fucoxanthin as Chemotaxonomic Marker and Antioxidative Agent from the Marine Bacillariophycean Microalga Hantzschia marina. Nat Prod Sci, 6(3), 122-125 (2000).


    58. Chung, H.Y., Kim, N.D., Kim, H.J., Kim, J.W., Kim, K.R., Baek, J.H., Yoo, M.A., Woo, J.S., Yu, B.P. and Kim, K.W. : Oxygen-Related Angiogensis and Aging. Kor J Gerontol, 10(3), 1-12 (2000).


    57. Yokozawa, T., Lee, K.I., Kashiwagi, H., Cho, E.J. and Chung, H.Y., : Antioxidant Activity of Herbal Teas Available on the Korean Market. J Food Sci Nutr, 4(2). 92-96 (1999).


    56. Soung, D.Y., Kim, J.S., Chung, H.Y., Jung, H.A., Park, J.C. and Choi, J.S. : Flavonoids and chlorogenic acid from Eriobotrya japonica scavenge peroxynitrite. Nat Prod Sci, 5(2), 80-84 (1999).


    55. Soung, D.Y., Park, J.S., Kim, M.J., No, J.K., Yang, Y.H., Paik, K.J., Yang, R., Choi, J.H., Rhee, S.H. and Chung, H.Y. : Antioxidative Mechanism of Indole Derivatives. Journal of Korean Association of Cancer Prevention, 4(4).196-203 (1999).


    54. Huh, J.I., Baek, B.S., Kim, H.J., Kim, J.W., Im, Y.K., Shim, K.H., Kim, Y.J., Baek, Y.H. and Chung, H.Y. : Up-regulation of Endothelial Renal Nitric Oxide Synthase by Exercise. Kor J Gerontol, 9(2). 45-49 (1999).


    53. Im, Y.K., Yang, Y.W., Kim, J.W., Sohn S.G., Shim, K.H., Kim, Y.J., Chung, H.Y, Choi, W.S., Yamamoto, K., and Chung, H.Y. : Effects of Pefloxacin Grinding on Pharmacokinetic Parameter in Korean Rockfish. Korean J Life Science, 9(3), 241-247 (1999).


    52. Im, Y.K., Kim, J.W., Choi, W.S., Yamamoto K., and Chung, H.Y. : Effect of Grinding on Solubility and Particle Size of Perfloxacin by Planetary Ball-Mill. Korean J Life Science, 9(2), 194-200 (1999).


    51. Park, H.J., Chung, H.Y, Kim, J., and Choi J.S. : Antioxidant Activity of 2,3,6-Tribromo-4,5-dihydroxy benzyl methyl ether from Symphyocladia latiuscula. J Fish Sci Tech, 2(1), 1-7 (1999).


    50. Kye, I.S., Jeon, Y.S., Lee, S.H., No, J.K., Shim, K.H., Kim, Y.J., Beak, B.S., Kim, J., Chung, H.Y., Kim, H.D., and Yu, B.P.: Scavenging Activity of Peroxynitrite and Total Free Radicals of Korean Traditional Teas. Journal of Korean Association of Cancer Prevention, 4(2), 86-92 (1999).


    49. Kye, I.S., Jeon, Y.S., Soung, D.Y., Rhee, S.H., Kim, J., Yokozawa, T., Chung, H.Y., and Lee, K.H.: Cytoprotective Mechanisms of Green Tea Polyphenols in Cultured Liver Cells. Journal of Korean Association of Cancer Prevention, 4(1), 9-16 (1999).


    48. Kye, I.S., Jeon, Y.S., No, J.K., Kim, Y.J., Lee, K.H., Shim, K.H., Kim, J., Yokozawa, T., and Chung, H.Y. : Reactive Oxygen Scavenging Activity of Green Tea Polyphenols. Kor J Gerontol, 9(1), 10-17 (1999).


    47. Kim, Y.J., Chung, H.Y., and Fernandes, G. : Effect of Dietary Restriction on Hepatic Antioxidant Enzyme and Reactive Oxygen Species- Generating Enzyme Activities in the Aging Process of B/W Mice. Kor J Gerontol, 9(1), 23-29(1999).


    46. Park, H.J., Choi, J.S., Chung, H.Y. : The Antioxidant Activity in Extracts of Symphyocladia latiuscula.J Korean fish Soc, 31(6), 927-932 (1998).


    45. Kim, J.W., Shim, K.H., Lee, K.H., Choi, W.C., Lim, W.K., Choi, J.H., Kin, J., and Chung, H.Y.: Effects of Magnesium Lithospermate B from Salvia miltiorrhiza on Hepatic Antioxidant System in Senescence Accelerated mouse (SAM-R/1). Kor J Gerontol, 8(1), 83-89 (1998).


    44. Kang, H.K., No, J.K., Soung, D.Y., Kim, N.D., Lee, K.H., Kim, K.W., Choi, W.C., Lim, U.K., Yu, B.P., and Chung, H.Y. : Effect of aging and dietary restriction on free radical generation and GSH/GSSG level in rat testis. Kor J Gerontol, 7(3), 92-97 (1997).


    43. Baek, Y. H., Kim, S. J., Chung, H. Y. and Choi, J. H. : Effects of Swimming Training on Hepatic Antioxidant Enzymes and Serum Lipid in Cholesterol-Dietary Rats. Korean J. Life Science, 7(4), 384-391 (1997).


    42. Kim, Y. J., No, J. K., Soung, D. Y., Im, Y. K., Baek, B. S., Lee, K. H., Kim, K. W. and Chung, H. Y. : Effects of w3 fatty acids from fish oil on the activities of antioxidant enzymes in cultured kidney cells. Pusan Bull Pharm Sci, 31(2), 67-73 (1997).


    41. Chung, H.Y, Kim, P.S., Shim, K.H., Kim, K.W., Lee, K.H., Kim, J.D. and Kwak, Y.K. : Protective Mechanism of Bismuth Nitrate against the Nephrotoxicity of Mercuric Chloride in Mice. Kor J Gerontol, 7(1), 52-56 (1997).


    40. Kim, J.S., Kim, K.W., Choi, K.J., Kwak, Y.K., Im, K.S., Lee, K.H. and Chung, H.Y. : Screening of Antioxidative Components from Red Ginseng Saponin. Korean J Ginseng Sci, 20(2), 173-178 (1996).


    39. Baek, J.H., Kang, C.M., Chung, H.Y., Park, M.H. and Kim, K.W. : Increased Expression of c-jun in the Bile Acid-Induced Apoptosis in Mouse F9 Teratocarcinoma Stem Cells. J Biochem Mol Biol, 29(1), 68-72 (1996).


    38. Kim, J.S., Huh, J.I., Song, S.H., Shim, K.H., Baek, B.S., Kim, K.W., Lee, K.Y, and Chung, H.Y. : The antioxidative mechanism of ursolic acid. Kor J Gerontol, 6(2), 52-56 (1996).


    37. Kim, J.S., Nam, K., Shim, K.H. Kim, K.W., Im, K.S. and Chung, H.Y. : Antioxidative Mechanism of Total Saponin of Red Ginseng. Korean J Life Science, 6(1), 48-55 (1996).


    36. Kim, J.S., Song, S.H., Kim, K.W., Lee, K.H., and Chung, H.Y. : The antioxidative mechanism of bismuth nitrate. Kor J Gerontol, 5(2), 101-110 (1995).


    35. Kim, A.R. and Chung, H.Y. : Role of glutathione against cytotoxicity of t-butyl hydroperoxide in cultured liver cells. Kor J Gerontol, 5(2), 53-58 (1995).


    34. Moon, S.H., Park, K.Y., Chung, H.Y., and Young , H.S. : Antimutagenic Effects of Traditional Herbal Drugs on the Aflatoxin B1. J Fd Hyd Safety, 10(4), 219-224 (1995).


    33. Im, K.S., Chung, H.Y., Park, S.H. and Je, N.K. : Anticancer Effect of the Hydrolyzed Monogluco-Ginsenoside of Total Saponin from Ginseng leaf. Kor. J Ginseng Sci, 19(3), 291-294 (1995).


    32. Lee, O.H., Kim, J.S., Shim, K.H., Kim, K.W. and Chung, H.Y. : Effect of human milk on the angiogenesis and endothelial cell growth. Korean J Life Science, 5(3), 117-120 (1995).


    31. Kim, J.S., Shim, K.H., Kim, M.S., Kim, K.W., Lee, K.Y. and Chung, H.Y. : Study on the antioxidative activity of human milk. J Korean Soc Food Nutr, 24(5), 651-657 (1995).


    30. Choi, B.T., Choi, Y.H., Chung, H.Y., Lee, W.H. and Jo, U.B. : Lectin histochemistry of glycoconjugates in the testis of SAM (senescence accelerated mice). Korean J Lab Ani Sci, 11(1), 59-66 (1995).


    29. Lee, S.M., Rhee, S.H., Park, K.Y., Rhew, T.H., Kim, B.K. and Chung H.Y. : Antimutagenic effect of insoluble dietary fibers from some green tellow vegetables and soybean by binding the carcinogens. Korean J Life Science, 5(1), 26-32 (1995).


    28. Choi, Y.H., Chung, H.Y., Yoo, M.A. and Lee, W.H., : Effects of ginseng and salvia miltiorrhiza extracts on the mutagenicity of MNNG in Drosophila. Yakhak Hoeji, 38(3), 332-337 (1994).


    27. Choi, Y.H., Choi, B.T., Chung, H.Y., Jo, U.B. and Lee, W.H., : Study on age-related meiotic chromosomal and histological changes in the testis of senescence accelerated mice. Kor J Gerontol, 4(1), 46-50 (1994).


    26. Chung, H.Y., Kim, J.S., and Baek, B.S., : Studies on the mechanism that magnesium lithospermate B improves renal function via prostaglandin and kallikrein-kinin system in rats with renal failure. Kor J Nephrol, 13(1), 35-41 (1994).


    25. Sohn, K.H., Lee, O.H., Lee, Y.N., Chung, H.Y., Lee, J.J., and Kim, K.W.,: Anti-angiogenic activity of ursolic acid. Yakhak Hoeji, 37(5), 532-537 (1993).


    24. Lee, K.I., Rhee, S.H., Kim, J.O., Chung, H.Y., and Park, K.Y., : Antimutagenic and antioxidative effects of Perilla leaf extracts. J Kor Soc Food Nutr, 22(2), 175-180 (1993).


    23. Kim, M.S., Bae, J.M., Park, H.J., Chung, H.Y., Young, H.S., Choi, J.S., and Park, K.Y., : Separation of antimutagenic substance from stembark of catalpa ovata. Environ. Mutagens and Carcinogens, 12, 147-155 (1992).


    22. Chung, H.Y., and Kim, Y.K., : Age-associated alteration in the hepatic superoxide generation and antioxidant activities in the senescence-accelerated mice. Yakhak Hoeji, 36(5), 460-468 (1992).


    21. Rhew, T.H., Park, S.M., Park, K.Y., Chung, H.Y., Hah, J.C. and Lee, C.K., : Effect of ursolic acid on oncogene expression detected by in situ hybridization in Mice. Yakhak Hoeji, 36, 529-537 (1992).


    20. Kim, J.S., Chung, H.Y., Rho, Y.J. and Lee, S.R.: Protective Mechanism of Bismuth Nitrate Against Gentamicin Nephrotoxicity. Yakhak Hoeji, 36(6), 570-576 (1992).


    19. Young, H.S., Kim, M.S., Chung, H.Y., Choi, J.S. and Kim, B.W. : Separation of active chemical components against sarcoma 180 from stembark of catalpa ovata. J Kor Can Assoc, 24(6), 807-812 (1992).


    18. Hah, J.C., Rhew, T.H., Choe, E.S., Chung, H.Y. and Park, K.Y. : Antitumor effect of ursolic acid against inbred hepatoma in CBA/J mouse. J Kor Can Assoc, 24, 790-794 (1992).


    17. Chung, H.Y., Kim, J.S., Rho, Y.J. and Kim, J.D. : Studies on the protective effect of metallothionein induction against nephrotoxicity of aminoglycoside antibiotic. Kor J Nephrol, 11(1), 40-48 (1992).


    16. Chung, H.Y: Aging and Carcinogenic Mechanisms Induced by Free Radicals. Kor J Gerontol, 2(1), 1-11 (1992).


    15. Bae, J.M., Kim, M.S., Park, H.J., Chung, H.Y, Yaung, H.S., Park, K.Y., Moon, S.H. and Choi, J.S. : Antimutagenic principle of artemisia iwayomogi kit. and its action mechanism. J Kor Can Assoc, 24(3), 352-358 (1992).


    14. Choi, Y.A., Rhew, T.H., Park, K.Y., Chung, H.Y., and Hah, J.C. : Effect of ursolic acid isolated from eriobotrya japonica on c-myc and c-Ha-ras oncogene expression at sarcoma 180 cell. J Kor Soc Food Nutr, 21, 314-318 (1992).


    13. Kim, M.S., Bae, J.M., Park, H.J., Chung, H.Y., Young, H.S., Choi, J.S. and Park, G.Y. : Antimutagenic substance from catalpa ovata. Env Muta Car, 12(2), 147-155 (1992).


    12. Oh, M.H., Chung, H.Y., Young, H.S., Kim, K.W., Oura, H. and Yokozawa, T. : Effects of ginsenoside Rb2 on the antioxidants in SAM-R/1 mice. Kor Biochem J, 25(5), 492-497 (1992).


    11. Chung, H.Y., Kim, J.D., Kim, J.S., Kim, D.S., Young, H.S., Rho, Y.J. and Suh,S.S. : Protective effects of bismuth nitrate against the nephrotoxicity of mercuric chloride and gentamicin. Kor J Neph. 10(1), 49-54 (1991).


    10. Chung, H.Y : Aging, active oxygen and atheroscherosis. Korean Life Science, 1, 2-14 (1991).


    9. Chung, H.Y : Active oxygen, cancer and aging. Kor Med Rev, 2, 25-53 (1991).


    8. Park, H.J., Moon, S.H., Park, K.Y., Choi, J.S., Chung, H.Y., Young, H.S. and Suh, S.S. : Antimutagenic effect of Orostachys japonicus. Yakhak Hoeji, 35(4), 253-257 (1991).


    7. Park, K.Y., Kim, S.H., Suh, M.J. and Chung, H.Y : Inhibitory effects of garlic on the mutagenicity in Salmonella assay system and on the growth of HT-29 human colon carcinoma cells. Kor. J. Food Sci Technol, 23(3), 370-374 (1991).


    6. Lee, C.K., Park, S.W., Chung, H.Y., Young, H.S., Suh, S.S., Park. K.Y. : Mechanism of antitumor effect of ursolic acid from Eribotrya japonica. J Kor Cancer Assoc, 23(2), 11-15 (1991).


    5. Kim, S.H., Kim, J.O., Lee, S.H., Park, K.Y., Park, J.P., Chung, H.Y. : Antimutagenic


    compounds identified from the chloroform fraction of Garlic (Allium sativum). J Kor Soc Food Nutr, 20(3), 253-259 (1991).


    4. Choi, J.S., Chung, H.Y., Young,H.S.: A preliminary study on hypocholesterolemic and hypoglycemic activities of some medicinal plants. Kor J Pharm, 21(2), 153-158 (1990).


    3. Chung,H.Y.: Arachidonic acid cascade and intercellular signal transduction. Biochemistry News, 9, 178-187 (1989).


    2. Lee,C.H., Choi,W.S. and Chung,H.Y.: Effect of surfactant as an additive of tablet. Pusan Bull Pharm Sci, 17, 35-40 (1983).


    1. Chough, Y.S. and Chung, H.Y.: Effect of ascorbic acid on the pharmacokinetics of phenobarbital. Seoul Uni. J Pharm Sci, 6, 18-22 (1981).


  • 학회발표


    1. Nam, S.Y., Kwon, J. I., Kim, M.S., Yoo, D.H., and Chung, H.Y.: Dexamethasone lncreases lonizing Radiation lnduced Cell Death through lnduction lkB?. 대한약학회 (1999)


    2. Kwon, H.J., Yoon, J. S., Kim, A.R., Choi, J.S., and Chung, H.Y.: lnhibition of NK ?B by Methylchlorogenate from Eriobotrya japonica. 대한약학회(1999)


    3. No, J. K., Choi H. R., Yoon, J. S., Lee, K. H., Kim, K.W., Yu, B. P., and Chung, H. Y.: Activation of Hepatic Glutathione Peroxydase by lschemical Reperfusion. 대한약학회(1999)


    4. Kim, K.J., No, J. K., Yu, B.P., and Chung, H.Y.: Up-regulation of NK-?B and AP-1 CC14 treated Rat Liver. 대한약학회(1999)


    5. Kim, J. W., Kim, K.W., Yoo, M.A., Lee, K.H., Kim, N. D., Yu, B.P., and Chung, H. Y.: Redox Status of Serum in Aging Process. 대한약학회(1999)


    6. Kim, H.Y., Kim, J. W., Yang, Y. H., Kang, M. J., Yu, B. P., and Chung, H.Y. : Gene Expression of Heme Oxygenase in the Aging Process, 대한약학회(1999)


    7. Lee, Y. M., Jeong, C. H., Koo, S. Y., Son, M. J., Song, H. S., Raleigh, J.A., Chung, H.Y., Yoo, M.A., and Kim, K. W. : The angiogenesis during development is regulated by local hypoxia in vivo. 대한약학회(1999)


    8. Chung, H.Y., Choi, W. S., Oguchi, T., and Yamamoto K. : Formation of fine Particles of Slightly Soluble Medicines by Planetary Ball Milling(2): Effect of Guest Species on lnclusion Compound Formation of Ursodeoxycholic Acid by Co-Grinding. 대한약학회(1999)


    9. Chung, H. Y.: MOLECULAR MECHNISM OF CALORIE RESTRICTION FOR THE ANT-INFLAMMATOTY ACTION. The Korean Society for Gerontology(2000)


    10. Beak, J. H., Kim, M.S., Jang, J.E., Kwon, H. J., Kim, Y. J., Chung, H.Y., and Kim, K.W. : TRICHOSTATIN A, A SPECIFIC INHIBITOR OF HISTONE DAECETYLASE, ENHANCES CYCLOOXYGENASE-2 EXPRESSION AND INDUCES APOPTOSIS IN HUMAN HEPATOBLASTOMA CELLS. The Korean Society for Gerontology(2000)


    11. Chung, H.Y., Yu, B. P., and Yoon, J. S.,: INVESTIGATION ON NATURAL PEROXYNITRITE SCAVENGERS. The Korean Society for Gerontology(2000)


    12. Chung, H.Y., Kim, A.R., Choi, J.S., Yu, B.P. : Inhibition of peroxynitrite-induced nitration by coffee ingredients: Effect on glutathione reductase. The Korean Society for Gerontology(2000)


    13. Choi, H. R., Park, H. J., Choi, J. S., Sohn, B.W., Choi, W.C., Lim, W.K., Jung, J.H., Lim, K.S., and Chung, H.Y.,: IDENTIFICATION OF ACTIVE INGRDIENTS OF ALGAE AGAINST REACTIVE SPECICES. The Korean Society for Gerontology(2000)


    14. Kim, J.W., An, H. J., Park, K.J., Cho, E.J., Yokozawa, Takako. and Chung, H.Y.: IDENTIFICATION OF HERBS FOR OXIDANT SCACENGING ACTIVITIES. The Korean Society for Gerontology(2000)


    15. No, J. K., Soung, D.Y., Park, J. S., Kim, M. J., Choi, J.H. Yang, R. Yu, B.P. and Chung, H. Y.: STRUCTTRE REQUIREMENT OF HYDROXYL GROUP FOR ENDOGEOUS INDOLE ANTIOXIDANTS. . The Korean Society for Gerontology(2000)


    16. Chung, H.Y., Kim, H.J., Yang, Y.H., Choi, W. C., Park, H. J., Choi, J. S., Kang, C. M., and Park, S. C. : PROTECTION OF MITOCHONDRIA PERMEABILITY TRANSITION BY DIHYDROXYBENZALDEHYDE AGAINST HYDRIXYL RADICALS. The Korean Society for Gerontology(2000)


    17. Woo, J. S., Chung, H. Y., Kim, K. C., Jung, J. S., and Kim, Y. K. : PROTECTION BY ADENOSINE AGAINST HYDPOGEN PEROXIDE-INDUCED INJURY IN RENAL EPITHELIAL CELLS. Korea. The Korean Society for Gerontology(2000)


    18. No, J. K., Kim, H. J., Yu, B. P., and Chung, H. Y. : AGE-RELATED INCRAES OF GAS PEROXIDASE WITHOUT CHANGING GENE EXPRESSION. The Korean Society for Gerontology(2000)


    19. Kim, H. J., Jeong, H. Y., Yu, B. P., Goto, Sataro., and Chung, H. Y.:ANALYSIS ON PROTEINS IN AGED RAT KIDNEY: THE EFFECT OF CALORIERESTRICTION. Korea. The Korean Society for Gerontology(2000)


    20. Kim, H. J., Yu, B. P., Yu, M. A., Lim, K.W., Woo, J. S., and Chung, H. Y. : CONTRIBUTION OF CYCLOOXYGENASE TO AGE-RELATED OXIDATIVE STRESS. The Korean Society for Gerontology(2000)


    21. Kim, H. J., Yu, B. P., Jung, M. H., Han, B. G., Kim., N. D., and Chung, H. Y. : AGE-RELATED UP-REGULATION OF NF ?Kb AND MODULATION BY CALORIE RESTRICTION. The Korean Society for Gerontology(2000)


    22. Kwon, H. J., Kang, M. J., Yu, B. P., Jung, M. H., Han, B. G., and Chung, H.Y.: EFFECT OF ON XANTHINE GENE EXPRESSION IN RAT BRAIN. The Korean Society for Gerontology(2000)


    23. Kwon, H. J., Kang, M. J., Kim, H. J., Yu, M. A., Kim, K. W., Yu, B. P., Woo, J. S., and Chung, H.Y. : EXPRESSION OF HIF-1 INDUCLBLE GENES IN THE AGED RAT BRAIN. The Korean Society for Gerontology(2000)


    24. Kim, J. W., No, J. K., Yu, B. Y., and Chung, H.Y.: ANALYSIS ON REDOX STATUS IN SERUM DURING AGING, The Korean Society for Gerontology(2000)


    25. Kim, J. W., Kim, K. W., Choi, W. C., Yu, B. P., Lim, B. Y., Kim, Y. K., Herlihy Jeremiah T. and Chung, H.Y.: AGE-MODULATED OXIDATIVE STAUS OF RAT AORTA. The Korean Society for Gerontology(2000)


    26. Kwon, H. J., Kim, H. J., Kang, M. J., Takagashi, Ryoya., Goto, Sataro., Yu, B. P., and Chung, H.Y.: THE ACTIVATION MECHANISMS OF NF-Kb AND INFLAMMATORY ENZYMES DURING AGING.. The Korean Society for Gerontology(2000)


    27. Kwon, H. J., Kim, H. J., Kang, M. J., Takagashi, Ryoya., Goto, Sataro., Yu, B. P., and Chung, H.Y.: EFFECTS OF AGE AND LIPOPOLYSACCHARIDE ON THE PRODUCTION OF PROINFLAMMATORY CYTOKINES IN RAT LIVER. The Korean Society for Gerontology(2000)


    28. Kim, A.R., Choi, J.S., Yu, B.P., Chung, H.Y.: Inhibition o f Peroxynitrite-induced nitration by coffee Ingredients: Effect on Glutathione Reductase. The Pharmaceutical Society of Korea(2000)


    29. Kang, M. J., Yu, M. A., Kim, K. W., Yu, B. P., Woo, J. S., and Chung, H. J.: Expression of HIF-1 inducible genes in the aged rat brain. The Pharmaceutical Society of Korea(2000)


    30. Lee, J. H., Lansky, E. P., Jung, J. H., Kim, M. D., Kim, D. K., Chung, H. Y., and Kim, N. D.,: Effects of pomegranate (Punica granatum) Polyphenol fraction on proliferation of estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) human breast cancer cells. The pharmaceutical Society of Korea(2000)


    31. Kim, H. J., Yu, B. P., and Chung, H.Y.: Age-related up-regulation of NF-kappaB and modulation by calorie restriction. The pharmaceutical Society of Korea(2000)


    32. Kim, S. H., Kang, H. K., Chung, H. Y., Choi, Y. H., and Kim, N. D,.: Apoptotic Death in MDA-MB-231 Human Breast Cancer Cell lnduced by Trichostatin A. The pharmaceutical Society of Korea(2000)


    33. Yoon, J. S., Choi, H. R., Park, H. J., Choi, J. S., Choi, W. C., and Chung, H. Y.,: Peroxynitrite scavenging and cytoprotective activity of 2,3,6,-tribromo-4,5-dihydroxy benzyl methyl ether from marine alga Symphyocladia latiuscula. NEW STRATEGY FOR DRUG DEVELOPMENT IN POST GENOMIC ERA, 대한약학회(2000)


    34. Kang, H. K., Lee, J. H., Im, H. S., Chung, H. Y., Yu, B. P., and Kim, N. D.: Effects of aging and dietary restriction on the extracellular matrix proteins of rat tissues. NEW STRATEGY FOR DRUG DEVELOPMENT IN POST GENOMIC ERA, 대한약학회(2000)


    35. Chung, H.,Y., and Kim, H. J.: The Inflammation Hypothesis Aging: Molecular Modulation by Calorie Restriction. Fall Symposium on Molecular Aspects of Human Diseases at the Post-Genomic Era.(2000)


    36. Kang, H. K., Lee, J. H., Im, E. O., IM, H. S., Chung, H. Y., Yu, B.P., and Kim, N. D.,: Effect of aging and Dietary restriction on the apoptosis related genes of rat testis. PROCEEDUNGS OF THE PHARMACEUTICAL SOCIETY OF KOREA, 대한약학회(2001)


    37. Lee, J.H., Kang, M.J., Park, T.H., Jung, K.J., Kim, H.J., Choi, J.S., Chung, H.Y. : Expression of HIF-1 inducible genes in the aged rat liver. PROCEDDINGS OF THE PHARMACEUTICAL SOCIETY OF KOREA, 대한약학회(2001)


    38. Jung, M. J., Kim, J. E., Choi, J. H., Chung, H. Y., Jung, J. H., and Choi, J. S.: A rare C-methylated glycoside from the leaves of Pinus densiflora. PROCEEDUNGS OF THE PHARMACEUTICAL SOCIETY OF KOREA(2001)


    39. Kim, H. J., Park, H. S., Park, T. H., and Chung, H.Y.: Influence of aging and calorie restriction on activation of MAPK. Biochemistry and Molecular Biology(2001)


    40. Chung, H.Y.: Development Strategy of Anti-aging Drugs Based on Inflammation Hypothesis of Aging. 노화혈관신생 심포지엄(2001)


    41. Lee, J. H., Kim, J. W., Zou, Y., Kim, N. D., Choi, J. S., and Chung, H. Y. : Induction of Apoptosis in Renal Aging. 한국분자세포생물학회(2001)


    42. Kim, A. R., Choi, J. S., and Chung, H. Y.: PEROXYNITRITE SCAVENGING BY NO MODULATORY ACTIVITIES OF HYDROQUINONE FROM COFFEE. Dietary and Medicinal Antimutagens and Anticarcinogens: Molecular Mechanisms and Chemopreventive Potential(2001)


    43. Kim, A. R., Zou, Y. N., Park, T. H., Choi, J. S., and Chung, H. Y. :,Peroxynitrite Scavenging Activity of Herb Extracts. Dietary and Medicinal Antimutagens and Anticarcinogens: Molecular Mechanisms and Chemopreventive Potential(2001)


    44. Zou, Y. Kim, A., Kim, J. E., Choi, J. S., Lee, K. H., and Chung, H. Y. : Peroxynitrite Scavenging Activity of Sinapic Acid from Brassica juncea. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    45. Sung, B., Jung, K. J., Song, H. S., Kim, K. W., Choi, J. S., and Chung, H. Y. : Screening Age-related Genes by DNA-RNA. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    46. Lee, J.H., Kim, A., Kim, J. Y., Kim, C. H., Park, D. U., Han S. K,. Shimokawa, Isao. and Chung, H. Y., : Modulation of Oxidative Status by Calorie Restriction in Mini rat. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    47. Kim, H. J., Jung, K. J., Kim, J. Y., and Chung, H. Y. : Modulation of Redox-sensitive Transcription Factor, Ap-1 by Aging and Calorie Restriction. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    48. Jung, H. A., Kim, A. R., Chung, H. Y., and Choi, J. S.: Antioxidant Principles from the Leaves Prunus serrulata var. spontanea. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    49. Jung, M. J., Kim, A., Zou, Y., Chung, H. Y., and Choi, J. S. : Further Antioxidant Principles from the Needles of Pinus densiflora. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2001)


    50. Zou, Y., Kim, A., Park, T. H., Choi, J. S., and Chung, H. Y.: Peroxynitrite Scavenging Activity of Sinapic Acid, PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    51. Kim, A., Lee, J. H., Choi, J. S., Lee, K. H., and Chung, H. Y.: Hydroquinone from Coffee Modulates Reactivity of Peroxynitrite and Nitic Oxide Production. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    52. Kim, C. H., Park, D. U., Hong, S. E., and Chung, H. Y.: 2-DE/MALDI-TOF MS Analysis of Age-dependent Mitochondrial proteome in Rat Liver PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    53. Sung, B. K., Jung, K. J., Je, J. H., Lee, J. S., and Chung, H. Y., : Probing for Differentially Expressed Genes in Aged Monkey Muscle by cDNA-Representational Difference Analysis. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    54. Jung, K. J. Ishigami, Akihito. Maruyama, Naoki., Chung, H. Y.: Down-regulation mechanism of Senescence Marker Protein 30 by ROS during aging. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    55. Jung, K. J., Kim, H. J., Yu, B. P., Chang, G.Y., and. Chung, H. Y: Regulation of Redox-sensitive Transcription Factors in aging process.: PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    56. Jung, K. J., Kim, H. J., Yu, B. P., and Chung, H. Y.: Influence of Aging on MAPKs Activity in Rat Kidney. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    57. Choi, J. S., Kim, J. E., Jung, M. J., Woo, J. J., and Chung, H. Y.: A New flavonol glycoside from Brassica juncea L. PROCEEDINGGS OF INTERNATIONAL CONVENTION OF THE PHARMACETICAL SOCIETY OF KOREA(2002)


    58. Sung, B., Jung, K. J., Park, T. H., and Chung, H. Y.: Screening of Renal Age-related Biomarkers by cDNA-Representional Difference Analysis. Bioscience in the Postgenome Era(2002)


    59. Kim, C. H., Park, D. U., Hong, S. E., Chung, A. S., and Chung, H. Y.: 2-DE/MALDI-TOF MS Analysis of Age-dependent Mitochondrial Proteome in Rat Liver. Bioscience in the Postgenome Era(2002)


    60. Park, D. U., Kim, C. H., Hong, S. E., Jung, A. S., Chang, G. Y. and Chung, H. Y.: The 2-DE Image Analysis Software in the Proteomics. Bioscience in the Postgenome Era(2002)


    61. Jung, K. J., Kim, H. J., Yu, B. P., Chung, G. Y. and Chung, H. Y.: Regulation of Redox-sensitive Transcription Factors its Modulation by Calorie Restriction during Aging. Bioscience in the Postgenome Era(2002)


    62. Jung, K J., Sung, B., Kim, C. H., Kim, D. H., Ishigami, Akihito., Maruyama, Naoki., and Chung, H. Y.,: Transcriptional Regulation of Senescence Marker Protein 30 by Age and Calorie Restriction.: Bioscience in the Postgenome Era(2002)


    63. Kim, C. H., Park, D. U., Hong, S. E., Chung, A. S., and Chung, H. Y.: Differential 2DE Analysis of Kidney Tissue in Aged and LPS-treated Rats. The 59th Annual Fall Meeting(2002)


    64. Sung, B., and Chung, H. Y.: Identification of Genes with Up- and Down-regulated in Rat Kidney during Aging Process. The 59th Annual Fall Meeting(2002)


    65. Hong, S. E., Kim, C. H., Park, D. U., Yu, B. P. and Chung, H. Y.: Biological Information Graphic Arts Handbook: Novel Retrieving System for Macroscopic and Efficient Understanding of Biological Process. The 59th Annual Fall Meeting(2002)


    66. Sung, B. K., Kang, S. J., and Chung, H. Y.: Microarray Analysis of Gene Expression in the Aging Rat Kidney. The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2002)


    67. Kim, C. H., Park, D. U., Hong, S. E., Chung, H. Y., and Chung, A. S.: Differential 2DE Analysis of Kidney Tissue in Aged and Inflammation-induced Rats with LPS. The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2002)


    68. Park, D. U., Lee, J. H., Kim, C. H., Hong, S. E., Yu, B. P., and Chung, H. Y.: Aging DB: A Database for Oxidative Stress and Calorie Restriction in the Study of Aging. . The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2002)


    69. Park, D. U., Kim, C. H., Hong, S. E., Yu, B. P., Choi, J. S., and Chung, H. Y.: Development of Aging-related Biomolecular Database and Protein Interaction Visualization. Korean Society for Bioinformatics Annual Meeting(2002)


    70. Hong, S. E., Kim, C. H., Park, D. U., Yu, B. P., and Chung, H. Y.: Gene Handbook: Novel Retrieving System for Macroscopic and Efficient Understanding of Biological Process. . Korean Society for Bioinformatics Annual Meeting(2002)


    71. Cho, H. G., Park, D. U., Kwon, H. C., and Chung, H. Y.: A Novel System for Information Extraction of Protein Interactions Based on Aging-Related Corpus. . Korean Society for Bioinformatics Annual Meeting(2002)


    72. Park, D. U., Kim, C. H., Hong, S. E., Jung, A. S., and Chung, H. Y.: The 2-DE Image Analysis in the Proteomics using Matlab. . Korean Society for Bioinformatics Annual Meeting(2002)


    73. Kim, C. H., Park, D. U., Hong, S. E., Chung, A. S., and Chung, H. Y.,: The Proteome Information 2-D PAGEL Database of Aging Tissues. . Korean Society for Bioinformatics Annual Meeting(2002)


    74. Sung, B. K., Park, D. U., Hong, S. E., and Chung, H. Y.: Microarray Analysis of Gene Expression in the Aging Rat Kidney. . Korean Society for Bioinformatics Annual Meeting(2002)


    75. Park, T.H., Jung, H.A., Choi, J.S., Chung. H.Y.: Peroxynitrite Scavenging Mechanism of Alaternin and Nor-rubrofusarin glucose from Cassia tora. PROCEDDINGS OF THE 51st ANNUAL CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2002)


    76. Kang, H. S., Kim, H.R., Chung, H.Y., Choi, J.S. : Tyrosinase Inhibiting and DPPH Radical Scavenging Activities of Rosmarinic Acid and Its Methyl ester from Salvia miltiorrhiza. PROCEDDINGS OF THE 51st ANNUAL CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2002)


    77. Jung, H.A., Chung, H.Y., Choi, J.S. : In vitro antioxidant triterpenoids from Prunus serrulata var. spontanea. PROCEDDINGS OF THE 51st ANNUAL CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2002)


    78. Jung, K.J., Zou, Y., Kang, S.J., ISHIGAMI Akihito, MARUYAMA Naoki, Chung, H.Y. : Down-Regulation of Senescence Marker Protein-30 by ROS during Aging. The 14th ANNUAL Meeting of the Korea Society for Molecular and Cellular Biology. (2002)


    79. Yang, D.J., Kim, Y.S., Park, J.H., Kang, H.S., Baek, H. S., Chung, H.Y., Yoo, M.A.: STAT is Involved in Defense Response to Oxidative Stress. 한국유전학회 (2002)


    80. 김영신, 남혁진, 정해영, 김남득, 유미애 : 초파리 선천성 면역 반응에 있어서의 xanthine dehydrogenase의 역할. 한국생명과학회 35회 학술심포지엄(2002)


    81. Choi, W.S., Kwak, S.S., Kim, H.I., Chung, H.Y., Chung, H.-Y., K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi, and K. Terada. : Amorphous and Nano-particle Preparation for Improvement of Insoluble drugs bioavailability: Grinding Characteristics of Fine Grinding Mills. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy (2002).


    82. Song, S.W., Jung, J. S., Ki m, Y.K., Chung, H.Y., Woo, J.S. : A1 Receptor-mediated Protection from Oxidant-induced Cell Injury and Mitochondrial Dysfunction in Human Neuroglioma Cells. 대한 생리학회 학술대회 (2002)


    83. Sung, B., Donald K. Ingram, George S. Roth, Mark A. Lane, Chung, H.Y. : Probing for Differentially Expressed Genes in Aged Monkey Muscle by cDNA-Representational Difference Analysis. 2002 Conference of age Society of Korean Gerontology(2002)


    84. Jung, K.J., Akihito Ishigami, Naoki Maruyama, Sataro Goto, Yu, B.P., Chung, H.Y. : Transcriptional Regulation of Senescence Marker Protein 30 by Age and Calorie Restriction. 2002 Conference of the Society of Korean Gerontology(2002)


    85. Yee, S.B., Chung, S.W. Im, H.S., Chung, H.Y., Kim N.D.: EFFECTS OF AGING AND CALORIE RESTRICTION ON THE LEVELS OF APOPTOSIS AND CELL CYCLE RELATED PROTEINS OF RAT TISSUES. 2002 Conference of the Society of Korean Gerontology(2002)


    86. Chung, H.Y.: Involvement of Inflammatory Reaction in the Aging Process and its Modulation by Ginsenoside Rd. The Korean Society of Ginseng(2002)


    87. Chung, H. Y.: Molecular Inflammation as the Underlying Mechanism for the Aging Process. Anti-aging Action of Calorie Restriction. 2003 Conference of the Korean Society for Gerontology(2003)


    88. Kim, C.H., Zou, Y., Jung, A.S., and Chung, H.Y.: Proteomic Analysis of Nitrated And HNE-adducted Proteins From Young and Old Rat Serum. The 15th annual Meeting of the Korean Society for Molecular and Cellular Biology (2003)


    89. Choi, N.H., Hwang, M.S., Park, S.Y., Park, J.H., Kim, Y.S., Kang, H.S., Chung, H.Y., and Yoo, M.A. : Salicylate Inhibits Function of the Caudal homeobox Gene. The 15th annual Meeting of the Korean Society for Molecular and Cellular Biology (2003)


    90. Lee. J.Y., Je, J.H., Chung, S.W., Sung, B., Kim, N.D., and Chung, H.Y.: 4-Hydroxyhexenal Induced Endothelial Cell Apoptosis through NF-κB Activation. The 15th annual Meeting of the Korean Society for Molecular and Cellular Biology (2003)


    91. Zou, Y., Kim, Y. J., Kim, J. Y., Kang, D. Y., Kim, N. D., Lee, K. H., and Chung, H. Y. : Alteration of Cellular Adhesion Molecules during Aging and Their Modulation by Calorie Restriction. Proceedings of the convention of the Pharmaceutical Society of Korea(2003)


    92. Chung, S. W., Yee, S.B., Choi, H.J., Park, S., Jung, K.J., Kim, D.H., Chung, H. Y., Kim, N.D.: 4-Hydroxy nonenal(HNE) Induces Endothelial cells Apoptosis via iNOS mediated ONOO- generation. Proceedings of the convention of the Pharmaceutical Society of Korea(2003)


    93. Kang, H. S., Chung, H. Y., Jung, J. H., Son, B. W., and Choi, J. S.,: A new Phlorotannin from the brown alga Ecklonia stolonifera. Proceedings of the convention of the Pharmaceutical Society of Korea(2003)


    94. Sung, B. K., Jung, K. J., Go, E. K., Lee, J. Y., Park, D. U., Hong, S. E., and Chung, H. Y.,: Microarray analysis of gene expression in the aging rat kidney. Discovery and Challenge in Bioscience(2003)


    95. Chung, H. Y., Choi, J. S., Park, T. H., and Sung, B.: Involvement of Molecular Inflammatory Process: Antioxidative and Anti-Aging Actions of nelumbo nucifera and its active components. The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists(2003)


    96. Chung, H. Y., Choi, J. S., Park, T. H., and Lee, J. Y.: Anti-aging action of nelumbo nucifera and its component based on molecular inflammation hypothesis of aging. The 9th International Symposium on Traditional Medicine (2003)


    97. Chung, H. Y.: Molecular inflammation as the underlying mechanism for the aging process: anti-aging action of calorie restriction. The International Meeting of the Society for Free Radical Research(SFRR)- Asia(2003)


    98. Chung, H. Y.: Molecular Inflammation as the Underlying Mechanism for the aging Process: Anti-aging Action of Calorie Restriction. The 7th Asia Oceania Regional Congress of Gerontology(2003)


    99. Kim, H.K., Kim, D.H., Park, S., Chung, H.Y.: Modulation of Chemokines, iNOS and HIF-1a by Sal in Rat Peritoneal Macrophages. 제48차 대한면역학회 춘계학술대회(2004)


    100. Lee. J.S., Kim, H.K., Lee, J. Y., Kang, D.Y., Choi, S.Y., Park, M.J., Chung, H.Y.: Cell migration signal Pathways by N-(3-Indolylacetyl)lL-Phenylalanine in Endothelial Cell. Proceedings of the Convention of the Pharmaceutical Society of Korea (2004)


    101. Chung, H. Y., Lee, J. Y., and Je, J. H. : Molecular Evidence of Reaction Aldehydes Support of Molecular Inflammation Hypothesis Aging. Spring Conference of the Korean Society for Gerontology and the 4th Korea-Japan Gerontologist Joint Meeting(2004)


    102. Zou, Y., Yoon, S., Yu, B. P., and Chung, H. Y.: Oxidative Stress Induces of Adhesion Molecules during Aging. Spring Conference of the Korean Society for Gerontology and the 4th Korea-Japan Gerontologist Joint Meeting(2004)


    103. Chung, H. Y., Lee, J. Y., and Je, J. H.: Molecular Evidence of Reactive Aldehydes in Support of Molecular Inflammation Hypothesis of Aging. The 6 th International symposium on Vascular Aging and Age-related Angiogenesis(2004)


    104. Zou, Y., Yoon, S. Yu, B. P., and Chung, H. Y.: Oxidative Stress Induces Activation of Adhesion Molecules during Aging. The 6th International symposium on Vascular Aging and Age-related Angiogenesis(2004)


    105. Kim, C.H., Zou, Y., and Chung, H.Y.: Application of Proteomic and Bioinformatic techniques to Aging Research. The 16th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2004)


    106. Sung, B., Park S., Chung, S.W., Park, M.J., and Chung, H.Y.: Amelioration of Age-related Inflammation and Oxidative Stress by PPARγ Agonist: Suppression of NF-?B by 2,4-Thiazolidinedione. The 16th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2004)


    107. Kim, H.K., Lee, J.S., Park, M.J., Chung, H.Y. and Chung, J.: Down-regulation of iNOS, TNF-? and RANTES Expression by Kaempferol via NF-?B Inactivation in Aged Rat Gingival Tissues. The 16th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2004)


    108. Kim, H.K., Lee, J.S., Par, M.J., Choi, S.Y., and Chung, H.Y.: Down-regulation of iNOS and COX-2 by Zingerone via NF-?B Pathway in Aged Rat Kidney. The 16th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2004)


    109. Kang, D.Y., Lee, J.Y., Kim, D.H., Zou, Y., and Chung, H.Y.:4-Hydroxynenenal Induces Endothelial Apoptosis through Mitochondrial Depolarization. The 16th Annual Meeting of the Korean Society for Molecular and Cellular Biology(2004)


    110. Kim, J. Y., Jung, K. J., Choi, J. S., and Chung, H. Y.: Modulation of Age-related NF-kB Activation by Hesperetin. Proceedings of the convention of the pharmaceutical society of Korea(2004)


    111. Kim, Y. J., Yokozawa, Takako., and Chung, H. Y.: Effects of calorie restriction and fish oil supplementation on renal guanidine levels and antioxidant defenses in B/W mice during aging. Proceedings of the convention of the pharmaceutical society of Korea(2004)


    112. Park, S., Sung, B., Yu, B.P., and Chung, H. Y.: Inhibitory Action of salicylideneamino-2-thiophenol on NF-?B signaling Cascade and cyclooxygenase-2. Proceedings of the convention of the pharmaceutical society of Korea(2004)


    113. Chung, H. Y.: Modulation of NF- ?B Signaling Cascade in the Aging Process by Calorie Restriction. Biomedical gerontology(2004)


    114. Chung, H. Y.: Anti-inflammatory Calorie Restriction Suppresses oxidatively modified NF-kB Signaling during Aging. Korea Conference on Innovative Science and Technology (2004)


    115. Zou, Y., Kim, J. W., Yu, B. P., and Chung, H. Y.: Activation of Proinflammatory Genes is Responsible. Korea Conference on Innovative Science and Technology (2004)


    116. Park, J.H., Choi, N.H., Hwang, M.S., Hwang, Y.J., Kang, H.S., Chung, H.Y., Kim, Y.S., Yoo, M.A.: LIGHTENING EFFECT ON CAUDAL HOMEODOMAIN PROTEIN-INDUCED PIGMENTATION BY SALICYLATE IN DROSOPHILA. 14TH International Congress on Photobiology (2004)


    117. Go, E.K., Jung, K. J., Kim, J. Y., and Chung, H. Y.: Betaine modulates NF-κB signaling pathway through enhancement of thiols. Proceedings of the convention of the pharmaceutical society of Korea(2005)


    118. Sung, B., Park, S., and Chung, H.Y.: Clofibrate Reduces Age-induced Activation of Redox-Sensitive Transcription Factors, NF-κB and AP-1. Proceedings of the convention of the pharmaceutical society of Korea(2005)


    119. Jung, K.J., Go, E. K., Kim, J.Y., Chung, H.Y.: Molecular modulation of ferulate on age-related changes in NF-κB and its gene expression. Proceedings of the convention of the pharmaceutical society of Korea(2005)


    120. Chung, H.Y.: Molecular Inflammation and Oxidative Stress as the Underlying Mechanism of Aging Process. 한국노화학회 춘계학술대회(2005)


    121. Park S., and Chung H.Y.: Suppression of NF-κB signaling cascade and Cyclooxygenase-2 by salicylideneamino-2-thiophenol. 한국노화학회 춘계학술대회(2005)


    122. Kim, J.Y., and Chung, H.Y.: Hesperetin modulates the age-related nuclear factor B (NF-κB) pathway. 한국노화학회 춘계학술대회(2005)


    123. Sung, B., and Chung H.Y.: Modulation of Age-related Microinflammation by PPAR Agonist 2,4-Thiazolidinedione. 한국노화학회 춘계학술대회(2005)


    124. Jung, K.J., and Chung, H.Y.: Molecular exploration of ferulate on age-related NF-κB signaling and proinflammatory gene expression. 한국노화학회 춘계학술대회(2005)


    125. Go, E.K., and Chung H.Y.: Betaine modulates pro-inflammatory NIK/IKK/NF-κB signaling during aging. 한국노화학회 춘계학술대회(2005)


    126. Chung, H.Y.: Molecular Inflammation as the Underlying Mechanism of Aging Process and Its Intervention by Photochemicals. 2005 Agricultural Biotechnology Symposium(2005)


    127. Zou, Y., Jung, K.J., Kim, J.W., Yu, B.P., and Chung, H.Y: Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. The 7th symposium on Vascular Aging and Bioinformatics (2005)


    128. Heo, H.S., and Chung, H.Y.: A Simple and Flexible Method for Gene and Protein Nomenclature Recognition from Biomedical Literature. Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI (2005)


    129. Park, D.W., Heo H.S., Kwon, H.C., Chung, H.Y.: Protein function Prediction using Probabilistic classification Method. Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI (2005)


    130. Kim, C.H., and Chung. H. Y.: Application of Proteomic and Bioinformatic Techniques to Aging Research. Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI (2005)


    131. Kim, C.H., and Chung. H. Y.: dbPIAT : a Database of Proteome Information of Aged Tissues. Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI (2005)


    132. Kwon, J.K. and Chung, H.Y.: Database of Age-Related Transcription regulatory Elements. Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI (2005)


    133. Kim, N.D., Copple, B.L., Kang, M.J., Kim, J.M., and Chung, H.Y: Role of Hypoxia and Egr-1 in the Aging Liver. 한국노인과학학술단체연합회 2005년도 추계연합학술대회 (2005)


    134. Kim, C.H., Kwon, J.K., Heo, H.S., and Chung, H.Y.: dbPIATDatabase of Proteome Information of Aged animal model’s Tissues. 한국노인과학학술단체연합회 2005년도 추계연합학술대회 (2005)


    135. Kwon, J.K., Heo, H.S., Kim, C.H., and Chung, H.Y: Integration system for ageing research based on distance analysis between factors. 한국노인과학학술단체연합회 2005년도 추계연합학술대회 (2005)


    136. Kim, D.H., Kim, J.Y., Zou, Y., Kim, Y.J., and Chung, H.Y.: Short-term feeding of baicalin inhibits age-associated NF-κB activation. 한국노인과학학술단체연합회 2005년도 추계연합학술대회 (2005)


    137. Jung, K.J., Go, E.K., Kim, Y.J., and Chung, H.Y.: Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-B in aged rats. 한국노인과학학술단체연합회 2005년도 추계연합학술대회 (2005)


    138. Lee, J.S., Kim, S. G., Yoon, M.S., Kim H.K., Lee, T.H., Lee, C.M., Jeong, Y.I., Ahn S. C., Lee, S.Y., Kim, B.H., Moon, Y., Park, Y.C., Kim, Y. B., Chung, H.Y., Park, Y.M. : SB Inhibits Immunostimulatory Function of Dendritic Cells; MAPKs and translocation of NF-κB as potential targets. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    139. Sung, B., Park S., Chung H.Y.: Amelioration of age-related inflammation and oxidative stress by PPARγ activator: Suppression of NF-κB by 2,4-thiazolidinedione. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    140. Go, E. K., Jung, K.J., Kim, Y.J., Chung, H.Y.: Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-κB in aged rats. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    141. Kwon, J.K., Heo, H.S., Kim, C.H., Chung, H.Y.: Integration system for ageing research based on distance analysis between factors. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    142. Kim, C.H., Kwon, J.K., Heo, H.S., Chung, H.Y.: dbPIATDatabase of Proteome Information of Aged animal model’s Tissues. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    143. Kim, D.H., Kim, J.Y., Zou, Y., Chung, H.Y.: Short-term feeding of baicalin inhibits age-associated NF-κB activation. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    144. Heo, H.S., Chung, H.Y.: Construction of Thesaurus for Human Gene and Protein Nomenclatures. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    145. Kim, C.H., Kwon, J.K., Heo, H.S., Chung, H.Y.: Application of Proteomic and Bioinformatic Techniques to Aging Research. PROCEEDING OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2005)


    146. Kwon, J.K., Chung, H.Y.: DBARTRE: DataBase of Age-Related Transcriptional Regulatory Elements. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    147. Kim, C.H., Go, E.K., Kim, J.Y., Jung, K.S., Chung, H.Y.: Application of Proteomic and Bioinformatic Techniques to Aging Research. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    148. Park, M.J., Sung, B., Go, E.K., Choi, J.S., Chung, H.Y.: Modulation of Age-related NF-κB Activation by Kaempferol. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    149. Sung, B., Choi, Y., Lee J., Chung, H. Y.: Modulation of Age-related Microinflammation by PPARγ Agonist 2,4-Thiazolidinedione. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    150. Go, E.K., Jung, K.J., Kim, D.H., Chung, H.Y.: Betaine modulates vascular inflammation during aging. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    151. Kim. J.Y., Jung, K.J., Chung, H.Y.: Molecular modulation of the age-related nuclear factor κB(NF-κB)pathway by hesperetin. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    152. Choi, S.Y., Kim, J.Y., Kim, D.H., Lee, J. Choi, J.S., Chung, H.Y.: 3-Methyl-1,2-cyclopentanedione Modulates Age-related NF-κB Signaling via PPAR Activation. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    153. Park, S.J., Kim, J.Y., Kim, J.M., Kim, Y.J., Chung, H.Y.:Salicylideneamino-2-thiophenol Modulates Redox Sensitive NF-κB through Redox Regulation during Aging Process. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2006)


    154. Zou, Y., Go, E.K., Kim, J.Y., and Chung, H.Y.: Mechanism of Lysophoshatidylcholine in Upregulation of endothelial Adhesion Molecules: involvement of GPR4. 63rd KSBMB Annual Meeting in 2006(2006)


    155. Chung, H,Y,: Calorie restriction modulates redox-sensitive transcription factors during aging. Biomedical Gerontology (2006)


    156. Go, E.K. and Chung, H.Y.: Betaine modulates NF-kB signaling pathway during aging. Biomedical Gerontology (2006)


    157. Kim, J.Y. and Chung, H.Y.: Molecular modulation of the age-related Nuclear factor kB(NF-kB) by hesperetin. Biomedical Gerontology (2006)


    158. Chung, H.Y.: Importance of LPC and Adhesion Molecules in Vascular Aging: modulatory effects of calorie restriction. Asian Aging Conference for Longevity (2006)


    159. Zou, Y., Kim, J.M., Go, E.K., Kim, J.Y., and Chung, H.Y.: Mechanism of Lysophosphatidylcholine in Upregulation of Endothelial adhesion Molecules: Involvement of GPR4. 2006 Conference of the Korean Society for Gerontolgy and Institute of Pharmaceutical Science(2006)


    160. Go, E.K., Choi, Y., Jung, K.J., Kim, D.H., and Chung, H.Y.: Betaine Modulates Vascular Inflammation During Aging. 2006 Conference of the Korean Society for Gerontolgy and Institute of Pharmaceutical Science(2006)


    161. Chung, H.Y.: Molecular Inflammation as the Underlying Mechanism of Aging Process and Its Intervention by Photochemicals. The 8th International Symposium on Vascular aging and Age-related Angiogenesis (2006)


    162. Kim, J.Y., and Chung, H.Y.: Molecular Modulation of the age-related Nuclear Factor ?B pathway by hesperetin. The 8th International Symposium on Vascular aging and Age-related Angiogenesis (2006)


    163. Go, E.K., and Chung, H.Y.: Betaine Modulates NF-?B signaling pathway during aging. The 8th International Symposium on Vascular aging and Age-related Angiogenesis (2006)


    164. Chung, H.Y.: Vascular Aging and Inflammation. The 8th International Symposium on Vascular aging and Age-related Angiogenesis (2006)


    165. Hong, S.E., Kim, D.H., Yu, B.P., and Chung, H.Y.: Inferring the effect of calorie restriction on aging from large-scale data compendium. The 8th International Symposium on Vascular aging and Age-related Angiogenesis (2006)


    166. Kim, D.H., Kim, J.Y., Yu, B.P., and Chung, H.Y.: The activation of NF-?B through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2006)


    167. Go, E.K., Jung, K.J., Kim, D.H., Kim, M., Chung, H.Y.: Betaine modulates vascular inflammation by the suppression of lysophosphatidylcholine in vascular aging. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2006)


    168. Choi, S.Y., Kim, J.Y., Kim, D.H., Kim, M., Choi, J.S., and Chung, H.Y.: Modulation of Age-related NF-?B Signalin via PPAR activation by 3-Methyl-1,2-cyclopentanedione. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2006)


    169. Park, M.J., Go E.K., Kim, M., Sung. B., Choi, H.S., Chung, H.Y.: Kaempferol modulates age-related NF-?B activation. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2006)


    170. Kim D.H., Kim, J.Y., Yu, B.P., Chung, H.Y.: The Activation of NF-κB through AKT-Induced FOXO1 Phosphorylation during Aging and it’s Modulation by Calorie Restriction. The 8th ILSONG International symposium and 2006 Conference of the Korean society for Gerontology(2006.12.15)


    171. Go, E.K., Jung, K.J., Kim, D.H., Kim, M.S., Chung, H.Y.: Betaine Modulates Vascular Inflammation by the Suppression of Lysophosphatidylcholine during Aging. The 8th ILSONG International symposium and 2006 Conference of the Korean society for Gerontology(2006)


    172. Jung, K.J., Go, E.K., Sung, B., Chung, H.Y.: Significance of PTK/PTP Shift in the Inflammatory Process: Regulating NF-κB Signaling during Aging. The 8th ILSONG International symposium and 2006 Conference of the Korean society for Gerontology(2006)


    173. Park, M.J., Go, E.K., Kim, M.S., Sung, B., Choi, J.S., Chung, H.Y.: Kaempferol modulates age-related NF-?B activation. The 8th ILSONG International symposium and 2006 Conference of the Korean society for Gerontology(2006)


    174. Choi, S.Y., Kim, J.Y., Kim, D.H., Kim, M.S., Choi, J.S., Chung, H.Y.: Modulation of Age-related NF-κB Signaling VIA PPAR Activation by 3-methyl-1,2-Cyclopentanedione. The 8th ILSONG International symposium and 2006 Conference of the Korean society for Gerontology(2006)


    175. Kim, J.Y., Kim, D.H., Kim, J.M., Lim, H., Lim, H.K., Go, E.K., Choi, Y.K., Chung, H.Y.: Modification of Age-related SREBP-1, PPARs, ATGL, and LPL by Short-term CR. The 18th Conference of the Korean Society for Gerontology(2007.05.11)


    176. Kim, J.M., Go, E.K., Lim, H., Lim, H.K., Choi, Y.K., Lee, J., Chung, H.Y: Kaempferol Modulates Age-related NF-κB Activation via RAGE-PKCβⅡ Signaling Pathway. The 18th Conference of the Korean Society for Gerontology(2007.05.11)


    177. Choi, Y.J., Lim, H., Go, E.K., Lim, H.K., Choi, Y.K., Chung, H.Y: Modulation of Age-related PI3K/AKT/FOXO Signaling Pathway by Ferulate. The 18th Conference of the Korean Society for Gerontology(2007.05.11)


    178. Choi, Y.J., Go, E.K., Lim, H., Lim, H.K., Choi, Y.K., Chung, H.Y: Modulation of Age-related PI3K/AKT/FOXO Signaling Pathway by Ferulate. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2007.05.11)


    179. Kim, J.Y., Kim, D.H., Kim, J.M., Lim, H., Lim, H.K., Go, E.K., Choi, Y.K., Chung, H.Y.: Modification of Age-related SREBP-1, PPARs, ATGL, and LPL by Short-term CR. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2007.05.11)


    180. Kim, D.H., Kim, J.Y., Kim, J.M., Choi, Y.J., Lim, H., Lim, H.K., Choi, Y.K. and Chung, H.Y.: The activation of NF-kappakB throught Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. 19th FAOBMB Seoul conference (2007.05.27-30)


    181. Choi, Y.J., Go, E.K., Lim, H., Lim, H.K., Choi, Y.K. and Chung, H.Y.: Modulation of age-related PIK/Akt/FOXO singnaling pathway by ferulate. 19th FAOBMB Seoul conference (2007.05.27-30)


    182. Kim, J.M., Go, E.K., Lim, H., Lim, H.K., Choi, Y.K., Lee, J. and Chung, H.Y.:Kaempferol modulates age-related NF-kB activation via kaempferol modulates age-related NF-kB activation via RAGE-P KCβⅡ signaling pathway. 19th FAOBMB Seoul conference (2007.05.27-30)


    183. Chung, H.Y., Hong, S.E., Go, E.K., Kim, J.M., Lim, H.A., Lim, H.K.: Molecular and systems-biological Evidence for Molecular Inflammation during Aging. Biomedical Gerontology(2007.06.20-22)일본노화학회 삿뽀로


    184. Kim, J.M., Go, E.K., Lim, H., Lim, H.K., Choi, Y.K., Lee, J. and Chung, H.Y.: Kaempferol modulates age-related NF-kB activation via kaempferol modulates age-related NF-kB activation via RAGE-P KCβⅡ signaling pathway. Biomedical Gerontology(2007.06.20-22) 일본노화학회 삿뽀로


    185. Kim, D.H., Kim, J.Y., Kim, J.M., Choi, Y.J., Lim, H., Lim, H.K., Choi, Y.K. and Chung, H.Y.: The activation of NF-kappakB throught Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biomedical Gerontology (2007.06.20-22) 일본노화학회 삿뽀로


    186. Kim, J.Y., Kim, D.H., Kim, J.M., Lim, H., Lim, H.K., Go, E.K., Choi, Y.K., Chung, H.Y.: Modification of Age-related SREBP-1, PPARs, ATGL, and LPL by Short-term CR. Biomedical Gerontology (2007.06.20-22) 일본노화학회 삿뽀로


    187. Chung, H.Y.: Molecular Inflammation as the Underlying Mechanism for Vascular Aging and Radiation. The 9th International symposium on Vascular Aging: Hormesis and Radiation(2007.08.02,부산대 약대 시청각실)


    188. Kim, J.M., Lim, H. A., Lim, H.K., Lee, J., Choi, J.S.: Modulation of RAGE signaling by Kaempferol during Aging. PROCEEDINGS OF THE CONVENTION OF THE PHARMACEUTICAL SOCIETY OF KOREA (2007.11.07-08, 서울 교육 문화회관)


    189. Kim, J.Y., Kim, J.M., Lim, H. A., Lim, H.K., Lee, J., Chung, H.Y.:Correlation between age-related Inflammation and Visceral Lipid Accumulation via SREBP-1 and PPAR α/β. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    190. Jung, K.J., Go, E.K., Kim, J.Y., Sung, B., Kim, J.M., Lim, H. A., Lim, H.K., Kim, M.S., Lee, J., Chung, H.Y.: Effect of short-term calorie restriction on proinflammatory NF- kB and AP-1 in aged kidney of Fischer 344 rats. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    191. Hone, S. E., Kim, D.H., Heo, H.S., Go, E.K., Kim, J.Y., Lim, H. A., Lim, H.K., Kim, M.S., Kim, C.H., Lee, J., Chung, H.Y.: Revealing System-level Correlations between Aging and Calorie Restriction using a Mouse transcriptome. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    192. Kim, D.H., Kim, J.M., Lim, H.A., Lim, H.K., Kim, M.S., Kim, C.H., Lee, J., Chung, H.Y.: The Activation of NF-kB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    193. Kim, J.Y., Kim, J.M., Lim, H.A., Lim, H.K., Lee, J., Chung, H.Y.: Calorie restriction modulates visceral lipid accumulation and inflammation in ob/ob mice. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    194. Go, E.K., Jung, K.J., Kim, J.M., Lim, H.A., Lim, H.K., Kim, M.S., Lee, J., Chung, H.Y.: Betaine modulates age-related NF-kB by thiol-enhancing action. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    195. Lim, H.A., Kim, J.M., Lim, H.K., Lee, J., Chung, H.Y.: Baicalin and baicalein from S baicalensis modulate ROS-induced inflammation acting as PPARγ agonist. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    196. Chung, S.W., Kim, J.M., Lim, H.A., Lim, H.K., Kim, J.M., Lee, J., Chung, H.Y.: NF-kB activation and pro-inflammatory gene expressions by γ-irradiation in senescence marker protein-30 KO mice. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    197. Chung, S.W., Kim, M.K., Kim, D.H., Kim, J.M., Lim, H.K., Kim, M.S., Chung, H.Y.: Modulation of age-related inflammation by zingerone. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    198. Zou, Y., Kim, D.H., Go, E.K., Kim, J.M., Lim, H.A., Lim, H.K., Kim, M.S., Lee, J., Chung, H.Y.: Lysophosphatidylcholine, a regulator of oxidative stress in vascular aging. 2007 Autumn Conference of the Korean Society for Gerontology (2007.11.30. 서울대 의대)


    199. Chung, H.Y.: Molecular and Systems-biological Evidence of Age-related Inflammation. International Symposium on “Molecular Basis of aging and Age-related diseases”(2007.12.15-16, National Health Institute: 미국보건연구원, 워싱턴)


    200. Chung, S.W., Kim, J.Y., Go, E.K., Kim, J.M., Choi, J.H., Lim, H.A., Lim, H.K., Chung, H.Y.: Molecular Evidence on Activation on Inflammatory NF-kB Signaling Pathway by Ionizing Radiation. The 6th Annual Cytokines & Inflammation Conference (2008.01.28-29, Orlando Metropolitan Resort, Orlando, FL, USA)


    201. Chung, H.Y., Jung, K.J., Go, E.K., Kim, J.M., Lim, H.A., Lim, H.K., Yu, B.P.: Modification of Pro-inflammatory Molecular Markers by Aspirin Treatment in Aged Rats. The 6th Annual Cytokines & Inflammation Conference (2008.01.28-29, Orlando Metropolitan Resort, Orlando, FL, USA)


    202. Chung, H.Y., Zou, Y., Go, E.K., Kim, J.M., Lim, H.A., Lim, H.K., Yu, B.P.: Chronic Inflammation in Vascular Aging Anti-inflammatory Action of Calorie Restriction and dietary Betaine. The 6th Annual Cytokines & Inflammation Conference (2008.01.28-29, Orlando Metropolitan Resort, Orlando, FL, USA)


    203. Chung, H.Y., Go, E.K., Kim, J.M., Lim, H.A., Lim, H.K., Yu, B.P.: Molecular Inflammation as the Underlying Mechanism for the Aging Process: Anti-aging Action of Calorie Restriction. The 6th Annual Cytokines & Inflammation Conference (2008.01.28-29, Orlando Metropolitan Resort, Orlando, FL, USA)


    204. Chung, H.Y.: Molecular Inflammation and Lipid Accumulation as Underlying Cause of aging and Age-related Diseases. The 7th Symposium of Longevity Life Science and Technology Institutes (2008.02.15 상남국제회관)


    205. Go, E.K., Kim, J.M., Choi, J., Lim, H.K., Choi, E.K., Chung, H.Y.: Modulation of Age-related Vascular by Calorie Restriction and Betaine Treatment. PROCEEDINGS OF THE SPRING INTERNATIONAL CONVENTION (2008.04.30-05.03 제주도 국제 컨벤션 센터)


    206. Kim, J.Y., Kim, J.M., Lim, H.K., Lee, J.W., Chung, H.Y., Go, E.K.: Calorie Restriction Modulates Visceral Lipid Accumulation and Inflammation in Ob/ob Mice. PROCEEDINGS OF THE SPRING INTERNATIONAL CONVENTION (2008.04.30-05.03 제주도 국제 컨벤션 센터)


    207. Kim, J.Y., Go, E.K., Kim, J.M., Choi, J., Lim, H.K., Choi, E.K.: Modulation of Age-related Inflammation and Lipid Accumulation by Calorie Restriction. PROCEEDINGS OF THE SPRING INTERNATIONAL CONVENTION (2008.04.30-05.03 제주도 국제 컨벤션 센터)


    208. Go, E.K., Chung, S.W., Kim, J.Y., Kim, J.M., Choi, J., Lim, H.K., Choi, E.K., Anton, S.: Allylmethylsulfide Inhibits Activation of NF-kB signaling Induced by X-ray Irradiation in C57/BL6 Mice Kidney. PROCEEDINGS OF THE SPRING INTERNATIONAL CONVENTION (2008.04.30-05.03 제주도 국제 컨벤션 센터)


    209. Zou, Y., Kim, D.H., Go, E.K., Choi, J., Kim, J.M., Lim, H.K., Choi, E.K., Yu, B.P., Chung, H.Y.: Lysophostadialcholine, a Regulator of Oxidative Stress in Vascular aging. 2008 Spring conference of the Korean society for gerontology and AVDRC symposium, Yeungnam University(2008.05.15-5.16 영남대학교)


    210. Go, E.K., Zou, Y., Choi, J., Kim, J.M., Lim, H.K., Choi, E.K., Yu, B.P., Chung, H.Y.: Modulation of Age-related Vascular Inflammation by Calorie Restriction and Dietary. 2008 Spring conference of the Korean society for gerontology and AVDRC symposium, Yeungnam University(2008.05.15-5.16 영남대학교)


    211. Chung, S.W., Kim, J.Y., Go, E.K., Kim, J.M., Choi, J., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Molecular Delineation of γ-Ray-Induced NF-κB Activation and Pro-Inflammatory Genes in SMP30 KO Mice. PROCEEDINGS OF THE FALL INTERNATIONAL CONVENTION (2008.10.23-10.24 서울 교육문화회관)


    212. Kim, D.H., Go, E.K., Kim, J.M., Choi, J.H., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Effects of short-term Baicalin Dietary Supplementation on Foxo1 Modulation in aged Kidney. PROCEEDINGS OF THE FALL INTERNATIONAL CONVENTION (2008.10.23-10.24 서울 교육문화회관)


    213. Lim, H.A., Kim, J.M., Go, E.K., Choi, J., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Anti-Inflammatory Action of Baicalin and baicalein in Mediated by PPARγ Activation. PROCEEDINGS OF THE FALL INTERNATIONAL CONVENTION (2008.10.23-10.24 서울 교육문화회관)


    214. Zou, Y., Kim, J.M., Go, E.K., Choi, J., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Lysophostadialcholine Enhances Oxidative Stress via the 5-Lipoxygenase Pathway during Bascular Aging. PROCEEDINGS OF THE FALL INTERNATIONAL CONVENTION (2008.10.23-10.24 서울 교육문화회관)


    215. Chung, H.Y.: Molecular of Vascular Aging by Calorie Restriction and Betaine Treatment. 2008 Autumn Conference of the Korean society for Gerontology (2008.11.03 서울대 의대)


    216. Zou, Y., Go, E.K., Kim, J.M., Choi, J., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Lysophostadialcholine Enhances Oxidative Stress via the 5-Lipoxygenase Pathway during Bascular Aging. 2008 Autumn Conference of the Korean society for Gerontology (2008.11.03 서울대 의대)


    217. Chung, S.W., Go, E.K., Kim, J.M., Choi, J., Ha, Y.M., Lim, H.K., Choi, E.K., Chung, H.Y.: Upregulation of NF-kB signaling and pro-inflammatory mediators in γ-irradiated mice. 2008 Autumn Conference of the Korean society for Gerontology (2008.11.03 서울대 의대)


    218. Kim, J.M., Go, E.K., Choi, J., Ha, Y.M., Choi, E.K., Lee, J., Kim, N.D., Chung, H.Y.: Molecular Inflammation


    219. as the Underlying mechanism for γ/x-irradiated tissue damage. Korean Society of Radiation Bioscience KOREA-ITALY SYMPOSIUM (2008.11.06-07, 한국원자력연구원(대전)


    220. Chung, S.W., Kim, J.M., Go, E.K., Choi, J., Ha, Y.M., Choi, E.K., Lee, J., Kim, N.D., Chung, H.Y.: Molecular delineation of γ-ray-induced NF-κB activation and pro-inflammatory genes in SMP30 KO mice. Korean Society of Radiation Bioscience KOREA-ITALY SYMPOSIUM (2008.11.06-07, 한국원자력연구원(대전)


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    225. Lee, E.K., Heo, H.S., Choi, J., Kim, J.M., Ha, Y.M., Choi, E., Yu, B.P., and Chung, H.Y.: Molecular Basis of Aging- and X-irradiation-related Inflammation: Involvement of Endogenous Lipopolysaccharide. 7th Annual Cytokines & Inflammation (2009.01.29-01.30 미국 샌디에고)


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    227. Heo, H.S., Lee, E.K., Kim, J.M., Choi, J., Ha, Y.M., Choi, E., Han, Y.K., Kim, H.J., Chung, H.Y., Oh S. J.: Bioinformati Analysis of Transcriptional Regulatory Elements Pattern. 2009 PROCEEDINES OF THE SPRING INTERNATIONAL CONVENTION. The Pharmaceutical Society of Korea (2009.05.07-2009.05.08 대전 컨센터)


    228. Park, H.r., Kim, M.S., Gong, E.J., Kwack, S.J., Chung, h.Y., Kim, H.S., Lee, J.: Neurotoxic Effect of 2,5-hexanedione on Neural Progenitor Cells and Hipposcampus. 2009 PROCEEDINES OF THE SPRING INTERNATIONAL CONVENTION.The Pharmaceutical Society of Korea (2009.05.07-2009.05.08 대전 컨센터)


    229. Lim, H.A., Lee, E.K., Heo, H.s., Choi, J., Kim, J.M., Ha, Y.M., Ghoi, E., han, Y.K., Kim, H.J., Yu, B.P., Chung, H.Y.: Baicalein Exhibits Anti-inflammatory Response through PPARγ Activation. 2009 PROCEEDINES OF THE SPRING INTERNATIONAL CONVENTION. The Pharmaceutical Society of Korea (2009.05.07-2009.05.08 대전 컨센터)


    230. Lee, E.K., Heo, H.s., Choi, J., Kim, J.M., Ha, Y.M., Choi, E., Han, Y., Kim, H.J., Yu, B.P., Chung, H,Y.: Involcement of Endogenous Lipoplysacchaeide in Age-related and X-irradiation- induced Inflammation: Aging and X-irradiation- induced Inflammatory Response through Endogenous Lipopolysaccharide. 2009 PROCEEDINES OF THE SPRING INTERNATIONAL CONVENTION. The Pharmaceutical Society of Korea (2009.05.07-2009.05.08 대전 컨센터)


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    232. Hae Yung Chung.: Molecular inflammation as the underlying mechanism of aging: involvement of ONOO- and LPS. The 66th KSBMB Annual Meeting 2009. Korean Society for Biochemistry and Molecular Biology (2009.05.12~13 서울 벡스코)


    233. Heo, H.S., Lee, E.K., Kim, J.M., Choi, J., Ha, Y.M., Choi, E., Chung, H.Y., Oh, S.J.: TREP_DB: tanscriptional regulatory elements pattern database. The 66th KSBMB Annual Meeting 2009. Korean Society for Biochemistry and Molecular Biology (2009.05.12~13 서울 벡스코)


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    236. Kim, J.M., Lee, E.K., Heo,H.S., Choi,J., Ha, Y.M., Choi, E., Chung, H.Y.: Moelculam mechanism of γ/χ-irradiated tissue damage in C57/BL6 mice. 2nd Asian Congress of Radiation Research 2009. Korean Assiociation for Radlation Research (2009.05.17~20 서울 벡스코)


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    238. Choi, E., Lee, E.K., Heo, H., Choi, J., Ha, Y.M., Kim, J., Han,Y., Kim, Chung, H.Y.: χ-irradiation induces apoptosis through NF-κB activation and ONOO- generation-mechanism of χ ?irradiation-induced apoptosis through ONOO generation. 2nd Asian Congress of Radiation Research 2009. Korean Assiociation for Radlation Research (2009.05.17~20 서울 벡스코)


    239. Lee, E.K., Heo, H.S., Choi, J., Kim, J.M., Ha, Y.M., Choi, E.K., Han, Y.K., Kim, H.J., Yu, B.P., Chung, H.Y.: Aging and χ-irradiation induce inflammatortory respponse throuh endogenous liipopolysaccharide. 제20차 한국노화학회 춘계학술대회. 한국노화학회, 아주대학교 의과대학 BK21 세포변형 및 재생연구사업단등(2009.05.14 아주대학교 병원 대강당)


    240. Kim, J.M., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Chung, H.Y.: Effect of angiotensin Ⅱ converting enzyme inhibitor and angiotensin Ⅱ receptor blocker on pro-inflammatory response in ageo rat. 제20차 한국노화학회 춘계학술대회. 한국노화학회, 아주대학교 의과대학 BK21 세포변형 및 재생연구사업단등(2009.05.14 아주대학교 병원 대강당)


    241. 정해영: 혈관노화의 분자기전. 제10차 대한노화방지의학회 추계학술대회. 대한노화방지의학회(2009.09.20 가톨릭의대 서울성모병원)


    242. Heo, H.S., Lee, E.K., Kim, J.M., Choi, J.H Choi, E.K., Han, Y.K., Kim, H.J., Chung, H.Y.: Aging Tissue Bank and Aging Related Databases. 1stANRRC&Asian Chapter Meeting of ISBER.(2009.09.22~25 COEX Convention Center Seoul, Korea)


    243. Heo H.S., Lee, E.K., Kim, J.M., Choi, J.H Choi, E.K., Han, Y.M., Kim, H.J., Chung, H.Y.: Aging Tissue Bank. 1stANRRC&Asian Chapter Meeting of ISBER.(2009.09.22~25 COEX Convention Center Seoul, Korea)


    244. Kim, J.M., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Kim, H.J., Han, Y.K., Uehara, Y.H.: Effect of ACEI and ARB on Pro-inflammatory Response in Aged Rats. PROCEEDING OF THE FALL INTERNATIONAL CONVENTION. 한국과학기술단체총연합회, 한국연구재단, 식품의약품안전청, 대한약사회, 한국제약협회.(2009.10.15~16, Seoul Hotel)


    245. Lee, E.K., Choi, J.H., Kim, J.M., Chung, H.Y.: Disruption of Intestinal Barrier via Mitochondroal Caspase-Dependent Apoptotic Signaling in Aged Rat. PROCEEDING OF THE FALL INTERNATIONAL CONVENTION. 한국과학기술단체총연합회, 한국연구재단, 식품의약품안전청, 대한약사회, 한국제약협회.(2009.10.15~16, Seoul Hotel)


    246. Kim, j.m., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Kim, H.J., Han, Y.K., Uehara, Y.H.,Chung, H.Y.: Anti-oxidant activity of morin(3,5,7,2’,4’-Pentahydroxyflavone) modulates RS-induced NF-Kb. Food for and longevity 2009 international Symposium and Annual Meeting. The Korean Society of Food Science and Nutriton.( 2009.11.04~06, Changwon)


    247. Bea, S.J., Kim, j.m., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Kim, H.J., Han, Y.K., Uehara, Y.H., Chung, H.Y.: 5-hydroxytryptophan inhibits t-BHP-induced oxidative damage via the suppression of RS and NF-Kb activation on human fivroblast. Food for and longevity 2009 international Symposium and Annual Meeting. The Korean Society of Food Science and Nutriton.( 2009.11.04~06, Changwon)


    248. Bea, S.J., Lee, S.J., Kim, j.m., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Kim, H.J., Han, Y.K., Chung, H.Y.: The anti-Apoptotic Action of 5-Hydroxyindole: Protection of Mitocondrial Integrity. Food for and longevity 2009 international Symposium and Annual Meeting. The Korean Society of Food Science and Nutriton.( 2009.11.04~06, Changwon)


    249. Bea, S.J., Kim, j.m., Lee, E.K., Heo, H.S., Choi, J.H., Ha, Y.M., Choi, E.K., Kim, H.J., Han, Y.K., Song, S.H., Lee, H.J., Suh, H.S., Chung, H.Y.: A Newly Synthesized Potent Tyrosinase Inhibitor : 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol. Food for and longevity 2009 international Symposium and Annual Meeting. The Korean Society of Food Science and Nutriton.( 2009.11.04~06, Changwon)


    250. Chung, H.Y.: Longevity by Modulation of Age-related Micro-inflammation. Food for and longevity 2009 international Symposium and Annual Meeting. The Korean Society of Food Science and Nutriton.( 2009.11.04~06, Changwon)


    251. Lee, E.K., Chung, H.Y.: Significance of protein tyrosine kinase/ protein tyrosine phosphatase blance on the regulation of NF-κB activation in the inflammatory process and aging. 2009 한국노화학회 추계학술대회. 한국노화학회. (2009.11.20, 서울시립대학교 자연과학관)


    252. Kim, J.M., Lee, E.K., Heo, H.S., Choi, J., Ha, Y.M., Choi, E., Kim, H.J., Han, Y.K., Uehara, Y., Chung, H.Y.: Anti-oxidant activity of morin (3,5,7,2’,4’,-pentahydroxyflavone) modulates ROS-induced NF-κB. 2009 한국노화학회 추계학술대회. 한국노화학회. (2009.11.20, 서울시립대학교 자연과학관)


    253. Chung, H.Y.: Modulation of Redox Signaling in Aging Process. 2009 한국 프리라디칼학회 학술대회. 한국프리라디칼학회. (2009.12.04, 한국원자력의학원 방사선비상진료 센터 1층 강당)


    254. Lee, E.K., Kim, J.M., Heo, H.S., Choi, J., Ha, Y.M., Choi, E., Kim, H.J., Han, Y.K., Uehara, Y., Chung, H.Y.: Role of Protein Tyrosine Kinase/Protein Tyrosine Phosphatase Blance in the Regulation of NF-κB Activation in the aging process. 2009 한국 프리라디칼학회 학술대회. 한국프리라디칼학회. (2009.12.04, 한국원자력의학원 방사선비상진료 센터 1층 강당)


    255. Bae, S.J., Lee, E.K., Kim, J.M., Heo,H.S., Choi, J., Ha, Y.M., Choi, E., Kim, H.J., Han, K.Y., Uehara, Y., Chung, H.Y.: 5-Hydroxytryptophan Modulates t-BHP-induced Oxidative damage via the Suppression of RS and NF-κB Activation on Human Fibroblast. 2009 한국 프리라디칼학회 학술대회. 한국프리라디칼학회. (2009.12.04, 한국원자력의학원 방사선비상진료 센터 1층 강당)


    256. Bae, S.J., Lee, E.K., Kim, J.M., Heo,H.S., Choi, J., Ha, Y.M., Choi, E., Kim, H.J., Han, K.Y., Uehara, Y., Chung, H.Y.: Anti-Apoptotic Action of 5-Hydroxyindole: Protection of Mitochondrial integrity. 2009 한국 프리라디칼학회 학술대회. 한국프리라디칼학회. (2009.12.04, 한국원자력의학원 방사선비상진료 센터 1층 강당)


    257. Bae, S.J., Lee, E.K., Kim, J.M., Heo,H.S., Choi, J., Ha, Y.M., Choi, E., Kim, H.J., Han, K.Y., Uehara, Y., Chung, H.Y.: Morin Modulates RS-induced NF-κB Signaling. 2009 한국 프리라디칼학회 학술대회. 한국프리라디칼학회. (2009.12.04, 한국원자력의학원 방사선비상진료 센터 1층 강당)


    258. Ha, Y.M., Han, Y.K., Lee E.K., Kim, J.M., Choi, J.H., Suh, H.S., Yu, B.P., Chung H.Y.: Newly Synthesized Resveratrel Analogs : Potent Sirt 1 Activators against UVA-induced Inflammation. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    259. Ha, Y.M., Song, S.H., Lee, H.J., Suh, H.S., Lee, E.K., Kim, J.M., Choi, J.H., Kim, H.J., Han, Y.K., Chung, H.Y.: 4-(6-Hydroxy-2-nathyl)-1,3-bezendiol: A Potent, New Tyrosinase Inhibitor. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    260. Han, Y.K., Lee, E.K., Kim, J.M., Choi, J.H., Ha, Y.M., Choi, Y.J., Kim,H.J., Uehara Y., Lee, J.W., Chung, K.W., Moon, H.R., Chung, H.Y.: MHY-A Suppresses Melanogenesis through Tyrosinase Infibition. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    261. Lee, E.K., Kim, J.M., Choi, J.H., Kim, H.J., Han, Y.K., Ha, Y.M., Chung, H.Y.: Baicalein Inhibits IR-induced Proinflammatory Responses through Regulation of NF-κB and FOXO Signaling Pathways. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    262. Kim, J.M., Lee, E.K., Choi, J.H., Park, M.H., Choi, Y.J., Han, Y.K., Kim, H.J., Jung, G.W., Lee, J.W., Ye, B.H., Uehara, Y., Ha, Y.M.: Exploration of Oxidative Stress-Induced Inflammatory Mechanism by Angiotensin Ⅱ in Aged Rat Kidney. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    263. Choi, Y.J., Lee, E.K., Kim, J.M., Choi, J.H., Ha, Y.M., Kim, H.J., Han, Y.K., Chung, H.Y.: Dietary Ferulate Modulates Renal FOXOL3a Activity via the PI3K/Akt Pathway during the Aging Process. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.04.15-16 대구 EXCO)


    264. Choi, J., Bae, S.J., Ha, Y.M., No, J.K., Lee, E.K., Lee, J.S., Song, S.H., Lee, H.J., Suh, H.S., Yu, B.P., Chung, H.Y.: A NEWLY SYNTHESIZED, POTENT TYROSINASE INHIBITOR: 5-(6-HYDROXY-2-NAPHTHYLY)-1, 2, 3-BENZENETRIOL. 2010 Spring Conference of the Korean Society for Gerontology and 10th Korea-Japan Gerontologist Joint Meeting. 한국노화학회(2010.06.30.- 07.02, KRIBB, DaeJeon, Korea)


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    269. Heo, H.S., Oh, S.J., Kim, J.M., Choi, Y.Z., Kim, H.J., Han, Y.K., Kim, H.S., and Chung, H.Y.: Database for Common Paterns and Combination of Transcriptional Regulatory Elements for Functional Classes of Mouse Trancripts .2010년도 한국분자?세포생물학회 정기학술대회. 한국분자?세포생물학회(2010.10.07~08, COEX , Seoul)


    270. Chung, K.W., Park, Y.J., Han, Y.K., Kim, H.J., Choi, Y.Z., Moon, H.R., Chung, H.Y.: A Newly Synthesized Strong Tyrosinase Inhibitor: MHY-C. 2010 PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.10.21-22, Ramada Plaza Cheongju Hotel)


    271. Kim, H.J., Lee, E.K., Han, Y.K., Kim. J.M., Choi, Y.J., Chung, H.Y.: Ferulic Acid Prevents Mitochondrial Dysfunction and Tght Junction Disruption by τ-BHP-Indurced Oxidative Stress in Caco-2 Cells. 2010 PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2010.10.21-22, Ramada Plaza Cheongju Hotel)


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    275. Lee, E.K., Kim, J.M., Choi, J., Kim, H.J., Han, Y.K., Ha, Y.M and Chung, H.Y.: Activation FOXOs by baicalein attenuates ionizing radiation-induced NF-?B inflammatory response in mice kidney. 방사선생명과학회 2010 춘계학술대회. 방사선생명과학회 (2010.05.07, 한양대학교 서울캠퍼스 동문회관)


    276. Ji Min Kim, Byeong Hyeok Ye, Eun Kyeong Lee, Yeon Ja Choi, Min Hee Park, Yu Kyeong Han, Hyun Jung Kim, Byung Pal Yu, Hae Young Chung: Mechanism of Ang Ⅱ Involvement in Activation of NF-?B through Phosphorylation of p65 in Aging. NAPA2011(International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer, 2011.02.16-19, Gyeongju Hilton Hotel, South Korea)


    277. Ji Min Kim, Yeon Ja Choi, Min Hee Park, Yohei Uehara, Ki Wung Chung, Byeong Hyeok Ye, Eun Ji Jang, Kyung Kyun Noh, So Ra Park and Hae Young Chung: Mechanism of Ang Ⅱ Involvement in Activation of NF-?B through Phosphorylation of p65 in Aging. KHUPO 11th Annual International Proteomics Conference (2011.03.31-04.01, Inje University)


    278. Daeui Park, Hyoung Oh Jeong, Hae Young Chung: Bioinformatics approaches to find potential therapeutic candidates using microarray and protein-protein interaction resources for psoriasis. KHUPO 11th Annual International Proteomics Conference (2011.03.31-04.01, Inje University)


    279. Ji Min Kim, Young Mi Ha, Yeon Ja Choi, Min Hi Park, Yohei Uehara, Byeong Hyeok Ye, Ki Wung Chung, Eun Ji Jang, Kyung Kyun Noh, So Ra Park and Hae Young Chung: ?/x-irradiation induces molecular inflammation. 2011년 방사선생명과학회 춘계학술대회. 방사선생명과학회. (2011.04.15-16, 부산대학교 본관 대회의실)


    280. Sang Woon Chung, Young Mi Ha, Ji Min Kim, Yeon Ja Choi, Min Hi Park, Yohei Uehara, Byeong Hyeok Ye, Ki Wung Chung, Eun Ji Jang, Kyung Kyun Noh, So Ra Park, Nam Deuk Kim and Young Chung: Molecular delineation of ?-ray-induced NF-?B activation and pro-inflammatory genes in SMP30 KO mice. 2011년 방사선생명과학회 춘계학술대회. 방사선생명과학회. (2011.04.15-16, 부산대학교 본관 대회의실)


    281. PARK Daeui, JEONG Hyoung Oh, CHUNG Hae Young: Bioinformatics Approaches to Find Potential Therapeutic Candidates Using Microarray and Protein-Protein Interaction Resources for Psoriasis. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2011.04.21-22 부산 BEXCO)


    282. HAN Yu Kyeong, LEE Eun Kyeong, CHOI Jehun, HA Young Mi, CHOI Yeon Ja, UEHRA Yohei, LEE Jeong Woo, CHUNG Ki Wung, MOON Hyung Ryong, CHUNG Hae Young : MHY-A Supresses Melanogenesis Through Tyrosinase Inhibition. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2011.04.21-22 부산 BEXCO)


    283. HA Young Mi: Design, Synthesis and Biological Evaluation of2-(substituted phenyl) thiaxolidine-4-carboxylic acid Dericatives as Novel Tyrosinase Inhibitors. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2011.04.21-22 부산 BEXCO)


    284. KIM Ji Min, CHOI Yeon Ja, PARK Min Hee, Ye Byeong Hyeok, CHUNG Ki Woong, UEHARA Yohei, CHUNG Hae Young: P4-35 Mechanism of Ang Ⅱ Involvement in Activation of NF-eB through Phosphorylation of p65 in Aging Process. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2011.04.21-22 부산 BEXCO)


    285. CHUNG Ki-Wung, PARK Yun-Jung, HAN Yu-Kyeong, HA Young-Mi, KIM Ji-Ming, CHOI Yeon-Js, CHUNG Hae-young, MOON Hyjung-Ryong: A Newly Synthesized Strong Tyrosinase Inhibitor: MHY-508. PROCEEDINGS of the Spring International Convention of The Pharmaceutical Society of Korea. 대한약학회. (2011.04.21-22 부산 BEXCO)


  • 특허(국내)

    번호

    발명자

      

    출원일

    출원번호

    등록일

    등록번호

    1

    김규원

    정해영

    이승기

    정원근

    글리시리진을 유효성분으로 하는 암세포 분화 유도제

    1995-11-16

    91766

    2

    김규원

    정해영

    손경희

    우르솔린산을 함유하는 혈관형성 억제제 조성물

    1996-03-25

    92-02116

    1996-07-02

    10481

    3

    김규원

    정해영

    손경희

    올레아놀산을 함유하는 혈관형성 억제제 조성물

    1996-03-25

    92-0211179

    4

    정해영

    최재수

    양영환

    김애라

    디하이드록시벤즈알데하이드 또는 이의 유도체를 유효성분으로 하는 미토콘드리아 보호제 및 항노화제

    2000-11-29

    01.09.28

    대한민국

    취득

    (2002)

    5

    최재수

    정해영

    정미정

    솔잎유래의 항산화물질 및 그 분리방법

    특허

    0429406

    02.02.15

    대한민국

    취득

    (2004)

    6

    최재수

    정해영

    정현아

    벚나무잎으로부터 분리한 항산화제 활성을 갖는 신규한 2-O-(6벤조일)-글루코피라노실 O-(Z) 쿠마릭 산을 포함한 천연화합물

    특허

    0413624

    03.12.18

    대한민국

    취득

    (2003)

    7

    정해영

    최재수

    김애라

    커피유래 3-메틸-1,2-사이클로펜탄당온을 유효성분으로 하는 효소 보호제 및 항노화제

    특허

    0484434

    05.04.12

    대한민국

    취득

    (2005)

    8

    정해영

    최재수

    티로시나제 저해제용 4,4`-

    디하이드록시바이페닐 화합물

     특허

    0502392

    05.07.19

    대한민국

    취득

    (2005)

    9

    최재수

    강혜숙

    손병화

    정지형

    정해영

    항산화 활성을 지닌 곰피 추출물로부터 분리한플로로탄닌류를 함유하는 조성물

      특허

    0512482

    05.08.29

    대한민국

    취득

    (2005)

    10

    최재수

    정해영

    김정은

    정현아

    항산화활성을 갖는 연수 추출물 및 그로부터 분리된 플라보노이드 화합물을 함유한 조성물

      특허

    0514916

    05.09.07

    대한민국

    취득

    (2005)

    11

    정해영

    추아니

    이지영

    혈중 세포접착분자를 이용하여 노화정도를 측정하는 방법

      특허

    0538318

    05.12.15

    대한민국

    취득

    (2005)

    12

    정해영

    박성준

    SAL-2를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물

      특허

    0594378

    06.06.21

    대한민국

    취득

    (2006)

    13

    정해영

    서홍석

    하영미

    노재경

    송수희

    이효진

    피부미백효과를 갖는 신규 옥시레스베라트를 유도체 및 이를 함유하는 조성물

      특허

    0760288

    07.09.13

    대한민국

    취득

    (2007)


  • 특허 (출원)

    번호

    발명자

    제목

    출원번호

    출원일자

    출원국

    출원/취득

    1

    정해영

    최재수

    양영환

    김애라

    디하이드록시벤즈알데하이드 또는 이의 유도체를 유효성분으로 하는 미토콘드리아 보호제 및 항노화제

    10-2000-0071708

    00.11.29

    대한민국

    출원

    2

    최원철

    정해영

    손병화

    규조류부터 분리한 자유라디칼 소거기능이 있는 화합물 및 그 제조방법

    2000-71702

    00.11.29

    대한민국

    출원

    3

    정해영

    최재수

    최혜리

    윤지성

    퍼옥시나이트라이트에 대한 소거 활성을 갖는 식물 추출물 및 이를 유효성분으로 하는 약학적 조성물

    10-2000-0072554

    00.12.01

    대한민국

    출원

    4

    최재수

    정해영

    김정은

    김병수

    울금유래의 항산화물질 그 분리방법

    2002-18319

    02.04.03

    대한민국

    출원

    5

    정해영

    최재수

    김애라

    연수유래 캄페롤 및 그 유도체를 유효성분으로 하는 효소 보호제 및 항노화제

    2002-30371

    02.05.30

    대한민국

    출원

    6.

    정해영

    최재수

    벚나무잎 유래 제니스테인 및 그 유도체인 제니스틴을 유효성분으로 하는 효소보호제 및 항노화제용 조성물

    2002-39412

    02.07.08

    대한민국

    출원

    7

    정해영

    김미경

    티로시나제 저해용 3,4-디하이드록 시만델릭산 화합물

     10-2002-0046121

    02.08.05

    대한민국

    출원

    8

    정해영

    최재수

    김형석

    이지영

    단삼유래 천연믈 디메틸리소스퍼메이트를 유효성분으로 하는 항산화제 및 항노화제

    2003-38823

    03.06.16

    대한민국

    출원

    9

    정해영

    최재수

    김대현

    황금 추출물 또는 이로부터 분리한 바이칼린, 바이칼레인, 우고닌 또는 5,7,2,5-테트라하이드록시-8,6-디메톡시플라본을 함유하는 노화방지 및 억제용 약학조성물

    10-2003-0037012

    03.06.10

    대한민국

    출원

    10

     정해영

    추아니

    이지영

    혈중 세포접착분자를 이용하여 노화정도를 측정하는 방법

    10-2003-0056559

    03.08.14

    대한민국

    출원

    11

    정해영

    최재수

    김지영

    감귤 유래 헤스페레틴을 유효성분으로 하는 항노화 조성물

    10-2004-006258

    04.08.09

    대한민국

    출원

    12

    정해영

    고은경

    베타인을 유효성분으로 하는 항산화, 항노화 또는 항염증용 조성물

    10-2004-0074450

    04.09.17

    대한민국

    출원

    13

    정해영

    박성준

    SAL-2를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물

    10-2004-0074449

    04.09.17

    대한민국

    출원

    14

    정해영

    고은경

    혈관염증 및 뇌염증을 억제할 수 있는 베타인 화합물을 이용한 약학조성물

    10-2005-0087276

    05.09.20

    대한민국

    출원

    17

    정해영

    서홍석

    하영미

    송수희

    강력한 SIRT1활성조절용으로써 UVA에 의한 피부염증 및 피부노화를 억제하는 레스베라트롤 유사체를 함유하는 조성물

    10-2009-0107285

    09.11.09

    대한민국

    출원

    18

    정지형

    당테흥

    유은숙

    강경진

    홍종기

    정해영

    김형식

    신규 카나비노이드 유도체 및 이의 의학적 용도

    10-2010-0008767

    10.01.29

    대한민국

    출원

    19

    정해영

    최재훈

    시나핀산을유효성분으로함유하는염증성질환예방 또는 치료용약학조성물

    10-2011-0005906

    11.01.20

    대한민국

    출원

    20

    정해영

    문형룡

    박민희

    하영미

    박윤정

    박지영

    김진아

    이지연

    이경진

    피부미백,항산화및PPAR활성을갖는신규화합물및이의의학적용도

    10-2011-0011543

    11.02.09

    대한민국

    출원

    21

    정해영

    박민희

    정기웅

    김진아

    박지영

    박윤정

    문형룡

    피부미백,항산화및PPAR활성을갖는신규화합물및이의의학적용도

    10-2011-0011545

    11.02.09

    대한민국

    출원

    22

    정해영

    박민희

    하영미

    한유경

    박지영

    박윤정

    김진아

    이지연

    송유민

    문형룡

    피부미백,항산화및PPAR활성을갖는신규화합물및이의의학적용도

    10-2011-0011544

    11.02.09

    대한민국

    출원


  • 저서

    발 표 연 도

          

    출 판 사

    총 페이지수

    비 고

    1998

    비주얼 생화학,분자생물학

    해돋이

    180

    역서

    1999

    산소의 두 얼굴

    해돋이 

    273

    역서

    2001

    생명현상의 분자기전

    월드

    사이언스

    269

    역서

    2001

    신분자 유전학

    신일상사

    270

    역서

    2001

    분자세포생물학, 분자의학

    월드

    사이언스

    303

    역서

    2002

    포스트게놈 시대의 생물정보학

    월드

    사이언스

    203

    역서

    2002

    인체의 지혜

    동명사

    317

    역서

    2004

    건강하게 오래 사는 비결

    신일상사

    79

    저서

    2005

    노인병학

    의학출판사

    1126(25)

    공저

    2005

    Exercise and disease

    Meyer & Meyer sport(UK)

    190(34)

    공저

    2005

    Oxidative Stress, Inflammation and Health

    Taylor & Francis

    636(33)

    공저

    2006

    건강과학

    신일상사

    175

    역서

     

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